Hla Matching in Autoimmune Thrombocytopenic Purpura

HLA Antigens in Idiopathic Thrombocytopenic Purpura

“…The disagreement between our findings and that of Goebel et al [6,7] may be explained by sampling error, regional differences in HLA frequency prevalence or by different diag nostic criteria. In respect to the frequency of platelet antibodies as assessed by different techniques in the serum of patients with ITP, our percentage and that of Goebel et al are comparable (55 and 65, respective ly)-…”

“…An association of ITP with HLA-B8 and HLA-B12 was reported by Goebel et al [6,7], the first antigen being found in 70°/o, the latter in 45%> of 20 patients. The prevalence of both was reduced to about 7°/o in DTP.…”

“…An increased frequency of HLA-B8 has been reported in many autoimmune dis orders, e.g. myasthenia gravis [1], Graves' disease [1] and systemic lupus erythemato sus 14], Recently, Goebel et al [6,7] re ported a markedly increased frequency of HLA-B8 and B12 in patients with 1TP, but not in patients with DTP.…”

HLA Antigens, Blood Groups and Immunoglobulin Levels in Idiopathic Thrombocytopenic Purpura

“…Previous investigations have generally shown discrepancies or no significant correlation between HLA antigens and ITP [13][14][15][16][17][18]; however, Goebel et al [20] reported an association of ITP with HLA-B8 and HLA-B12, and Karpatkin et al [11] showed an in creased incidence of DR2 in association with an ele vation of haplotypes A26-BW38 and A3-B7 in ITP patients. The pattern of HLA antigens in the patients stud ied showed a significantly increased incidence (pc < 0.05) of HLA-A28, especially in chronic ITP pa tients.…”

“…It has been suggested that idiopathic thrombocytopenic purpura (ITP), is such a disease [6][7][8][9][10][11]. Previous investigations of the association of HLA antigens with ITP have shown discrepant results [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Immunoglobulin levels have been reported to be abnormal in ITP patients [21].…”