HLA-DR2 and Dw2 in Narcolepsy and in Other Disorders of Excessive Somnolence Without Cataplexy

Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype

“…Our diagnostic criteria for EHS comprised three clinical items: (1) recurrent daytime sleep episodes that occur basically everyday over a period of at least 6 months; (2) absence of cataplexy; (3) the hypersomnia is not better explained by another sleep disorder, medical or neurological disorder, mental disorder, medication use or substance use disorder. [7][8][9][10] The diagnostic criteria for EHS correspond to narcolepsy without cataplexy and most of the idiopathic hypersomnia without long sleep time if we apply the criteria according to the International Classification of Sleep Disorders second edition (ICSD-2). Cataplexy is absent in both disorders.…”

“…About 30-50% of Japanese CNS hypersomnia patients other than narcolepsy with cataplexy carry the HLA-DRB1*1501-DQB1*0602 haplotype, whereas 12% of the general Japanese population carry the haplotype. [7][8][9] In this study, we examined the possible association between SNP rs1154155 in the TCRA locus and essential hypersomnia (EHS), CNS hypersomnia similar to narcolepsy with cataplexy, with regard to the symptom of excessive daytime sleepiness. [7][8][9][10] …”

An approach based on a genome-wide association study reveals candidate loci for narcolepsy

“…(2) absence of cataplexy; and (3) hypersomnia that cannot be explained by another sleep disorder, a medical or neurological disorder, a mental disorder, from medication use, or a substance abuse disorder (Honda et al 1986;Komada et al 2005;Miyagawa et al 2009Miyagawa et al , 2010. The diagnostic criteria for EHS correspond to narcolepsy without cataplexy and to most of the idiopathic hypersomnias without long sleep time, according to the International Classification of Sleep Disorders, second edition (ICSD-2).…”

Association of HLA-DR and –DQ Genes with Narcolepsy in Koreans

“…Strong association between narcolepsy and human leukocyte antigen (HLA) class II antigens, DR2 and DQ1, has been well documented in Japanese [2,3] and Caucasian populations [4 -7]. More recently, high resolution typing by DNA techniques has revealed that the DR2 and DQ1 serological specificities associated with narcolepsy correspond to the alleles DRB1*1501, *1503 (African-American) and DQB1*0602 [8 -10].…”