HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication

HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. Its expression is restricted to some tissues in normal conditions but increases strongly in pathological conditions. The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases. The relevance of studies on HLA-G expression lies in the well known inhibitory effect of this molecule on all cell types involved in innate and adaptive immunity, favoring escape from immune control. In this review, we summarize the features of HLA-G expression by type of infections (i.e, bacterial, viral, or parasitic) detailing the state of knowledge for each pathogenic agent. The polymorphism, the interference of viral proteins with HLA-G intracellular trafficking, and various cytokines have been described to modulate HLA-G expression during infections. We also discuss the cellular source of HLA-G, according to the type of infection and the potential role of HLA-G. New therapeutic approaches based on synthetic HLA-G-derived proteins or antibodies are emerging in mouse models of cancer or transplantation, and these new therapeutic tools may eventually prove useful for the treatment of infectious diseases.

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“…Indeed a polymorphism of the binding site for this miRNA (the 263del/ins SNP) has been associated with poor control of HIV infection [117]. …”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory Properties of HLA-G in Infectious Diseases

Amiot

Samson

2014

Journal of Immunology Research

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“…First described at the maternal-foetal interface [26] been extensively studied in a number of diseases and was shown to be associated with low HLAG mRNA expression levels [17] through its influence on mRNA stability and splicing patterns [18] [31]. Individuals homozygote for the 14-bp insertion had a lower risk of developing HAT in our study population as suggested by the fact that the 14-bp insertion/insertion genotype was significantly more frequent in both endemic controls (OR = 0.27; p = 0.012) and seropositive individuals suspected to harbour latent infections (OR = 0.26; p = 0.043).…”

Section: Discussionmentioning

confidence: 99%

HLA-G 3’UTR 14 bp Insertion Is Associated with a Decreased Risk of Developing Human African Trypanosomiasis in the Côte d’Ivoire Population

Ahouty¹,

Koffi²,

Courtin³

et al. 2019

OJGen

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Human African trypanosomiasis (HAT), or sleeping sickness, caused by Trypanosoma brucei gambiense, is associated with diverse clinical outcomes. Host's genetic factors involved in immunity are potential factors that can regulate infection. Genetic polymorphisms within HLA-G could influence the level of HLA-G expression and therefore play a critical role in infection outcomes. The goal of our study was to investigate the association of 14 bp Indel

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“…miR-148a has been shown to bind to the HLA-C 3′-UTR. Next to cancer, the miRNA-148a expression is associated with the control of HIV [67][68][69][70]. Furthermore, miRNA-181a is upregulated in Hepatitis B virus infected cells and has a binding site in the 3′-UTR of the HLA-A gene, which might be a target of miRNA-181a [71].…”

Section: Antigen Processing and Presentation Machinery And Mirnasmentioning

confidence: 99%

The Role of Immune Modulatory MicroRNAs in Tumors

Seliger¹,

Meinhardt²,

Falke³

2016

RNA Interference

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Tumors could evade the control of CD8 + T and/or NK cell-mediated surveillance by distinct immune escape strategies. These include the aberrant expression of HLA class I antigens, coinhibitory or costimulatory molecules, and components of the interferon (IFN) signal transduction pathway. In addition, alterations of the tumor microenvironment could interfere with a proper antitumoral immune response by downregulating or inhibiting the frequency and/or activity of immune effector cells and professional antigen presenting cells. Based on the identification as major mediators of the posttranscriptional silencing of gene expression, microRNAs (miRNAs) have been suggested to play a key role in many biological processes known to be involved in neoplastic transformation. Indeed, miRNA expression is frequently deregulated in many cancer types and could have tumor-suppressive as well as oncogenic potential. This review focused on the characterization of miRNAs, which are involved in the control of the immune surveillance or immune escape of tumors and their use as potential diagnostic and prognostic biomarkers as well as therapeutic targets. Moreover, miRNAs can have dual activities by affecting the neoplastic and immunogenic phenotype of tumors.

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HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication

Cited by 19 publications

References 89 publications

Immunomodulatory Properties of HLA-G in Infectious Diseases

Immunomodulatory Properties of HLA-G in Infectious Diseases

HLA-G 3’UTR 14 bp Insertion Is Associated with a Decreased Risk of Developing Human African Trypanosomiasis in the Côte d’Ivoire Population

The Role of Immune Modulatory MicroRNAs in Tumors

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HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication

Cited by 19 publications

References 89 publications

Immunomodulatory Properties of HLA-G in Infectious Diseases

Immunomodulatory Properties of HLA-G in Infectious Diseases

HLA-G 3’UTR 14 bp Insertion Is Associated with a Decreased Risk of Developing Human African Trypanosomiasis in the C&#244;te d’Ivoire Population

The Role of Immune Modulatory MicroRNAs in Tumors

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Product

Resources

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HLA-G 3’UTR 14 bp Insertion Is Associated with a Decreased Risk of Developing Human African Trypanosomiasis in the Côte d’Ivoire Population