Hoarding Symptoms Are Not Exclusive to Hoarders

Novara, Caterina; Bottesi, Gioia; Dorz, Stella; Sanavio, Ezio

doi:10.3389/fpsyg.2016.01742

Cited by 14 publications

(9 citation statements)

References 30 publications

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“…Furthermore, the D2J strain showed a five-fold increase in the number of pellets retrieved per entry into the light (Fig.3C). This behavior is in some ways reminiscent of hoarding behavior exhibited by many patients with BE [6,50], including hoarding of food [51] with more severe hoarding behavior being associated with the presence of ED, in particular with females [52].…”

Section: Discussionmentioning

confidence: 99%

Genetic differences in the behavioral organization of binge eating, conditioned food reward, and compulsive-like eating in C57BL/6J and DBA/2J strains

Babbs

Kelliher

Scotellaro

et al. 2017

Preprint

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running head: Strain-dependent binge eating keywords (5-6): food seeking, GWAS, hoarding, QTL, sex differences, sucrose peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/190827 doi: bioRxiv preprint first posted online Sep. 19, 2017; 2 ABSTRACT Binge eating (BE) is a heritable symptom of eating disorders that carries significant health costs, including anxiety and depression, malnutrition, and sometimes obesity. The only FDA-approved drug for BE is an amphetamine-like stimulant; thus, the development of new therapeutics is critical for improving treatment outcome and minimizing side effects for patients. Genome-wide analysis of BE could lead to safer and more efficacious therapeutics. Here, we used our intermittent, limited access paradigm to examine strain differences in BE of palatable food, conditioned food reward, and compulsive-like eating between C57BL/6J (B6J) and DBA/2J (D2J) inbred mouse strains. We identified a robust strain difference in BE, with D2J showing escalation in consumption relative to B6J. Furthermore, D2J, but not B6J, showed a conditioned place preference for the food-paired side. D2J also showed compulsive-like eating in an anxietyprovoking environment, while simultaneously showing avoidance of the environment. Slope analysis of consumption in B6JxD2J F1-mice indicated different modes of inheritance for acute versus escalated food intake, suggesting different genetic factors underlying distinct components of BE. Heritability estimates of BE and compulsive-like eating were 56 and 73 percent, indicating that these traits are amenable to quantitative trait locus mapping. Finally, mice carrying one copy of a deletion in the first coding exon of Hnrnph1, a gene important for methamphetamine sensitivity, showed increased food consumption that was driven primarily by females. To summarize, we established a genetic model of BE and concomitant behaviors that will be useful in a systems genetics approach to understand BE. peer-reviewed)

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Section: Discussionmentioning

confidence: 99%

Genetic differences in the behavioral organization of binge eating, conditioned food reward, and compulsive-like eating in C57BL/6J and DBA/2J strains

Babbs

Kelliher

Scotellaro

et al. 2017

Preprint

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“…Although diagnoses are not made on the basis of a self-report questionnaire, an empirically established clinical cutoff serves as a guide for determining whether the severity of symptoms represents a clinically significant level of psychopathology. A clinical cutoff score of 41 for the Total score of the SI-R has been used to distinguish between hoarding and non-hoarding populations for both research (Novara, Bottesi, Dorz, & Sanavio, 2016) and clinical purposes (Steketee & Frost, 2014). The rationale underlying this cutoff score is a brief mention in a paper on another topic (Tolin, Meunier, Frost, & Steketee, 2011) that references an unpublished receiver operating characteristic (ROC) analysis distinguishing 74 hoarding participants from 58 community controls on the basis of SI-R scores.…”

Section: Limitationsmentioning

confidence: 99%

Saving inventory – Revised: Psychometric performance across the lifespan

Kellman-McFarlane

Stewart

Woody

et al. 2019

Journal of Affective Disorders

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Background: The Saving Inventory-Revised (SI-R) is the most widely used self-report measure of hoarding symptom severity. The goal of this study is to establish a firm empirical basis for a cutoff score on the SIR and to examine the functioning of the SIR as a screening tool and indicator of hoarding symptom severity across the lifespan. Methods: This study used archival data from 1,116 participants diagnosed with a clinical interview in 14 studies conducted by research groups who focus on hoarding. We used receiver operating characteristic (ROC) analysis and the Youden's Jstatistic to determine optimal cutoff scores for classifying participants who would be likely to receive a hoarding diagnosis. Results: Overall, the discriminant performance of the SIR Total score and each of the three subscales was high, confirming the status of the SIR is an excellent screening tool for differentiating hoarding from non-hoarding cases. The optimal SIR Total cutoff score is 39, although analyses suggested that older adults require a significantly lower cutoff and adults younger than 40 years require a significantly higher cutoff score. Limitations: The confidence interval around the optimal cutoff for the SIR Total score for oldest age group was wide in comparison to those reported for the younger groups, creating more uncertainty around the optimal cutoff score for this group. Conclusions: This paper provides investigators and clinicians with the data necessary to select evidence-based cutoff scores on the SIR that optimally suit their relative need for sensitivity and specificity in different age groups.

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“…In a study carried out in a sample of 400 chronic patients with schizophrenia, the authors reported that the percentage of patients manifesting abnormal acquisition behaviour was below 20% 2 . In a more recent study, 5.9% of patients diagnosed with psychotic disorders exceeded the cut-off for the diagnosis of HD 3 .…”

Section: Dear Editormentioning

confidence: 87%