HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

Kaya, Zühre; Gönen, Sevim; Çalışkan, Burcu; Kemer, Zeynep; Ünal, Ayşe Betül; Değirmenci, Enes

doi:10.6002/ect.2016.0135

Cited by 5 publications

(11 citation statements)

References 18 publications

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“…Our study showed that about one‐third of the patients with sibling donors found 0/6 antigen‐mismatched or 0/8 allele‐mismatched donors. This availability was comparable to those reported in western cohorts and apparently lower than those in Middle‐Eastern cohorts, which consist of communities with larger families. Because family size is shrinking and we could expect to find fewer HLA‐matched donors with fewer sibling donor‐candidates, the chances of finding HLA‐matched donors among nonsibling family members should be examined more carefully.…”

Section: Discussionsupporting

confidence: 78%

Wide availability of HLA‐matched or a few loci‐mismatched donors in the graft‐vs‐host direction among nonsibling first‐degree relatives

Watanabe

Kanda

Kojima³

et al. 2020

HLA

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Although outcomes of hematopoietic stem cell transplantation from alternative donors have been improved, it has not yet challenged the precedence of HLA-matched or a few loci-mismatched donors. Because the availabilities of these donors among nonsibling relatives have been scarcely discussed, we analyzed them using a large Japanese dataset of HLA typing. Data set included HLA data from 2838 patients and their relatives, distributed in all parts of Japan. Antigen mismatches at the HLA-A, -B, -DR loci and allele mismatches at the HLA-A, -B, -C, -DRB1 loci were examined. The availabilities of 0 to 1/6 antigen-mismatched donors among one parent-candidate and one siblingcandidate were 24.3% and 33.9%, and those of 0 to 2/8 allele-mismatched donors were 18.6% and 32.1%, respectively. Additional HLA-C antigen mismatches (18.1% vs 0.0%) along with the possession of 1 to 3/8 allele mismatches (31.3% vs 3.0%) were more frequently observed in parent-candidates than in sibling-candidate. Most multiple allele-mismatched pairs had HLA-B allele mismatches. In conclusion, expanding donor searches to include nonsibling relatives could widen the availability of conventional relative donors with 0 to 1/6 antigen mismatches or 0 to 2/8 allele mismatch to 20% to 30%.High-resolution typing including HLA-C locus examination should be performed, because additional mismatches at HLA-C loci along with multiple allele mismatches were often observed, especially among nonsibling pairs. K E Y W O R D Sallele-mismatched donors, antigen-mismatched donors, HLA, relative donors

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Section: Discussionsupporting

confidence: 78%

Wide availability of HLA‐matched or a few loci‐mismatched donors in the graft‐vs‐host direction among nonsibling first‐degree relatives

Watanabe

Kanda

Kojima³

et al. 2020

HLA

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“…The A*02 was the most frequently identified allele, which is consistent with the findings of previous studies. 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 The A*24 allele was the second most frequently observed allele. This was finding was consistent with those of most previous studies, except those of the study conducted by Pala et al 7 in the Thracian population.…”

Section: Discussionmentioning

confidence: 97%

“…The allele and some haplotype frequencies of our study were similar to those of most previous studies conducted in our country. 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 A comparison of the 8-digit HLA data frequency could not be conducted due to the lack of previous studies reporting the same in our nation.…”

Section: Discussionmentioning

confidence: 97%

“…A literature review revealed that studies from our country 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 or involving the Turkish population 11 have described the distribution of HLA -A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes. Our study is the first detailed HLA data analysis report from Turkey regarding LR and HR HLA-DPB1 allele frequency, genotype frequency, HR (4- or 8-digit) 6 loci alleles frequency, and 2-6 loci A:B:C:DRB1:DQB1:DPB1 haplotype frequencies in healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

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HLA Alleles, Genotype and Haplotype Analyzes from Central Anatolia Region of Turkey

2023

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Background: Although human leukocyte antigen (HLA) data for the Turkish population has been reported, there are no statistics on the HLA-DPB1 locus, which has recently received significant attention, particularly in hematopoietic stem cell transplantation. In addition, there is no study that has reported the 2-6 loci HLA haplotype distribution, 8-digit HLA allele frequency, and genotype frequency in the Turkish population. Aims: To evaluate the low and high resolution (2-4-8 digits) HLA-A, -B, -C, -DRB1, -DQB1, -DPB1 allele data using the data of 6100 healthy individuals from the Central Anatolian region of Turkey. Study Design: Retrospective cross-sectional study. Methods: All tests were performed using molecular HLA techniques: low-resolution DNA-based sequence-specific oligonucleotides, low/high-resolution DNA-based sequence-specific primer, and high-resolution next generation sequencing. A total of 6100 healthy donors with a minimum of 3 loci (HLA-A, -B, -DRB1) were analyzed for their HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 data. Pypop and HLA-net GENE[RATE] were used to analyze the data. Results: Among the HLA class I alleles, the following were the most frequently observed alleles: for HLA-A, A*02, A*24, A*03 , and A*01 ; for HLA-B, B*35, B*51 , and B*44 ; and for HLA-C, C*07, C*04 , and C*12 . Among the HLA class II alleles, the following alelles were the most frequently observed: for HLA-DRB1, DRB1*11, DRB1*04 , and DRB1*13 ; for HLA-DQB1, DQB1*03, DQB1*05 , and DQB1*06 ; and for HLA- DPB1, DPB1*04, DPB1*02 , and DPB1*03 . The most common alleles among HLA-DPB1 in the 4-digit evaluation were DPB1*04:01, DPB1*02:01, and DPB1*04:02. Among the HLA classes I and II, the following were the most frequently observed 8-digit alleles in HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 were A*02:01:01:01, B*49:01:01:01, C*04:01:01:06, DRB1*07:01:01:01, DQB1*03:01:01:02 , and DPB1*02:01:02:05 , respectively. The most common 6 loci haplotype was A*02~B*35~C*04~DRB1*11~DQB1*03~DPB1*04 (2.71%). Conclusion: In this study, low and high resolution HLA-DPB1 allele frequency, 6 locus haplotype frequency and genotype frequency were reported for the first time in Turkish population. These new data can be used to map HLA in our country and may provide ideas for potential future studies.

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“…Siblings and offspring of subjects suffering from S are five and four times more likely to develop the disease, respectively [ 75 , 76 , 77 , 78 ]. Different HLA second class (HLA-DR) alleles have been detected to be S-related [ 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ]: HLA DRB1*15 in the Turkish population [ 90 ]; HLADRB1*11 in subjects with extra-pulmonary S [ 91 ]; HLA DRB1*0401 in patients suffering from OS involvement [ 92 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Sarcoid Uveitis: An Intriguing Challenger

Allegri¹,

Olivari²,

Rissotto

et al. 2022

Medicina

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The purpose of our work is to describe the actual knowledge concerning etiopathogenesis, clinical manifestations, diagnostic procedures, complications and therapy of ocular sarcoidosis (OS). The study is based on a recent literature review and on the experience of our tertiary referral center. Data were retrospectively analyzed from the electronic medical records of 235 patients (461 eyes) suffering from a biopsy-proven ocular sarcoidosis. Middle-aged females presenting bilateral ocular involvement are mainly affected; eye involvement at onset is present in one-third of subjects. Uveitis subtype presentation ranges widely among different studies: panuveitis and multiple chorioretinal granulomas, retinal segmental vasculitis, intermediate uveitis and vitreitis, anterior uveitis with granulomatous mutton-fat keratic precipitates, iris nodules, and synechiae are the main ocular features. The most important complications are cataract, glaucoma, cystoid macular edema (CME), and epiretinal membrane. Therapy is based on the disease localization and the severity of systemic or ocular involvement. Local, intravitreal, or systemic steroids are the mainstay of treatment; refractory or partially responsive disease has to be treated with conventional and biologic immunosuppressants. In conclusion, we summarize the current knowledge and assessment of ophthalmological inflammatory manifestations (mainly uveitis) of OS, which permit an early diagnostic assay and a prompt treatment.

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HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

Cited by 5 publications

References 18 publications

Wide availability of HLA‐matched or a few loci‐mismatched donors in the graft‐vs‐host direction among nonsibling first‐degree relatives

Wide availability of HLA‐matched or a few loci‐mismatched donors in the graft‐vs‐host direction among nonsibling first‐degree relatives

HLA Alleles, Genotype and Haplotype Analyzes from Central Anatolia Region of Turkey

Sarcoid Uveitis: An Intriguing Challenger

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