HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia

Das, Nandini; Dewan, Varun; Grace, Peter M.; Gunn, Robin Jones; Tamura, Ryo; Tzarum, N.; Watkins, Linda R.; Wilson, Ian A.; Yin, Hang

doi:10.1016/j.celrep.2016.09.076

Cited by 125 publications

(89 citation statements)

References 59 publications

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“…An in vitro study demonstrated that pharmacological inhibition of TLR-4 or MyD88 also inhibited HMGB1-induced proinflammatory cytokine production [39]. Furthermore, it has been demonstrated that HMGB1 induces proinflammatory cytokine production in vivo via the TLR-4-MyD88-NF-κB pathway [40] (Fig. 2).…”

Section: Hmgb1 Signaling For the Initiation Of Different Diseasesmentioning

confidence: 92%

Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease

et al. 2018

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High mobility group box 1 protein (HMGB1), a sterile inflammatory molecule and damage-associated molecular pattern (DAMP) released from various cells during stress has been implicated in inflammation. Several reports show that there is a direct relationship between inflammation and cardiovascular diseases (CVDs) such as thrombosis, hypertension, insulin resistance, preeclampsia, etc. Here, we intend to summarize the concept of the emerging link between HMGB1 and CVDs. Furthermore, we will discuss the possible therapeutic strategies that target HMGB1 for the treatment of different CVDs.

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Section: Hmgb1 Signaling For the Initiation Of Different Diseasesmentioning

confidence: 92%

Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease

et al. 2018

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“…An in vitro study demonstrated that blocking TLR4 or MyD88 inhibited HMGB-1-induced proinflammatory cytokine production in mouse tracheal epithelial cells [58]. Furthermore, Das et al found that the interaction of HMGB-1 and TLR5 initiated NF-κB activation via MyD88, resulting in proinflammatory cytokine production in vivo [59]. These findings indicated that HMGB-1 exhibited its proinflammatory effect via the MyD88-dependent pathway by binding to its receptors.…”

Section: Figmentioning

confidence: 99%

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

Pei

et al. 2018

Cell Physiol Biochem

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High mobility group box-1 (HMGB-1), a typical damage-associated molecular pattern protein released from various cells, was first identified in 1973. It is usually stored in the nuclei of cells. Several modifications of HMGB-1 promote its translocation to the cytosol, and it is actively or passively released from cells. When outside of the cells, HMGB-1is crucial in inflammation. It exerts its biological functions via interaction with its receptors, including receptor for advanced glycation end products (RAGE) and Toll-like receptor 4(TLR4). A large number of studies showed a close link between inflammation and thrombosis. This review demonstrated the increased expression of HMGB-1 in thrombosis-related diseases, including coronary artery disease, stroke, peripheral arterial disease, disseminated intravascular coagulation, and venous thrombosis. Besides, it summarized the current understanding of the emerging link between HMGB-1 and thrombosis from three aspects: platelet, NETs, and coagulation and fibrinolysis factors. Finally, it explored the possible therapeutic strategies targeting HMGB-1 for treating thrombosis-related diseases.

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“…TLR5 is reported to express in a large range of cell types, and an agonist of TLR5 has various immunomodulatory influence on innate and adaptive immunity . High mobility group box‐1 protein (HMGB 1) can activate proinflammatory signaling through TLR5 and result in allodynia . It has been reported that TLR5 can open the door to the treatment of neuropathic pain .…”

Section: Introductionmentioning

confidence: 99%

“…13,14 High mobility group box-1 protein (HMGB 1) can activate proinflammatory signaling through TLR5 and result in allodynia. 24 It has been reported that TLR5 can open the door to the treatment of neuropathic pain. 25 Mechanical allodynia is inhibited in neuropathic pain by inhibiting TLR5mediated A-fiber.…”

mentioning

confidence: 99%

LncRNA X inactive specific transcript contributes to neuropathic pain development by sponging miR‐154‐5p via inducing toll‐like receptor 5 in CCI rat models

Wang

Zhang

et al. 2018

J of Cellular Biochemistry

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Noncoding RNAs, including long non‐coding RNAs (lncRNAs) and microRNAs, are involved in the development of neuropathic pain. Currently, we investigated that lncRNA X inactive–specific transcript (XIST) and toll‐like receptor 5 (TLR5) were greatly upregulated in chronic constriction injury rat models, whereas miR‐154‐5p (microRNA‐154‐5p) was significantly downregulated. Bioinformatics analysis was used to predict miR‐154‐5p as a target gene of XIST, and dual‐luciferase reporter tests proved the correlation between them. We observed that miR‐154‐5p was negatively modulated by XIST in vitro. XIST overexpression markedly induced neuropathic pain development in rats with chronic constriction injury, whereas the upregulation of miR‐154‐5p could reverse this phenomenon. Furthermore, TLR5 was demonstrated to be a target gene of miR‐154‐5p by using bioinformatics predictions. miR‐154‐5p negatively regulated TLR5 expression in vitro, and TLR5 was able to promote neuropathic pain development. In addition, overexpressing miR‐154‐5p can reverse the role of TLR5 neuropathic pain in vivo. Taken these together, we indicated that XIST could increase TLR5 expression by acting as a sponge of miR‐154‐5p in neuropathic pain development. This study revealed that XIST can contribute to neuropathic pain progression in rats through decreasing miR‐154‐5p and increasing TLR5. The XIST/miR‐154‐5p/ TLR5 axis can be provided as a novel therapeutic target in treating neuropathic pain.

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HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia

Cited by 125 publications

References 59 publications

Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease

Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

LncRNA X inactive specific transcript contributes to neuropathic pain development by sponging miR‐154‐5p via inducing toll‐like receptor 5 in CCI rat models

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