Hodgkin disease in children: Clinicoepidemiologic and viral (Epstein‐Barr virus) analyses

Çavdar, Ayhan O.; Pamir, Ali; Gözdaşoĝlu, Sevgi; Babacan, Emel; Yavuz, G.; Ünal, Emel; Uluoglu, Ö.; Taçyıldız, Nurdan; İkincio??ulları, A.

doi:10.1002/(sici)1096-911x(199901)32:1<18::aid-mpo5>3.3.co;2-j

Cited by 4 publications

(5 citation statements)

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“…The Type 3 pattern, noted in HICs, is characterised by mainly nodular sclerosing subtype and less marked male predominance . South African children with HL appear to fall into a Type 2 pattern, as found in a “developing” country based on the marked male predominance, equal proportions of mixed cellularity and nodular sclerosing subtypes and majority presentation in the first decade of life. It is possible that varying upper age limits for admission to South African POUs may have skewed the data towards the younger age groups.…”

Section: Discussionmentioning

confidence: 95%

“…It is possible that varying upper age limits for admission to South African POUs may have skewed the data towards the younger age groups. Previous reports have demonstrated the striking relationship between socio‐economic and environmental factors and affected age groups, stating that an increased proportion of younger children with HL is found in countries with poor socio‐economic conditions.…”

Section: Discussionmentioning

confidence: 95%

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Treatment outcomes of children with Hodgkin lymphoma between 2000 and 2010: First report by the South African Children's Cancer Study Group

Geel

Chirwa

Rowe

et al. 2017

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Treatment outcomes of children with Hodgkin lymphoma between 2000 and 2010: First report by the South African Children's Cancer Study Group

Geel

Chirwa

Rowe

et al. 2017

Pediatric Blood & Cancer

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“…Moreover, Tsai and colleagues 25 have determined a relationship between IL-13 and the EBV ZTA protein in both cell lines as well as EBV infected lymphoblastoid cell lines and suggested a contribution of the increased expression of IL-13 in HL's pathogenesis. Formerly, we had determined a previous EBV infection rate of approximately 90% in patients with HL and BL treated in our center 26,27 .…”

Section: Resultsmentioning

confidence: 99%

Serum IL-13 levels at diagnosis and remission in children with malignant lymphoma

et al. 2016

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Interleukin (IL)-13 has been reported to have a role in the pathogenesis of lymphoma through recent molecular studies predominantly in adult patients. As malignant lymphomas in children differ from adult counterparts in terms of histology and response to treatment, we aimed to determine the serum IL-13 levels of patients with lymphoma; its relation with clinical-laboratory parameters and to look for any correlation of serum IL-13 levels with different prognostic factors in children. Twenty-eight patients with malignant lymphoma and 20 age-matched healthy controls were included in the study. The median serum IL-13 level at diagnosis (range 0.59-68 pg/ml, median 3.40 pg/ml) was higher than that in remission (range 0.14-12.2 pg/ml, median 1.60 pg/ml) in the HL group (p<0.05). Remarkably, median serum IL-13 level of patients with nodular sclerosis at diagnosis was higher than those with mixed-cellularity (p<0.05) and declined to normal limits during remission (p<0.05). In Burkitt's lymphoma (BL) subgroup, the median (range 2.94-154 pg/ml, median 4.5 pg/ml) was high and declined to normal levels during remission (range 0.55-11.30 pg/ml, median 1.57 pg/ml) and the difference was significant (p<0.05). In terms of prognostic factors, serum IL-13 levels were found to be associated with white blood cells counts only in HL group. Although the number of patients is limited in our study, we found that the serum IL-13 levels exhibit variances in different histopathologic groups. IL-13 might have a role in histopathogenesis of lymphoma, but seems to have no prognostic significance. Nevertheless, more molecular studies are needed to evaluate the pathogenesis of HL.

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“…17 In contrast, in Turkey and in some countries from Africa and Asia a very high EBV association has been found, with the percentage approaching 100%. [18][19][20] Cavdar et al 18 In our patients, serum EBV copies were elevated in 59% of HL cases at initial diagnosis and decreased significantly following induction chemotherapies and in the follow-up as shown in Fig. 1 (a, b).…”

Section: Discussionmentioning

confidence: 65%

Circulating Epstein-Barr virus DNA and cell-free DNA in pediatric lymphomas

Yalçın

Kutluk²,

et al. 2020

Turk J Pediatr

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Tumor-derived DNA is elevated in the serum of patients with cancer. The quantification of circulating Epstein Barr virus (EBV) DNA is reported to have an important role in the diagnosis and management of EBV-associated lymphoid malignancies. [1][2][3][4][5][6] Circulating cellfree total DNA (cf-DNA) has been studied in a wide range of physiological and pathological conditions, including pregnancy, trauma, inflammatory disorders and malignancies. 7,8 Elevated levels of cf-DNA have been reported in many tumour types including pediatric cancers. [8][9][10][11] Both serum EBV DNA and/or cf-DNA may become valuable sources for prognosis evaluation in pediatric lymphomas

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Hodgkin disease in children: Clinicoepidemiologic and viral (Epstein‐Barr virus) analyses

Cited by 4 publications

References 0 publications

Treatment outcomes of children with Hodgkin lymphoma between 2000 and 2010: First report by the South African Children's Cancer Study Group

Treatment outcomes of children with Hodgkin lymphoma between 2000 and 2010: First report by the South African Children's Cancer Study Group

Serum IL-13 levels at diagnosis and remission in children with malignant lymphoma

Circulating Epstein-Barr virus DNA and cell-free DNA in pediatric lymphomas

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