HLA-G isoforms, HLA-C allotype and their expressions differ between early abortus and placenta in relation to spontaneous abortions

Bora, Mayuri; Singha, Sushmita; Madan, Taruna; Deka, Gitanjali; Hazarika, Sumita Gogoi; Baruah, Shashi

doi:10.1016/j.placenta.2024.02.009

Placenta

2024

DOI: 10.1016/j.placenta.2024.02.009

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HLA-G isoforms, HLA-C allotype and their expressions differ between early abortus and placenta in relation to spontaneous abortions

Mayuri Bora,

Sushmita Singha,

Taruna Madan

et al.

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2024

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Role of Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia

Yue,

Meng

2024

American J Rep Immunol

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Preeclampsia is one of the most severe obstetric complications, yet its pathogenesis remains unclear. Decidual natural killer (dNK) cells, the most abundant immune cells at the maternal‐fetal interface, are closely associated with preeclampsia due to abnormalities in their quantity, phenotype, and function. This review summarizes the molecular mechanisms by which dNK cells regulate extravillous trophoblast (EVT) invasion, promote uterine spiral artery remodeling, and maintain immune tolerance. Furthermore, it explores how disruptions in these mechanisms and changes in the decidual microenvironment alter dNK cell properties, driving the progression of preeclampsia. Understanding the mechanisms of dNK cells and identifying potential therapeutic targets may provide new insights for clinical intervention.

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Role of Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia

Yue,

Meng

2024

American J Rep Immunol

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Insights into Reproductive Immunology and Placental Pathology

Szukiewicz

2024

IJMS

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HLA-G isoforms, HLA-C allotype and their expressions differ between early abortus and placenta in relation to spontaneous abortions

Cited by 2 publications

References 62 publications

Role of Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia

Role of Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia

Insights into Reproductive Immunology and Placental Pathology

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