HLö-7 - A REVIEW OF ACETYLCHOLINESTERASE REACTIVATOR AGAINST ORGANOPHOSPHOROUS INTOXICATION

Abstract

SummaryThe treatment of organophosphate (OP) poisoning consists of the administration of a parasympatholytic agent, an anticonvulsant and an acetylcholinesterase (AChE) reactivator. Since there is no broad AChE reactivator available, a post-treatment strategy currently exploits administration of different types of oximes depending on the exposure of OP. In this contribution, we summarize all the available data about AChE reactivator HLö-7 including its synthesis, physico-chemical properties, pharmacokinetic and pharmacodynamics profile, and its efficacy in vitro and in vitro.

Organophosphorus compounds and oximes: a critical review

“…The HI-6 analog HLö 7, bearing two oxime functions in position 2 and 4 at one pyridinium ring, was considered to be a broad spectrum oxime with superior reactivating potency compared to HI-6 and good therapeutic efficacy against different nerve agents including tabun (Eyer et al 1992 ; Lundy et al 1992 ). A higher toxicity compared to HI-6, low stability in aqueous solutions and a challenging synthesis were the most likely reasons for the limited interest into HLö 7 in the recent years and the focus on HI-6 as the prime candidate oxime (Psotka et al 2017 ; Hsu et al 2019 ).…”