HLA sharing and maternal HLA expression in couples with recurrent pregnancy loss in Taiwan

Hsiao, Tsun-Wen; Chung, Ming-Ting; Wen, Jen-Yu; Lin, Yilun; Lin, Liang-Yin; Tsai, Yung-Chieh

doi:10.1016/j.tjog.2021.11.039

Cited by 3 publications

(5 citation statements)

References 18 publications

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“…Insofar as the risk of RPL is dictated by female and male factors, a recent Taiwanese study described an association of select male HLA class II alleles with the altered risk of RPL. 50 A significantly higher frequency of DR4 (DRB1*04), DR12 (DRB1*12), and DR15 (DRB1*15) was demonstrated in infertile men with RPL than in fertile men. It was of interest to note that DR7 (DRB1*07) and DR10 (DRB1*10), which are found at low frequencies in women with RPL, 5,48 were also significantly lower in men with RPL.…”

Section: Discussionmentioning

confidence: 93%

“…It was of interest to note that DR7 (DRB1*07) and DR10 (DRB1*10), which are found at low frequencies in women with RPL, 5,48 were also significantly lower in men with RPL. 50 This prompts the speculation of an effector aspect of select HLA alleles in precipitating RPL, likely through preferentially selecting target antigenic fragments and presenting them to effector cells. 51 Consistent with our earlier finding on Lebanese women, no specific DQB1 alleles were found to be linked with RPL among Tunisian women.…”

Section: Discussionmentioning

confidence: 99%

“…A significantly higher frequency of DR4 ( DRB1*04 ), DR12 ( DRB1*12 ), and DR15 ( DRB1*15 ) was demonstrated in infertile men with RPL than in fertile men. It was of interest to note that DR7 (DRB1*07 ) and DR10 ( DRB1*10 ), which are found at low frequencies in women with RPL, 5,48 were also significantly lower in men with RPL 50 . This prompts the speculation of an effector aspect of select HLA alleles in precipitating RPL, likely through preferentially selecting target antigenic fragments and presenting them to effector cells 51 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Maternal HLA class II alleles and haplotypes associated with altered risk of recurrent pregnancy loss: A case‐control study

Aimagambetova,

Kapasheva,

Bahia

et al. 2024

American J Rep Immunol

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ProblemThis study analyzed the contribution of DRB1, DQB1, and DPB1 HLA class II alleles and resulting 3‐locus haplotypes to the overall risk of idiopathic recurrent pregnancy loss (RPL).Method of studyThe study participants included 188 Tunisian participants comprising 84 women with established diagnoses of RPL, and 104 matched multiparous females as controls. Genotyping of HLA alleles was done by PCR‐SSP.ResultsThe allelic frequencies of DPB1, DRB1, and DQB1 were consistent with Hardy‐Weinberg equilibrium among control subjects. Among class II alleles, DRB1*04:01:01 (p = .03), DRB1*08:01:01 (p = .04), and DPB1*01:01:01 (p = .04) were positively associated, whereas DPB1*04:01:01 (p = .012) and DPB1*14:01:01 (p = .006) were negatively associated with risk of RPL. The association of DRB1 and DPB1 alleles with RPL was lost after correction for multiple comparisons. The prevalence of the seven determined DQB1 alleles was not significantly different among case and control groups. Higher prevalence of DRB1*07:01:01∼ DQB1*02:01:01∼DPB1*04:01:01 (0.0417 vs. 0.000; p = .049) coupled with lower prevalence of DRB1*13:01:01∼DQB1*06:01:01∼DPB1*02:01:01 (0.0167 vs. 0.1000; p = .014) haplotypes was noted in women with RPL, thus could be considered as an RPL at‐risk and RPL‐protective haplotype, respectively.ConclusionThe study establishes weak/no contribution of class II alleles and corresponding 3‐locus haplotypes to the altered risk of RPL among Tunisian women and does not confirm previous findings on other Arab‐speaking populations of an HLA association with RPL.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal HLA class II alleles and haplotypes associated with altered risk of recurrent pregnancy loss: A case‐control study

Aimagambetova,

Kapasheva,

Bahia

et al. 2024

American J Rep Immunol

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“…Research on the involvement of HLA in RPL continues, with all types of HLA molecules being studied in this respect. Thus, numerous other HLA alleles have shown a significant association with RPL, such as the HLA-DRB1*07 allele [64] or the HLA-B13 allele, as well as the "shared HLA" phenomenon, referring to alleles shared by both partners, which, in turn, seem to increase the risk of RPL [92].…”

Section: Other Hla Molecules At the Maternal-fetal Interface And Thei...mentioning

confidence: 99%

Maternal–Fetal Compatibility in Recurrent Pregnancy Loss

Cuadrado-Torroglosa,

García-Velasco,

Alecsandru

2024

JCM

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Nowadays, recurrent pregnancy loss (RPL) is an undesirable condition suffered by many patients of reproductive age. In this scenario, certain immune cell populations and molecules, involved in maternal–fetal compatibility, have emerged as factors related with the pathogenesis of RPL. Among them, uterine Natural Killer cells (uNKs) appear to be of great relevance. These cells are involved in numerous processes during pregnancy, such as the remodeling of uterine spiral arteries or the control of trophoblast invasion. These functions are regulated by the interactions that these cells establish with the extravillous trophoblast, mainly through their Killer Immunoglobulin-like Receptors (KIRs) and the Human Leukocyte Antigen-C (HLA-C) molecules expressed by the embryo. A high level of polymorphism has been reported for both molecules involved in this interaction, with some of the possible KIR–HLA-C combinations being associated with an increased risk of RPL. However, the complexity of the maternal–fetal interface goes beyond this, as other HLA molecules also appear to be related to this reproductive pathology. In this review, we will discuss the role of uNKs in pregnancy, as well as the polymorphisms and clinical implications of KIR–HLA-C binding. We will also address the involvement of other, different HLA molecules in RPL, and the current advice on the appropriate management of patients with ‘immunological mismatch’, thus covering the main aspects regarding the involvement of maternal–fetal compatibility in RPL.

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HLA allele frequency of HLA-A, -B, -C, -DRB1 and -DQB1 in Indian recurrent implantation failure and recurrent pregnancy loss couples – A retrospective study

Shetty,

Santhosh,

S Pillai

et al. 2024

Journal of Reproductive Immunology

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HLA sharing and maternal HLA expression in couples with recurrent pregnancy loss in Taiwan

Cited by 3 publications

References 18 publications

Maternal HLA class II alleles and haplotypes associated with altered risk of recurrent pregnancy loss: A case‐control study

Maternal HLA class II alleles and haplotypes associated with altered risk of recurrent pregnancy loss: A case‐control study

Maternal–Fetal Compatibility in Recurrent Pregnancy Loss

HLA allele frequency of HLA-A, -B, -C, -DRB1 and -DQB1 in Indian recurrent implantation failure and recurrent pregnancy loss couples – A retrospective study

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