HLA haplotype diversity in the South Indian population and its relevance

Dedhia, Leenam; Gadekar, Shruti; Mehta, Pooja; Parekh, Sunil

doi:10.1016/j.ijt.2015.10.016

Cited by 21 publications

(16 citation statements)

References 23 publications

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“…Genomic DNA isolation was carried out by using a kit from Qiagen, and the first field resolution of HLA-A, -B and -DRB1 typing and genotype assignment were performed as described elsewhere [4]. The HLA genotype data of the comparator populations were obtained from the http://www.allelefrequencies.net database and the following publication on Kannada, Malayalam, Tamil, Telugu, Tulu [5], Indian Bengalis [6], Iranian Kurds [7], Nepalese [8], Pakistan Gujjar [9] and Lebanese [10].…”

Section: Methodsmentioning

confidence: 99%

HLA Profile of Kami Population Refutes the Earlier Proposition of Exclusive Closer Genetic Affinity of All the Gorkhas to Mongoloids

2020

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Objective: Based on the HLA profile of Indian Gorkhas, Debnath and Chaudhuri (2006) proposed that Gorkhas are genetically closer to Mongoloids, and they may have originated from Mongolians or Tibetan stocks. However, the major limitation of the earlier study was that Gorkhas comprise 2 broad groups, i.e. Tibeto-Burmans and Indo-Aryans. Besides, Gorkhas have an assemblage of many sociocultural and linguistically distinct populations such as Rai, Magar, Limbu, Tamang, Newar, Bahun, Kami, and so on. Thus, the generalization of the findings on Gorkhas by considering them as a single homogenous population may not be free from biases. Therefore, the present study aims to understand the genetic affinity of a constituent population from the Gorkha community, i.e. Kami, based on HLA polymorphism. Methods: First field HLA typing was performed among 158 Kami individuals by PCR-SSP methods. Results: The most frequent genes observed were HLA-A*11, HLA-B*15, HLA-DRB1*15. The frequency of HLA-DRB1*15 reported here is the highest recorded among the North Indian population to date, which is a noteworthy finding of the study. The hierarchical cluster analysis and principal component analysis showed that the Kami population lies within the cluster of the Indian subcontinental population. Conclusion: The study refutes the earlier proposition of exclusive belongingness of all the Gorkhas to Mongoloids.

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Section: Methodsmentioning

confidence: 99%

HLA Profile of Kami Population Refutes the Earlier Proposition of Exclusive Closer Genetic Affinity of All the Gorkhas to Mongoloids

2020

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“…[ 92 93 94 ] Birdshot chorioretinopathy has not been reported in any of the recent uveitis series from India,[ 95 96 97 98 99 ] which is not surprising because the HLA-A29 antigen is extremely rare or even nonexistent in the Indian populations of diverse ethnicity. [ 100 101 102 ]…”

Section: Non-infectious Uveitismentioning

confidence: 99%

Immunological tests and their interpretation in uveitis

Rathinam

Tuğal-Tutkun

Agarwal

et al. 2020

Indian J Ophthalmol

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Uveitis is a complex disorder including both infectious and non-infectious etiologies. Clinical diagnosis is a challenge because many diseases share common clinical signs. Laboratory support is crucial for confirming the clinical diagnosis. Laboratory diagnosis includes direct tests and indirect tests. For example smear, culture, and molecular diagnostics demonstrate the pathogens, hence they are direct tests. Immunologic tests employ an antigen to detect presence of antibodies to a pathogen, or an antibody to detect the presence of an antigen, of the pathogen in the specimens. The immunological tests used in laboratories are made by producing artificial antibodies that exactly “match” the pathogen in question. When these antibodies come into contact with a sample they bind to the matching pathogen if found in the sample. Hence they are grouped under indirect evidence. There are several investigations in uveitis to reach the confirmed diagnosis including microbiological, immunological, imaging and molecular diagnostic testing. In this section we will discuss immunological investigations of infectious and non-infectious uveitis.

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“…The top ranked haplotype are A*01:01:01 ~ B*57:01:01 ~ C*06:02:01 ~ DRB1*07:01:01 ~ DQB1*03:03:02 (h.f.: 0.020) and A*33:03:01 ~ B*44:03:02 ~ C*07:01:01 ~DRB1*07:01:01~ DQB1*02:02:01 (h.f.: 0.017). These haplotypes are common among South Indian populations …”

Section: Conflict Of Interestmentioning

confidence: 99%

“…These haplotypes are common among South Indian populations. 3 A*02:11:01~B*35:03:01~C*04:01:01~DRB1*15:02:02D QB1*06:01:01; A*24:02:01~B*27:07:01~C*15:02:01~D RB1*14:04:01~DQB1*05:03:01; and A*24:02:01~B*35:03: 01~C*12:03:01~DRB1*13:01:01~DQB1*06:03:01 are putatively unique haplotypes among Kannadigas, with copy numbers of 6, 4 and 3 respectively, and significant LD among twolocus consecutive haplotypes. However, this study needs to be further validated with larger sample size to confirm the existence of these putative population-specific haplotypes ( Figure 1C).…”

mentioning

confidence: 99%