HLA-DRB1*1301 AND *1302 protect against chronic hepatitis B

Hawranek, Thomas; Gerken, Guido; Notghi, Arman; Lubjuhn, Roswitha; Taheri, Homa; Protzer, Ulrike; Löhr, H.F.; Schneider, P. M.; Büschenfelde, Karl-H. Meyer zum; Rittner, Christian

doi:10.1016/s0168-8278(97)80414-x

Cited by 152 publications

(126 citation statements)

References 23 publications

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“…8,15 A strong virusspecific CD4 ϩ and CD8 ϩ T-lymphocyte response to HBV has been associated with viral clearance, but comparatively little is known about the factors, which determine the individual' s ability to mount such a T-cell response. Recently, Thursz 6 and Hohler 7 conducted HLA genotyping of adults with persistent HBV infection who had demonstrated spontaneous recovery, and the relative frequency of DRB1*1301 and DRB1*1302 among HLA class II alleles was higher in SC. They concluded that a genetic factor was important in recovery from persistent HBV infection.…”

Section: Discussionmentioning

confidence: 99%

Association between hepatitis B virus infection and HLA-DR type in Korea

et al. 2000

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Hepatitis B virus (HBV) is a DNA virus, and its clinical course following initial infection is diverse. It varies from spontaneous recovery to chronic persistent infection that might progress to chronic hepatitis, cirrhosis, or result in the development of hepatocellular carcinoma. Various disease courses after HBV infection appear to be related to hepatocyte damage, caused not only by the HBV itself, but also by the host immune response.

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Section: Discussionmentioning

confidence: 99%

Association between hepatitis B virus infection and HLA-DR type in Korea

et al. 2000

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“…14,15 As with HCV infection, the host immune response to HBV infection determines viral persistence, 16,17 which has been associated with polymorphisms in the human leukocyte antigen complex and other immune response genes. [18][19][20][21][22][23][24] Although there are likely important differences in the mechanisms of HBV persistence, there is also evidence that NK T (NKT) cells play an important role. 25,26 The nonclassical MHC class I chain-related A (MICA) gene encodes a protein that functions as a ligand for NKG2D, an activating receptor on macrophages, CD8 þ T cells, gd T cells, NKT cells, and natural killer NK cells.…”

Section: Introductionmentioning

confidence: 99%

MICA and recovery from hepatitis C virus and hepatitis B virus infections

et al. 2004

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The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8 þ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA*015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval ¼ 0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA*015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA*015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.

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“…4 -6 Genetic association analyses based on Gambia, European, and Asian cohorts have implicated the human leukocyte antigen allele DRB1*1302 in the clearance of HBV infection. [7][8][9] Several population studies have also revealed that some non-human leukocyte antigen loci, including interferon ␥ (IFN-␥), 10 tumor necrosis factor ␣ (TNF-␣), 11 mannose binding protein (MBP), 12 and vitamin D receptor (VDR), 13 are associated with persistent HBV infection or HBV clearance. Disease susceptibility for infectious diseases is considered to be determined at different functional levels such as cytokine production, antigen presentation, and receptor recognition, as has been shown for malaria.…”

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confidence: 99%

Association of estrogen receptor α polymorphisms with susceptibility to chronic hepatitis B virus infection

Deng¹,

Zhou²,

Zhai³

et al. 2004

Hepatology

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Several studies have demonstrated that estrogen receptor ␣ (ESR1) participates in the pathogenesis of persistent hepatitis B virus (HBV) infection. To examine whether polymorphisms at the ESR1 gene locus are associated with persistent HBV infection, we resequenced ESR1 genomic region for single nucleotide polymorphisms (SNPs) in 27 unrelated Chinese. Two haplotypetagged SNPs (htSNP), T29C and A252966G, were selected for genotyping in 1,277 persistent HBV-infected cases, 748 spontaneously recovered controls, and 293 nuclear families using polymerase chain reaction (PCR)-restriction fragment length polymorphism (PCR-RFLP) analysis. We observed that the subjects bearing ESR1 29T/T genotype had an increased susceptibility to persistent HBV infection compared to those bearing at least one 29C allele (odds ratio 1.41; 95% CI, 1.17-1.71, P < .001). Consistent with the results of population-based association study, a significantly greater than expected transmission of the 29T allele (56.4%) from heterozygous parents to offspring with persistent HBV infection was observed ( 2 ‫؍‬ 4.60, P ‫؍‬ .033) using the transmission-disequilibrium test (TDT) in 293 nuclear families. Linkage disequilibrium (LD) mapping analysis indicated that the T29C polymorphism contained within a LD block located from promoter region to intron 3 of ESR1, suggesting that the strong association detected with T29C in ESR1 originated from ESR1 itself. In conclusion, our results suggest that the genetic variation at the ESR1 locus influences susceptibility to persistent HBV infection in a Chinese population. (HEPATOLOGY 2004;40:318 -326.)

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HLA-DRB11301 AND 1302 protect against chronic hepatitis B

Cited by 152 publications

References 23 publications

Association between hepatitis B virus infection and HLA-DR type in Korea

Association between hepatitis B virus infection and HLA-DR type in Korea

MICA and recovery from hepatitis C virus and hepatitis B virus infections

Association of estrogen receptor α polymorphisms with susceptibility to chronic hepatitis B virus infection

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