HLF/miR-132/TTK axis regulates cell proliferation, metastasis and radiosensitivity of glioma cells

Chen, Shu; Wang, Yang; Ni, Chunxia; Meng, Guang; Sheng, Xiaofang

doi:10.1016/j.biopha.2016.08.004

Cited by 50 publications

(44 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The optimal treatment for patients with glioma is surgical resection with chemotherapy, radiotherapy, or other adjuvant therapies. But the outcomes are typically poor, and the average survival of glioma patients is less than 18 months [1, 3, 20]. Studies on potential targets for molecular therapy of human glioma are critical.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

CMIP Promotes Proliferation and Metastasis in Human Glioma

Wang

2017

BioMed Research International

View full text Add to dashboard Cite

Glioma is one of the most common primary malignant brain tumors and the outcomes are generally poor. The intrinsic mechanisms involved in glioma development and progression remain unclear. Further studies are urgent and necessary. In this study, we have proven that CMIP (C-Maf-inducing protein) promotes cell proliferation and metastasis in A172 cells through knockdown of CMIP and in U251 cells through overexpression of CMIP by using MTT assay, cell colony formation assay, cell migration assay, and cell invasion assay. Furthermore, we discovered that CMIP upregulates MDM2, which is involved in the promoting role of CMIP in human glioma cells. For clinical study, 99 glioma tissues and 59 normal tissues were analyzed. CMIP expression was higher in glioma tissues than in normal tissues. In glioma tissues, CMIP is found to correlate positively with tumor grade but no significant correlation is found with patients' age, gender, or Karnofsky performance score (KPS). Moreover, CMIP also correlates with low relapse-free survival (RFS) rate and overall survival (OS) rate in glioma patients. Therefore, CMIP is oncogenic and could be a potential target for human glioma diagnosis and therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Glioma is one of the most common primary malignant brain tumors which occur in both children and adults [1, 2]. Conventional treatments for glioma including surgical resection, radiation, and chemotherapy have shown limited impact [3, 4].…”

Section: Introductionmentioning

confidence: 99%

CMIP Promotes Proliferation and Metastasis in Human Glioma

Wang

2017

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…MiR-132, which was first reported in the inflammatory context and is upregulated by pro-inflammatory signals [20] , has been reported to play important roles in tumorigenesis and progression in regulating cell proliferation, cell cycle, apoptosis, migration, invasion and angiogenesis [21][22][23][24][25] . MiR-132 is downregulated in several cancers, including breast cancer [21] , prostate cancer [26] , colorectal cancer [22] , osteosarcoma [27] , nonsmall cell lung cancer [24,28] , and hepatocellular carcinoma [29][30][31] .…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1

Wang

Ren²,

Ren

et al. 2017

Acta Pharmacol Sin

View full text Add to dashboard Cite

Dysregulation of microRNAs (miRNAs) has been implicated in cancer. Recently, miR-132 has been reported to be downregulated in the tissues of patients with breast cancer. In this study, we investigated the functional role of miR-132 and its direct target FOXA1 in breast cancer cells. In 30 human breast cancer tissues, FOXA1 was significantly overexpressed and negatively correlated with miR-132 expression. A bioinformatics analysis suggested that FOXA1 was a potential target of miR-132. Furthermore, dual luciferase reporter assays revealed that miR-132 dose-dependently inhibited the luciferase activity of the wt 3'UTR of FOXA1 rather than the mut 3'UTR of FOXA1 in human MDA-MB-468 and SK-BR3 breast cancer cells. Moreover, ectopic miR-132 expression significantly inhibited FOXA1 protein expression, whereas miR-132 knockdown promoted FOXA1 expression in the breast cancer cells. Ectopic miR-132 expression also suppressed proliferation of the breast cancer cells, whereas miR-132 knockdown promoted proliferation of the breast cancer cells, which was reversed by knockdown of FOXA1 expression. We conclude that MiR-132 suppresses proliferation of breast cancer cells at least partially though inhibition of FOXA1. These results suggest that miR-132 and FOXA1 may be potential biomarkers or therapeutic targets in breast cancer.

show abstract

“…[33] In additional, TTK is reported as a biomarker of cancer metastasis in various cancers. [34,35] Overexpression of KIF11 [36] or SPAG5 [37] can promote the tumor growth in TNBC, and associated with the worse prognosis. [38,39] RRM2 be considered as the early molecular markers for breast cancer [40] and be found that was higher expressed in tumoral metastasis and recurrence in colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification of Seven Hub Genes as the Novel Biomarkers in Triple-negative Breast Cancer and Breast Cancer Metastasis

Lian

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Breast cancer is one of the most common malignant tumors with the highest morbidity and mortality among women. Compared with the other breast cancer subtypes, Triple-negative breast cancer (TNBC) has a higher probability of recurrence and is prone to distant metastasis. To reveal the underlying disease mechanisms and identify more effective biomarkers for TNBC and breast cancer metastasis. Methods: Gene Ontology and KEGG pathway analysis were used for investigating the role of overlapping differentially expressed genes (DEGs). Hub genes among these DEGs were determined by the protein-protein interactions network analysis and CytoHubba. Oncomine databases were used for verifying the clinical relevance of hub genes. Furthermore, the differences in the expression of these genes in cancer and normal tissues were validated in the cellular, animal and human tissue.Results: Seven hub genes, including TTK, KIF11, SPAG5, RRM2, BUB1, CDCA8 and CDC25C, were identified that might be associated with TNBC and breast cancer metastasis. Meanwhile, these genes have been verified highly expressed in tumor cells and tumor tissues, and patients with higher expression of these genes have a poorer prognosis. Conclusions: Seven hub genes were potential biomarkers for the diagnosis and therapy of TNBC and breast cancer metastasis.

show abstract

HLF/miR-132/TTK axis regulates cell proliferation, metastasis and radiosensitivity of glioma cells

Cited by 50 publications

References 24 publications

CMIP Promotes Proliferation and Metastasis in Human Glioma

CMIP Promotes Proliferation and Metastasis in Human Glioma

MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1

Identification of Seven Hub Genes as the Novel Biomarkers in Triple-negative Breast Cancer and Breast Cancer Metastasis

Contact Info

Product

Resources

About