HLA-Related Lymphocyte Responsiveness in Psoriasis

Gross, W L; Vorwerk, I.; Westphal, E.; Christophers, Enno; Hahn, Gabriele; Schlaak, M

doi:10.1159/000233314

Cited by 6 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In psoriasis, so far, only circumstantial evidence links streptococcal infections to HLA-Cw*0602 status, mainly in the guttate phenotype [ 4 - 8 ]. HLA genotypes are reported to influence T-cell proliferation in response to streptococcal antigens in vitro [ 9 , 10 ] and streptococci are known to modulate immune responses through molecular mimicry [ 11 ]. In vitro studies show homology between streptococcal M-proteins and human keratins, which may influence T-cell responses [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

HLA-Cw*0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control study

et al. 2009

View full text Add to dashboard Cite

BackgroundThe influence of streptococcal infections in the pathogenesis of psoriasis is not yet understood. In vitro data suggest that streptococcal factors influence T-cell function in psoriasis in a HLA-dependent manner, but studies designed to measure the HLA-C/Streptococci interaction are lacking. In the present study, we hypothesized that there is a statistical interaction between the result of streptococcal throat cultures and the presence of the HLA-Cw*0602 allele in psoriasis patients.MethodsWe performed a case control study using the "Stockholm Psoriasis Cohort" consisting of patients consecutively recruited within 12 months of disease onset (Plaque psoriasis = 439, Guttate psoriasis = 143), matched to healthy controls (n = 454) randomly chosen from the Swedish Population Registry. All individuals underwent physical examination including throat swabs and DNA isolation for HLA-Cw*0602 genotyping.The prevalence of positive streptococcal throat swabs and HLA-Cw*0602 was compared between patients and controls and expressed as odds ratios with 95% confidence intervals. Associations were evaluated separately for guttate and plaque psoriasis by Fisher's exact test.ResultsRegardless of disease phenotype, the prevalence of positive streptococcal throat swabs in HLA-Cw*0602 positive patients was twice the prevalence among HLA-Cw*0602 negative patients (OR = 5.8 C.I. = 3.57–9.67, p < 0.001), while no difference was observed among Cw*0602 positive versus negative controls.The corresponding odds ratios for the guttate and plaque psoriasis phenotypes were 3.5 (CI = 1.5–8.7, p = 0.01) and 2.3 (CI = 1.0–5.1, p = 0.02) respectively.ConclusionThese findings suggest that among HLA-Cw*0602 positive psoriasis patients, streptococci may contribute to the onset or exacerbation of the inflammatory process independent of the disease phenotype. However, studies on the functional interaction between HLA-C and streptococcal factors are needed.

show abstract

Section: Introductionmentioning

confidence: 99%

HLA-Cw*0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control study

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Whether these associations are circumstantial or do indeed contribute to pathophysiology remains to be established. In the late 1970s, Gross et al (1977Gross et al ( , 1983 reported that, in psoriasis, T-cell functions in response to in vitro exposure to streptococcal factors are influenced by HLA-C genotypes. No additional reports addressing this phenomenon are available since then.…”

Section: Introductionmentioning

confidence: 99%

HLA-C Expression Pattern Is Spatially Different between Psoriasis and Eczema Skin Lesions

Carlén

Sakuraba

Ståhle

et al. 2007

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Interactions between genetic and environmental factors underlie the immune dysregulation and keratinocyte abnormalities that characterize psoriasis. Among known psoriasis susceptibility loci (PSORS), PSORS1 on chromosome 6 has the strongest association to disease. Altered expression of some PSORS1 candidate genes has been reported but little is known about HLA-C expression in psoriasis. This study compared expression of major histocompatibility complex class Ia and HLA-C in psoriasis, allergic contact eczema, and normal skin. Although HLA-C was abundant in protein extracts from both eczema and psoriasis, a consistent and intriguing difference in the expression pattern was observed; strong immunoreactivity in the basal cell layer, polarized towards the basement membrane in psoriasis, whereas in eczema lesions HLA-C immunostaining was present mostly in suprabasal cells. Inflammatory cells in the dermis were strongly stained in both diseases. Normal skin epithelium showed less intense but similar HLA-C staining as eczema lesions. HLA class Ia expression overall resembled that of HLA-C in all samples. The distinct HLA-C expression patterns in psoriasis and eczema suggest a functional role in the specific psoriasis immune response and not only a general feature of inflammation.

show abstract

Zur Immunologie der Arthritis psoriatica

Schopf¹

1986

Arthritis Und Spondylitis Psoriatica

View full text Add to dashboard Cite

HLA-Related Lymphocyte Responsiveness in Psoriasis

Cited by 6 publications

References 6 publications

HLA-Cw*0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control study

HLA-Cw*0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control study

HLA-C Expression Pattern Is Spatially Different between Psoriasis and Eczema Skin Lesions

Zur Immunologie der Arthritis psoriatica

Contact Info

Product

Resources

About