HLA-DRB1∗16 and -DQB1∗05 alleles are strongly associated with autoimmune pancreatitis in a cohort of hundred patients

Goni, Elisabetta; Ivonne, Regel; Mahajan, Ujjwal Mukund; Amodio, Antonio; Marchi, Gian Paolo; Beyer, Georg; Zuppardo, Raffaella Alessia; Leo, Milena Di; Lanzillotta, Marco; Bonatti, Francesco; Kauke, Teresa; Dick, Andrea; Weiß, Frank Ulrich; Schönermarck, Ulf; Lerch, Markus M.; Frulloni, Luca; Cavestro, Giulia Martina; Mayerle, Julia

doi:10.1016/j.pan.2022.03.015

Cited by 7 publications

(4 citation statements)

References 42 publications

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Section: Resultsmentioning

confidence: 99%

“…The amino acid motif corresponding to the 13 clonotypes generally featured only one variable position (position 8), whereas all other positions remained largely fixed ( Figure 6A ). It is also interesting to note that the presence of both HLA-DQB1*05 and HLA-DRB1*16 (which have high linkage disequilibrium) is associated with various autoimmune diseases 34,35 . This pattern of clonotypes was found in 75 donors and was almost always associated with positive COVID-19 status (63 out of 75 donors; Figure 6B ), allowing straightforward classification of a fraction of convalescent donors with a common HLA allele.…”

Section: Resultsmentioning

confidence: 99%

“…The amino acid motif corresponding to the found clonotypes has only one variable position (position 8), whereas all the other positions remain fixed (Figure 6C). It is also interesting to note that the presence of both HLA-DQB1*05 and HLA-DRB1*16 (which have high linkage disequilibrium) is associated with various autoimmune diseases 34,35 . While our previous attempts to incorporate HLA information in COVID-19 classifier didn't result in any gains in accuracy, we suggest that it might be due to limited cohort size and the presence of a large number of rare HLA alleles.…”

Section: Assessment Of Covid-19-associated Tcr Biomarkersmentioning

confidence: 99%

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Robust detection of SARS-CoV-2 exposure in the population using T-cell repertoire profiling

Vlasova,

Nekrasova,

Komkov

et al. 2023

Preprint

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The COVID-19 pandemic clearly demonstrates the need to monitor the spread of infectious diseases and population immunity. Probing adaptive immunity by sequencing the repertoire of antigen receptors (Rep-Seq) encoding specificity and immunological memory has become a method of choice for immunology studies. Rep-Seq can detect the imprint of past and ongoing infections and study individual responses to SARS-CoV-2 as shown in a number of recent studies. Here we apply a machine learning approach to two large datasets with more than 1200 high-quality repertoires from healthy and COVID-19-convalescent donor repertoires to infer T-cell receptor (TCR) repertoire features that were induced by SARS-CoV-2 exposure. Proper standardization of Rep-Seq batches, access to human leukocyte antigen (HLA) typing and both α- and β-chain sequences of TCRs allowed us to generate a high-quality biomarker database and build a robust and highly accurate classifier for COVID-19 exposure applicable to individual TCR repertoires obtained using different protocols, paving a way to Rep-Seq-based immune status assessment in large cohorts of donors.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Assessment Of Covid-19-associated Tcr Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

Robust detection of SARS-CoV-2 exposure in the population using T-cell repertoire profiling

Vlasova,

Nekrasova,

Komkov

et al. 2023

Preprint

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“…Goni et al. prospectively investigated HLA alleles in 100 AIPs from Italy and Germany and reported that, despite the different histopathological characteristics of type 1 and type 2 AIPs, both subtypes were associated with a higher frequency of HLA-DRB1*16 alleles and a significant enrichment of HLA-DQB1 pure congeners (especially the HLA-DQB1*05 allele) compared to healthy controls, hypothesising that type 1 and type 2 AIPs share the same genetic susceptibility and may rely on similar immunogenic mechanisms ( 66 ). The role of HLA in the pathogenesis of type 2 AIP and UC remains unclear because of the high degree of linkage disequilibrium between HLA genotypes.…”

Section: Possible Pathogenesis Of Type 2 Aip–ucmentioning

confidence: 99%

Type 2 autoimmune pancreatitis associated with ulcerative colitis

Nan,

Wang

2023

Front. Immunol.

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Ulcerative colitis (UC) is a chronic idiopathic inflammatory disease mainly affecting the rectum and colon and causing diarrhoea and mucopurulent stools. UC can present with extraintestinal manifestations in various organs and systems and can be associated with various comorbidities. Autoimmune pancreatitis (AIP) is a specific type of pancreatitis associated with autoimmune abnormalities and is divided into two clinical types: type 1 (lymphoplasmacytic sclerosing pancreatitis) and type 2 (idiopathic ductocentric pancreatitis). The current study shows an association between type 2 AIP and UC, which may be related to genetic susceptibility, inflammatory factors, and immune response. The most common manifestation of AIP in patients with type 2 AIP–UC is abdominal pain with elevated pancreatic enzymes, whereas the presentation of UC in type 2 AIP–UC is more severe, with an increased risk of UC-related surgery. This review focuses on diagnosis, prevalence, pathogenesis, impact, and treatment to better understand type 2 AIP–UC, explore the molecular mechanisms of this condition, and encourage further research into the management of type 2 AIP–UC.

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