HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases

Zheng, X.; Lu, Junmi; Liu, Jing; Zhou, Liufang; He, Yuefeng

doi:10.1016/j.biopha.2023.115118

Cited by 7 publications

(9 citation statements)

References 119 publications

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“…Gu et al. discovered that microRNA-218 inhibits glioblastoma cell proliferation by negatively regulating the HMGB1-RAGE axis ( 3 ) ( Figure 2 ).…”

Section: Hmgb1/rage Axis and Tumor Developmentmentioning

confidence: 99%

“…The HMGB family is the most abundant member of the high mobility group (HMG) superfamily of proteins ( 2 ). The proteins in this family are widely expressed and highly conserved in mammals throughout evolution ( 3 ). The family includes four members: HMGB1, HMGB2, HMGB3, and HMGB4 ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…Similar to HMGB1, HMGB2 contains two DNA-binding domains, box A and box B, as well as an acidic C-terminal tail composed of glutamic acid and aspartic acid residues. The main difference between HMGB1 and HMGB2 is that the C-terminal tail of HMGB1 consists of 30 amino acid residues, while HMGB2 has 22 amino acid residues in its C-terminal tail ( 3 ). Both HMGB1 and HMGB2 are regulated by post-translational modifications such as acetylation, phosphorylation, glycosylation, and methylation.…”

Section: Introductionmentioning

confidence: 99%

“…HMGB2 plays a similar role to HMGB1 in the development of cardiovascular diseases. In vascular pathologies, HMGB2 has autocrine and paracrine functions and can be released and bind to the membrane molecule RAGE, promoting intracellular signaling ( 3 ). Additionally, HMGB2 is involved in cellular aging processes ( 28 ) and promotes the proliferation of cervical cancer cells and melanoma cells through various mechanisms ( 29 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

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HMGB1/RAGE axis in tumor development: unraveling its significance

Fan,

Gao,

Tang

et al. 2024

Front. Oncol.

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High mobility group protein 1 (HMGB1) plays a complex role in tumor biology. When released into the extracellular space, it binds to the receptor for advanced glycation end products (RAGE) located on the cell membrane, playing an important role in tumor development by regulating a number of biological processes and signal pathways. In this review, we outline the multifaceted functions of the HMGB1/RAGE axis, which encompasses tumor cell proliferation, apoptosis, autophagy, metastasis, and angiogenesis. This axis is instrumental in tumor progression, promoting tumor cell proliferation, autophagy, metastasis, and angiogenesis while inhibiting apoptosis, through pivotal signaling pathways, including MAPK, NF-κB, PI3K/AKT, ERK, and STAT3. Notably, small molecules, such as miRNA-218, ethyl pyruvate (EP), and glycyrrhizin exhibit the ability to inhibit the HMGB1/RAGE axis, restraining tumor development. Therefore, a deeper understanding of the mechanisms of the HMGB1/RAGE axis in tumors is of great importance, and the development of inhibitors targeting this axis warrants further exploration.

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“…Gu et al. discovered that microRNA-218 inhibits glioblastoma cell proliferation by negatively regulating the HMGB1-RAGE axis ( 3 ) ( Figure 2 ).…”

Section: Hmgb1/rage Axis and Tumor Developmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HMGB1/RAGE axis in tumor development: unraveling its significance

Fan,

Gao,

Tang

et al. 2024

Front. Oncol.

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“…HMGB1 is a non-histone chromosomasal binding protein that exists in the nucleus of eukaryotic cells. Research has shown its involvement in the pathological processes of various diseases, including tumors (Tang et al 2023 ), chronic kidney disease (Liu et al 2023a , b ), autoimmune diseases (Ren et al 2023 ), and cardiovascular diseases (Zheng et al 2023 ). In the context of hematological malignancies, HMGB1 plays a pivotal role in modulating diverse biological processes, including cellular autophagy, differentiation, growth, immunity, and chemotherapy resistance (Yuan et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway

Zheng,

Wu,

Lin

et al. 2024

J Cancer Res Clin Oncol

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Purpose Acute myeloid leukemia (AML) is a refractory hematologic malignancy that poses a serious threat to human health. Exploring alternative therapeutic strategies capable of inducing alternative modes of cell death, such as ferroptosis, holds great promise as a viable and effective intervention. Methods We analyzed online database data and collected clinical samples to verify the expression and function of BMAL1 in AML. We conducted experiments on AML cell proliferation, cell cycle, ferroptosis, and chemotherapy resistance by overexpressing/knocking down BMAL1 and using assays such as MDA detection and BODIPY 581/591 C11 staining. We validated the transcriptional regulation of HMGB1 by BMAL1 through ChIP assay, luciferase assay, RNA level detection, and western blotting. Finally, we confirmed the results of our cell experiments at the animal level. Results BMAL1 up-regulation is an observed phenomenon in AML patients. Furthermore, there existed a strong correlation between elevated levels of BMAL1 expression and inferior prognosis in individuals with AML. We found that knocking down BMAL1 inhibited AML cell growth by blocking the cell cycle. Conversely, overexpressing BMAL1 promoted AML cell proliferation. Moreover, our research results revealed that BMAL1 inhibited ferroptosis in AML cells through BMAL1-HMGB1-GPX4 pathway. Finally, knocking down BMAL1 can enhance the efficacy of certain first-line cancer therapeutic drugs, including venetoclax, dasatinib, and sorafenib. Conclusion Our research results suggest that BMAL1 plays a crucial regulatory role in AML cell proliferation, drug resistance, and ferroptosis. BMAL1 could be a potential important therapeutic target for AML.

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Research progress on the protective effect of hormones and hormone drugs in myocardial ischemia-reperfusion injury

Wang,

Zhang,

et al. 2024

Biomedicine & Pharmacotherapy

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HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases

Cited by 7 publications

References 119 publications

HMGB1/RAGE axis in tumor development: unraveling its significance

HMGB1/RAGE axis in tumor development: unraveling its significance

Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway

Research progress on the protective effect of hormones and hormone drugs in myocardial ischemia-reperfusion injury

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