HLA polymorphism in type 1 diabetes Tunisians

Kamoun, Hassen; Hmida, Slama; Kâabi, H.; Abid, Abdelmajid; Houissa, Hichem; Maamar, M.; Mojaat, N.; Hamed, L. Ben; Dridi, A.; Zribi, M.; Nagati, K; Haddad, Anis; Boukef, K.

doi:10.1016/s0003-3995(02)01104-8

Cited by 22 publications

(26 citation statements)

References 17 publications

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“…All studies showed a positive association with DR3 and DR4, and a strong association of the heterozygote genotype DR4-DQw8/DR3-DQw2 to type 1 diabetes. [58][59][60] DR2 and DR5 were confirmed to play a protective role in this population group. 58 Similarly, Abid Kamoun et al have shown the DRB1*01501 DQB1*0602 and DRB1*11 DQB1*0301 haplotypes to be protective.…”

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confidence: 80%

“…58 Similarly, Abid Kamoun et al have shown the DRB1*01501 DQB1*0602 and DRB1*11 DQB1*0301 haplotypes to be protective. 60 The majority of studies that have focused on the HLA antigens (typed serologically) have been carried out in South Africa. In the first study, conducted in 1980, Briggs et al, found no increase in the frequency of B8 and B15, and no decrease in B7 in the 25 Xhosa type 1 diabetic patients.…”

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confidence: 99%

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The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

Padoa

2011

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Type 1 diabetes is a serious, debilitating disease, with life-threatening complications, and the financial burden associated with the management of this disease is enormous. Early diagnosis and intervention can improve morbidity and mortality. Unfortunately, in Africa, type 1 diabetes is poorly characterised, and there is sparse information regarding the aetiology and epidemiology of this disease. However, there is some evidence of a later age of onset in African type 1 diabetic patients, compared to European diabetics, and it is thought that the prevalence of type 1 diabetes is lower in African populations than in the Western world.

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confidence: 80%

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confidence: 99%

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

Padoa

2011

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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“…This association was described in several groups but not in Japanese people (Abid Kamoun et al, 2002;Chen et al, 1999;Caillat-Zucman, 2001;Parry and Brooks, 2008).…”

Section: Discussionmentioning

confidence: 96%

“…Furthermore, the high frequency of the heterozygous combination DRB1*03/DRB1*04 in patients (30.3%) indicates a synergistic effect on the risk to develop the disease. Indeed, reviews carried out during the last years revealed that 80 to 95% of the Caucasian insulin-dependent diabetics belong to the group DRB1*03 and/or DRB*04 against 40 to 50% from the control group (Abid Kamoun et al, 2002;Atkinson and Maclaren, 1994;Bouhours-Nouet and Coutant, 2005;Chen et al, 1999;Thomson, 2001). It is interesting to note that the DRB1*04 frequency observed in our study was significantly associated to type 1 diabetes (p < 0.0001) even though this allele was highly represented in the Moroccan healthy population.…”

Section: Discussionmentioning

confidence: 99%

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Human leukocyte antigen (HLA) polymorphism and type 1 diabetes in the Moroccan population

Benseffaj¹,

Brick²,

Atouf³

et al. 2012

Afr. J. Biotechnol.

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Insulin-dependent diabetes mellitus or type 1 diabetes is an autoimmune multifactorial disease which has a great socio-economic impact. In Morocco, less is known about the contribution of Human leukocyte antigen (HLA) alleles to type 1 diabetes susceptibility. Our study focused on evaluating the distribution of class II HLA genes among Moroccan patients presenting type 1 diabetes coming from different regions of the country. A total of 76 patients diagnosed with type I diabetes were compared to a group of 248 healthy controls matched by age, sex, and ethnic origin. The HLA class II (DR and DQ) typing of patients and controls was performed using polymerase chain reaction sequence-specific primers (PCR-SSP). Ambiguous typings were reanalyzed by Luminex technology. We found a significant association between HLA-DRB1*03 (p = 0.0001), DRB1*04 (p = 0.0001), DQB1*02 (p = 0.0001, OR = 4.4) and DQB1*03 (p = 0.002) alleles frequencies and the susceptibility to diabetes. The HLA-DQB1*06 allele was significantly decreased in patients (p = 0.008). DRB1*03-DQB1*02, DRB1*04-DQB1*03 and DRB1*04-DQB1*02 haplotypes induce susceptibility to type 1 diabetes while DRB1*13-DQB1*06 and DRB1*15-DQB1*06 haplotypes seems to confer a protective effect in our population. These data highlights that Moroccans diabetic patients do share a series of traits with diabetics of other origins but also have specific characteristics.

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HLA DR/DQ alleles and risk of type I diabetes in childhood: a population–based case–control study

et al. 2005

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The objective was to evaluate HLA DR/DQ alleles and their risk factor for type 1 diabetes in the Abruzzo region (central Italy). Sixty incident cases from the Abruzzo region were studied together with 120 unrelated control subjects living in the same administrative areas. The relative risk of diabetes associated with the alleles under study was calculated by deriving the odds ratio (OR) maximum likelihood estimates and their 95% confidence intervals (CI) by the exponentiation of the logistic regression beta-parameter. The combination DRB1*03/DQA1*0501/DQB1*0201 was found in 20.0% of patients and 7.1% of the control subjects, conferring an OR of 4.04 and a CI of 1.97-8.49. The combination DRB1*04/DQA1*0301/DQB1*0302 was found in 23.3% of diabetic patients and 6.7% of controls, giving an OR of 5.69 and a CI of 2.77-12.05. DRB1*11/DQA1*0505/DQB1*0301 and DQA1*0505/DQB1*0301 were negatively associated with type 1 diabetes (OR=0.27, CI 0.11-0.57; OR=0.07, CI 0.02-0.19). The DQA1 genotype at risk was found to be DQA1*0301/DQA1*0501: OR=23.80, CI 2.97-190.89, as it occurred with the highest frequency in the patient group. The DQB1 genotype at risk was found to be DQB1*0201/DQB1*0302, which occurred in 13.3% of patients but in only 1.1% of the control group (OR=29.75, CI 5.36-549.25). Our results shed further light on the risk of development of this disease during a specific time period in an area where the overall incidence of type 1 diabetes is known.

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HLA polymorphism in type 1 diabetes Tunisians

Cited by 22 publications

References 17 publications

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

Human leukocyte antigen (HLA) polymorphism and type 1 diabetes in the Moroccan population

HLA DR/DQ alleles and risk of type I diabetes in childhood: a population–based case–control study

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