HMGB1: a potential target of controlling pulmonary inflammation in people living with HIV

Abstract

| http://medcraveonline.com remains an important public health problem that poses a serious threat to human health.AIDS combined with pulmonary infection is one of the most common diseases in opportunistic infections, accounting for 50%-69.6% of opportunistic infections. 2 The pathogenic microorganismincludes bacteria, fungi, Pneumocystis carinii, Mycobacterium, cytomegalovirus (CMV), etc.CD4+T lymphocytes of HIV-infected patients are progressively reduced or even disappeared, leading to cellular immune deficiency and increasing the probability of lung infection.Pulmonary opportunistic infections were rarely seen in patients with CD4+T lymphocytes >500/mm 3 .When CD4+T lymphocytes were >350/mm 3 , the clinical symptoms were similar to those of ordinary pulmonary tuberculosis patients.However, when CD4+T lymphocytes <200/ mm 3 , they were susceptible to Pneumocystis carinii, CMV, fungi, bacteria and mycobacterium atypia.There are many different kinds of lung infection, such as pneumocystis carinii pneumonia (PCP), CMV pneumonia, toxoplasma infection,tuberculosis, atypical mycobacteria disease and candida pneumonia etc. Among these infections, PCP and tuberculosisoccur more frequently, they often exist as one or more pathogenic microorganism. These infections develop fast, bring to clinical diagnosis and treatment of great difficulties, to become one of the leading causes of death among AIDS patients. 3,4 ©2020 Ding et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially.