Hodgkin Lymphoma, Multiple Myeloma, Soft Tissue Sarcomas, Insect Repellents, and Phenoxyherbicides

Pahwa, Punam; McDuffie, Helen H.; Dosman, James A.; McLaughlin, John; Spinelli, John J.; Robson, Dave; Fincham, Shirley

doi:10.1097/01.jom.0000183539.20100.06

Cited by 23 publications

(24 citation statements)

References 73 publications

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“…27 No additional risk of developing STS, MM, and HL were observed from this combination of exposures (DEET, mecoprop, and the use of rubber gloves). 23 The combinations of exposure to pesticide ≥10 hours per year and positive family history of cancer increased the risk of NHL and MM. 22 In a recent publication of STS and pesticides exposure reported that insecticides aldrin and diazinon were significantly associated with increased risk of STS.…”

Section: Discussionmentioning

confidence: 99%

“…The study also had limitations common in casecontrol studies, which have been discussed in other publications. [22][23][24] This study had potential for recall bias and for misclassification of pesticides exposure and duration of exposure. This study did not have large enough numbers to evaluate dose-response relationships between specific pesticides and HL.…”

Section: Discussionmentioning

confidence: 99%

“…20 Association between pesticide exposure and other lymphohematopoietic malignancies examined in the overall study NHL, STS, and MM were discussed in previous articles. [22][23][24]27 The NHL was associated with individual pesticides mecoprop and aldrin, and major chemical classes with mixtures containing dicamba. 24 Exposure to insect repellents containing DEET (N, N-diethyl-m-toluamide), mecoprop, and the use of rubber gloves significantly increased risk of NHL compared to no exposure to above combination among farm residents/workers.…”

Section: Discussionmentioning

confidence: 99%

“…[22][23][24] These include the large number of cases and controls from residents of six Canadian provinces and an extensive list of potential occupational exposures and pesticides exposures at work and home. A major weakness in this study is the inability to ascertain exposure to the Epstein-Barr virus.…”

Section: Discussionmentioning

confidence: 99%

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Hodgkin Lymphoma and Pesticides Exposure in Men: A Canadian Case-Control Study

Karunanayake

Spinelli

McLaughlin

et al. 2012

Journal of Agromedicine

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The objective of this study was to investigate the putative associations of specific pesticides with Hodgkin lymphoma. A population-based, case-control study of Hodgkin lymphoma was conducted among males in six regions of Canada. Data were collected by a mailed questionnaire followed by a telephone interview to obtain detailed exposures data for those reporting ≥ 10 hours per year of pesticide exposure. Conditional logistic regression was used to fit statistical models. Comparisons of 316 Hodgkin lymphoma cases and 1506 controls identified several factors as predictors for increased Hodgkin lymphoma risk: family history of cancer, exposure to the insecticide chlorpyrifos [OR (95% CI) = 1.19 (1.03, 1.37)], and previous diagnosis of acne or shingles. The increased risk of developing Hodgkin lymphoma detected among Canadian men who used chlorpyrifos must be interpreted cautiously; however the strength of its association indicates that it requires investigation in other populations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Hodgkin Lymphoma and Pesticides Exposure in Men: A Canadian Case-Control Study

Karunanayake

Spinelli

McLaughlin

et al. 2012

Journal of Agromedicine

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“…[2][3][4] Besides being at risk for injury, farmers are also at risk for developing cancers and neurodegenerative or respiratory disorders as a result of occupational hazards. 5,6 Other reported health hazards and impairments include hearing loss, 7 arthritis, 8 and skin diseases. 9,10 Increased incidence of mental stress and mental illness among farmers has been documented.…”

Section: Introduction Backgroundmentioning

confidence: 99%

Community Support Systems for Farmers Who Live With Disability

Friesen

Krassikouva-Enns²,

Ringaert³

et al. 2010

Journal of Agromedicine

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To return to farming following the onset of a disabling injury or health condition is predicated on a supportive environment for the farm owner-operator. The purpose of this study was to examine barriers and facilitators of returning to work after an injury or acquired disability, and to identify community supports (formal and informal) needed and available to farmers. This was a qualitative study using a participatory action research approach that involved a research team, an advisory group of seven stakeholder participants and semistructured interviews with farmers, their spouses, and service providers in the study communities. A total of 11 farmers and 17 service providers took part in a focus group or were interviewed individually with or without the spouse present. Focus group discussions and interviews were transcribed and analyzed using constant comparison method and team consensus of findings. Themes of barriers and facilitators for return to farming were identified as health care services, financial and economic issues, and "hands-on" assistance. Themes were organized into an ecological conceptual diagram depicting barriers and facilitators in the microsystem of the farm family, the mesosystem of the local farming community and regional health jurisdictions, and the macrosystem of the province and/or nation's social, legislative, and economic realities. Enhancing community support systems for farmers who become disabled as a result of injury or illness will require a multilevel system approach that involves health, financial, and labor resources.

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Multiple pesticide exposures and the risk of multiple myeloma in Canadian men

et al. 2013

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Multiple myeloma (MM) has been linked to certain agricultural exposures, including pesticides. This analysis aimed to investigate the association between lifetime use of multiple pesticides and MM risk using two exposure metrics: number of pesticides used and days per year of pesticide use. A frequency-matched, population-based case-control study was conducted among men in six Canadian provinces between 1991 and 1994. Data from 342 MM cases and 1,357 controls were analyzed using logistic regression to calculate odds ratios (OR) and 95% confidence intervals. Pesticides were grouped by type, chemical class and carcinogenic potential, using a composite carcinogenic probability score. Selected individual pesticides were also examined. Regression models were adjusted for age, province of residence, use of proxy respondents, smoking and selected medical history variables. The overall pattern of results was complex. Positive trends in risk were observed for fungicides (p trend 50.04) and pesticides classified as probably carcinogenic or higher (p trend 50.03). Excess risks of MM were observed among men who reported using at least one carbamate pesticide (OR51.94, 1.16-3.25), one phenoxy herbicide (OR51.56, 1.09-2.25) and 3 organochlorines (OR52.21, 1.05-4.66). Significantly higher odds of MM were seen for exposure to carbaryl (OR52.71, 1.47-5.00) and captan (OR52.96, 1.40-6.24). Use of mecoprop for >2 days per year was also significantly associated with MM (OR52.15, 1.03-4.48). Focusing on multiple pesticide exposures is important because this more accurately reflects how exposures occur in occupational settings. Significant associations observed for certain chemical classes and individual pesticides suggest that these may be MM risk factors.

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Hodgkin Lymphoma, Multiple Myeloma, Soft Tissue Sarcomas, Insect Repellents, and Phenoxyherbicides

Abstract: The mechanisms by which phenoxyherbicides contribute to the risk of multiple myeloma and non-Hodgkin lymphoma may be different.

Cited by 23 publications

References 73 publications

Hodgkin Lymphoma and Pesticides Exposure in Men: A Canadian Case-Control Study

Hodgkin Lymphoma and Pesticides Exposure in Men: A Canadian Case-Control Study

Community Support Systems for Farmers Who Live With Disability

Multiple pesticide exposures and the risk of multiple myeloma in Canadian men

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