HLA-DRB1454 and predictors of new-onset asthma in HIV-infected Thai children

Bunupuradah, Torsak; Hansudewechakul, Rawiwan; Kosalaraksa, Pope; Ngampiyaskul, Chaiwat; Kanjanavanit, Suparat; Wongsawat, Jurai; Luesomboon, Wicharn; Sophonphan, Jiratchaya; Puthanakit, Thanyawee; Ruxrungtham, Kiat; Shearer, William T.; Ananworanich, Jintanat

doi:10.1016/j.clim.2014.12.006

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Among 1201 HIV-infected adolescents living in the USA, of whom 87% were perinatally-infected and 85% were taking ART, asthma was a common comorbid condition with an incidence of 1.2/100 person-years [35**]. In a study of Thai children with perinatally-acquired HIV, early initiation of ART was associated with higher CD4, and the prevalence of asthma (27%) exceeded that of uninfected Thai children (18%) [36*]. Asthma tended to be more common among individuals with preserved immune function, and may be linked to immune reconstitution [36*,37–39].…”

Section: Spectrum Of Chronic Lung Diseasementioning

confidence: 99%

“…In a study of Thai children with perinatally-acquired HIV, early initiation of ART was associated with higher CD4, and the prevalence of asthma (27%) exceeded that of uninfected Thai children (18%) [36*]. Asthma tended to be more common among individuals with preserved immune function, and may be linked to immune reconstitution [36*,37–39]. However, the prevalence may have been overestimated in these studies, as diagnosis was based on self-report, diagnostic codes or prescription of asthma-related medications.…”

Section: Spectrum Of Chronic Lung Diseasementioning

confidence: 99%

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Bronchiectasis and other chronic lung diseases in adolescents living with HIV

Attia

Miller

Ferrand

2017

Current Opinion in Infectious Diseases

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Purpose of review The incidence of pulmonary infections has declined dramatically with improved access to antiretroviral therapy (ART) and co-trimoxazole prophylaxis, but chronic lung disease (CLD) is an increasingly recognized but poorly understood complication in adolescents with perinatally-acquired HIV. Recent findings There is a high prevalence of chronic respiratory symptoms, abnormal spirometry and chest radiographic abnormalities among HIV-infected adolescents in sub-Saharan Africa, where 90% of the world’s HIV-infected children live. The incidence of lymphocytic interstitial pneumonitis, the most common cause of CLD in the pre-ART era, has declined with increased ART access. Small airways disease, particularly constrictive obliterative bronchiolitis and bronchiectasis are emerging as leading causes of CLD among HIV-infected adolescents in low- and middle-income countries. Asthma may be more common in high-income settings. Likely risk factors for CLD include recurrent pulmonary infections, air pollution, HIV-related immune dysfunction and untreated HIV infection, particularly during critical stages of lung development. Summary Globally, the importance of HIV-associated CLD as a cause of morbidity and mortality is increasing, especially as survival has improved dramatically with ART and growing numbers of children living with HIV enter adolescence. Further research is urgently needed to elucidate the natural history and pathogenesis of CLD, and to determine optimal screening, diagnostic and treatment strategies.

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Section: Spectrum Of Chronic Lung Diseasementioning

confidence: 99%

Section: Spectrum Of Chronic Lung Diseasementioning

confidence: 99%

Bronchiectasis and other chronic lung diseases in adolescents living with HIV

Attia

Miller

Ferrand

2017

Current Opinion in Infectious Diseases

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“…This difference may be attributed to some genetic impact on the specific allergen sensitive asthma and to some degree to the genetic and race population differences [ 18 ]. Other study in Thia reported that HLA-DRB*1454 is a predictor of new asthma in HIV infected children [ 19 ]. In India [ 20 ] and USA [ 21 ], studies showed a significantly higher frequency of HLA-DRB1*03 in asthmatics than in controls while in our study we found HLA-DRB1*03 is a protective allele against asthma.…”

Section: Discussionmentioning

confidence: 99%

Effect of HLA on development of asthma

Mahdi

Al-Hadithi

Raouf

et al. 2018

Annals of Medicine and Surgery

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BackgroundAsthma is a disease characterized by a chronic inflammation of the airways caused by the interaction of genetic susceptibility with environmental factors. Inflammation and remodeling are critical components of asthma. It is shown that many genes are involved in the pathogenesis of asthma.Aim of studyTo identify/compare the association between HLA-DRB1 alleles and development of asthma in a sample of Iraqi Arab Muslims.Patients and methodsA case-control study (forty patients and forty healthy control) was carried out in Medical city Teaching Hospital, Baghdad-Iraq. The study participants were patients with asthma consulted the hospital from September - 2013 to January - 2015. HLA –DRB1genotyping was done using a panel of sequence-specific oligonucleotide probes (SSOP) using HLA-DRB1amplification and hybridization kits (SSO HLA type DRB1 plus and Mastermix for HLA type DRB1 Amp plus kits -Innogenetics-Belgium) using automated method by AutoLipa – 48Innogenetics-Belgum.ResultsThere was an increased frequency of HLADRB1*03:01:01 in control group compared with patients group (P = 0.009, Odds ratio = 0.1228, 95% CI: 0.0254–0.5930). Other allele like HLA-DRB1* 070101was significantly increased in asthmatic patients in compares with control group (P = 0.005, Odds ratio = 6.641, 95% CI: 1.7319–25.4657).ConclusionsHLA alleles have an effect on development asthma in patients with HLA-DRB1*070101 while HLADRB1* 030101 may have a protective effect in Iraqi Arab Muslims individuals against development of asthma.

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“…This difference may be attributed to some genetic impact on the specific allergen sensitive asthma and to some degree to the genetic and race population differences [18]. Other study in Thia reported that HLA-DRB*1454 is a predictor of new asthma in HIV infected children [19]. In India [20] and USA [21], studies showed a significantly higher frequency of HLA-DRB1*03 in asthmatics than in controls while in our study we found HLA-DRB1*03 is a protective allele against asthma.…”

Section: Discussionmentioning

confidence: 99%

Effect of HLA on development of asthma

et al. 2015

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Background: Asthma is a disease characterized by a chronic inflammation of the airways caused by the interaction of genetic susceptibility with environmental factors. Inflammation and remodeling are critical components of asthma. It is shown that many genes are involved in the pathogenesis of asthma. Aim of study: To identify/compare the association between HLA-DRB1 alleles and development of asthma in a sample of Iraqi Arab Muslims. Patients and methods: A case-control study (forty patients and forty healthy control) was carried out in Medical city Teaching Hospital, Baghdad-Iraq. The study participants were patients with asthma consulted the hospital from September -2013 to January -2015. HLA -DRB1genotyping was done using a panel of sequence-specific oligonucleotide probes (SSOP) using HLA-DRB1amplification and hybridization kits (SSO HLA type DRB1 plus and Mastermix for HLA type DRB1 Amp plus kits -Innogenetics-Belgium) using automated method by AutoLipa -48Innogenetics-Belgum. Results: There was an increased frequency of HLADRB1*03:01:01 in control group compared with patients group (P = 0.009, Odds ratio = 0.1228, 95% CI: 0.0254-0.5930). Other allele like HLA-DRB1* 070101was significantly increased in asthmatic patients in compares with control group (P = 0.005, Odds ratio = 6.641, 95% CI: 1.7319-25.4657). Conclusions: HLA alleles have an effect on development asthma in patients with HLA-DRB1*070101 while HLADRB1* 030101 may have a protective effect in Iraqi Arab Muslims individuals against development of asthma.

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HLA-DRB1454 and predictors of new-onset asthma in HIV-infected Thai children

Cited by 4 publications

References 8 publications

Bronchiectasis and other chronic lung diseases in adolescents living with HIV

Bronchiectasis and other chronic lung diseases in adolescents living with HIV

Effect of HLA on development of asthma

Effect of HLA on development of asthma

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