HLA haplotypes in Koreans based on 107 families

Abstract

There are marked differences in the distribution of HLA haplotypes among different populations, and multilocus HLA haplotypes can best be studied by family analysis In the present study, 107 Korean families were analyzed for HLA-A, B, C, DR, and DQ antigens and haplotypes. Allele frequencies of more than 10% for class I antigens were A2. A24, A33, B44, B62, Cwl, Cw7, Cw9, CwlO, and C blank (CBL) and those for class II antigens were DR4, DR8, DR13, DR15. DQ1, DQ3, DQ4 and DQ7. In the analysis of HLA haplotypes, 18 kinds of A-B-DR and 11 kinds of A-C-B-DR-DQ haplotypes occurred at frequencies of more than 1%, comprising 34% and 24% of the total theoretical haplotypes, respectively. The five most common A-B DR haplotypes were exclusively related with the five most common A-C-B-DR-DQ haplotypes (frequency>2%). These remarkably conserved five-locus haplotypes in Koreans were A33-CBL-B44-DR13-DQl (5.4%), A24-Cw7-B7-

Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population

“…On the other hand, the protective effect of HLA-DRB1*13 against SARS found in our study might be rather weak and, for the time being, difficult to be supported by other studies, although this association itself is interesting because HLA-DRB1*13 has been reported to play a protective role in HBV infection [15,16] and malaria [17]. The possibly resistant allele, HLA-DRB1*13 is also one of the characteristic alleles in the Korean and Japanese population that did not experience SARS [18].…”

Reduced-intensity conditioning therapy with busulfan, fludarabine, and antithymocyte globulin for HLA-haploidentical hematopoietic cell transplantation in acute leukemia and myelodysplastic syndrome

“…It should be noted that the favorable outcomes of HLAhaploidentical HCT in our study were observed in Korean patients, an ethnic population with a low level of HLA-gene heterogeneity 30 and that experiences less GVHD after HLA-matched HCT. 31,32 Hence, further clinical studies are necessary to ascertain whether our results can be extended to patients of other countries.…”

Number of mutations within CTL‐defined epitopes of the hepatitis B Virus (HBV) core region is associated with HBV disease progression

“…These epitopes overlap with each other to form four specific regions within the HBV core protein (HBcAg), encompassing amino acid (aa) residues 11–27, 88–96, 107–125, and 139–151. The HLA haplo-types recognizing these epitopes are all found in the Korean population [Park et al, 1998]. To evaluate sequence changes, a consensus nucleotide sequence for all subject sequences was generated using Geneious Pro software (Biomatters), and sequences from individuals were then compared to this consensus sequence and nucleotide mutations were noted.…”