HMG-CoA Reductase Inhibitors and Coenzyme Q10

Nawarskas, James J.

doi:10.1097/01.crd.0000154790.42283.a1

Cited by 71 publications

(47 citation statements)

References 24 publications

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“…Neither supplementation of plant sterols or stanols nor supplementation with n-3 PUFA had any known clinical significant side effects, although n-3 PUFA supplementation (1) in the mevalonate pathway. The same pathway is shared by coenzyme Q 10 and as a consequence coenzyme Q 10 synthesis is inhibited (2) (112,113) . Coenzyme Q 10 supplements may raise the levels of coenzyme Q 10 (3) in plasma and platelets.…”

Section: Discussionmentioning

confidence: 99%

“…The only randomised controlled clinical trials investigating this area showed contrasting results and further well-performed clinical trials are needed to investigate whether CoQ 10 can be used to support statin therapy. Although several studies have shown that plasma CoQ 10 levels are decreased after statin therapy, existing evidence also suggests that skeletal muscle CoQ 10 levels are not affected or even increased after statins (113,115,116) .…”

Section: Effects Of Combination Therapy With Coenzyme Q 10 and Statinsmentioning

confidence: 99%

“…Besides being an intermediate in cholesterol synthesis, mevalonate is also a precursor of CoQ 10 ; statins thus lower CoQ 10 Table 8. Clinical studies towards the effects on lipid levels (total, LDL-and HDL-cholesterol and TAG) of the combination therapy with statins and n-3 PUFA: difference in effects of a statin plus n-3 levels (112,113) (Fig. 2).…”

Section: Mechanism Of Supporting Statin Therapymentioning

confidence: 99%

“…Although studies have repeatedly demonstrated reduced levels of plasma CoQ 10 with statin therapy (113,115 -117) and restored levels after oral CoQ 10 supplementation (113,118) , large randomised controlled trials towards the impact of CoQ 10 supplementation on statin-induced myalgia in patients with hyperlipidaemia are lacking. Only two double-blind controlled clinical trials investigating this area have been performed.…”

Section: Effects Of Combination Therapy With Coenzyme Q 10 and Statinsmentioning

confidence: 99%

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Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

et al. 2010

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Functional foods and dietary supplements might have a role in supporting drug therapy. These products may (1) have an additive effect to the effect that a drug has in reducing risk factors associated with certain conditions, (2) contribute to improve risk factors associated with the condition, other than the risk factor that the drug is dealing with, or (3) reduce drug-associated side effects, for example, by restoring depleted compounds or by reducing the necessary dose of the drug. Possible advantages compared with a multidrug therapy are lower drug costs, fewer side effects and increased adherence. In the present review we have focused on the support of statin therapy using functional foods or dietary supplements containing plant sterols and/or stanols, soluble dietary fibre, n-3 PUFA or coenzyme Q 10 . We conclude that there is substantial evidence that adding plant sterols and/or stanols to statin therapy further reduces total and LDL-cholesterol by roughly 6 and 10 %, respectively. Adding n-3 PUFA to statin therapy leads to a significant reduction in plasma TAG of at least 15 %. Data are insufficient and not conclusive to recommend the use of soluble fibre or coenzyme Q 10 in patients on statin therapy and more randomised controlled trials towards these combinations are warranted. Aside from the possible beneficial effects from functional foods or dietary supplements on drug therapy, it is important to examine possible (negative) effects from the combination in the long term, for example, in post-marketing surveillance studies. Moreover, it is important to monitor whether the functional foods and dietary supplements are taken in the recommended amounts to induce significant effects. Combination therapy: Dyslipidaemia: Statins: Functional foodsThe world market for functional foods (FF) and dietary supplements (DS) is expanding rapidly. In 2010 FF are expected to represent 5 % of the total global food market (1) and the market for DS is estimated at more than $60 billion worldwide (2) . In general, the target population of FF or DS is healthy individuals with slightly elevated risk factors or some physical discomfort. However, due to the fast growing market of FF or DS and the accompanying strong advertising and marketing, also patients on medication may be stimulated to use FF or DS. This may have several consequences for the quality of drug treatment as stated by de Jong et al. with the example of the combined intake of plant sterols and/or stanols and statins (3) . Whereas they addressed the additive effect of plant sterols and/or stanols on reducing LDL-cholesterol values in patients on statin treatment, their main focus was the possible negative aspects of the combination, such as unfavourable effects on patient adherence with drug treatment and increasing the potential for food-drug interactions.In the present review we will focus on the possible beneficial effects that FF or DS may have on drug therapy. Because of the large number of subjects treated suboptimally with statins (hydroxymethylglutaryl Co...

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Section: Discussionmentioning

confidence: 99%

Section: Effects Of Combination Therapy With Coenzyme Q 10 and Statinsmentioning

confidence: 99%

Section: Mechanism Of Supporting Statin Therapymentioning

confidence: 99%

Section: Effects Of Combination Therapy With Coenzyme Q 10 and Statinsmentioning

confidence: 99%

See 2 more Smart Citations

Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

et al. 2010

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“…The body content of CoQ10 decreased rapidly after the age of 40 years in humans with reduced biosynthesis (Kalen et al, 1989). The CoQ10 supplementation reversed the reduced circulating CoQ10 concentrations in statin-treated subjects as statin inhibits the pathways involved in both cholesterol and CoQ10 supplementation (Nawarskas, 2005;Fedacko et al, 2013). Various authors recommended daily intake of CoQ10 about 30-100 mg for healthy people over 40 years and 60-1200 mg for those undergoing an adjunctive therapy in some medical conditions (Jones et al, 2002, Bonakdar and Guarneri, 2005, Challem, 2005.…”

Section: Coenzyme Q10 Absorption Among Body Tissuesmentioning

confidence: 95%

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

Gopi¹,

Kumar²,

Elaiyaraja³

et al. 2015

Asian J. of Animal and Veterinary Advances

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The essentiality of nutrients keeps on changing with the advancement in nutritional research and genetic gain. The genetic gain especially in poultry sector is very high which results in increase in nutrient requirement of both the essential and non-essential nutrients. For the rapid growth the requirement of essential nutrients reaches many folds which are in direct relation with the performance, but the requirement for non-essential nutrients is an indirect one. Most of the dispensable amino acids, vitamin C, carnitine, etc. which are being synthesized endogenously are now a days unable to meet the birds requirements that warrants the dietary supply. Another important nutrient is coenzyme Q10 (CoQ10) which endogenously synthesized is now gaining much attention as a supplement for fast growing broilers. The CoQ10 can be termed as multi-functionary as each and every cell in the body needs this but quantity is being high for very active organs like heart, lungs, liver, kidney, etc. They are essential for cellular oxidative phosphorylation and regenerative antioxidant. The supplementation of CoQ10 improved the feed efficiency with reducing the electron leaks from mitochondria and increases total antioxidant capacity. For this property, CoQ10 is widely used in human medicine especially persons suffering from cardiac, neurological disorder, hypercholesterolemic condition and also even in cancer. The CoQ10 in poultry draws first attention when it is found to reducing the ascites mortality in marketable broilers. Thereafter, the advantages of CoQ10 is started to exploit with much attention to ascites, feed efficiency, cholesterol lowering effect nutraceutical and nutrigenomic property both in poultry and swine industry.

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Lipids, Atherogenic Dyslipidemia, and Therapy

Levine¹,

Levine²

2012

Metabolic Syndrome and Cardiovascular Disease

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HMG-CoA Reductase Inhibitors and Coenzyme Q10

Cited by 71 publications

References 24 publications

Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

Lipids, Atherogenic Dyslipidemia, and Therapy

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