Hodgkin Lymphoma Outcome: A Retrospective Study from 3 Tertiary Centers in Saudi Arabia

Shafi, Rehana; Al‐Μansour, Mubarak; Kanfar, Solaf; Hashmi, Hani Al; Alsaeed, Ahmed; Al‐Foheidi, Meteb; Ibrahim, Ezzeldin M.

doi:10.1159/000460819

Cited by 15 publications

(19 citation statements)

References 37 publications

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“…Malignant lymphoma was predominantly perceived in males compared to females. Studies from Saudi Arabia and other countries have shown similar findings [16] [17]. In this study, approximately 83.3% of the cases of HL were males, which is very high percentage compared to other reports [16].…”

Section: Discussionsupporting

confidence: 83%

Epidemiology and Patterns of Malignant Lymphoma in Northern Saudi Arabia

Elasbali¹,

Alharbi²,

Alonzi³

et al. 2018

OJBD

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Objective: The objective of this study was to appraise the epidemiology and patterns of malignant lymphoma in Northern Saudi Arabia. Methodology: A full reportage of data regarding malignant lymphoma was retrieved from the King Khalid Hospital, Hail, Northern Saudi Arabia, comprising records of malignant lymphoma from 2009 to 2016. Results: A review of 120 blood cancers records revealed 47/120 (39.2%) cases of lymphomas, 39 (83%) were Non-Hodgkin lymphoma (NHL), 6 (12.8%) were HL and 2 (4.2%) B-cell lymphomas. The overall crude incidence rate CIR) of lymphomas (from 2009 to 2016) was 6.7 per 100,000 persons of the Hail region population. The mean CIR per year was 0.84 per 100,000 persons. Conclusion: The prevalence of malignant lymphoma is relatively higher in northern Saudi Arabia with predominance of NHL amongst elder population.

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Section: Discussionsupporting

confidence: 83%

Epidemiology and Patterns of Malignant Lymphoma in Northern Saudi Arabia

Elasbali¹,

Alharbi²,

Alonzi³

et al. 2018

OJBD

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“…However, it may recur after the age of 50 years. In one study from Saudi Arabia, the overall survival rate of patients with HL was found to be 91% [59] . Recent studies showed that infection with hepatitis C&B viruses is a common risk factor [60] .…”

Section: Resultsmentioning

confidence: 99%

“…The OR (95%CI) ranged from 1.0 (0.60–1.80) to 5.5 (3.97–7.92). Two studies have assigned genetic and Epstein-Barr viral infection as a possible risk factor for Hodgkin and non-Hodgkin lymphoma, OR (95%CI) 5.5 (3.9–8.0) and 5.8 (4.9–7.0) [19] , [59] . A high degree of heterogeneity was observed in the present analysis (I 2 = 92.6%; p < 0.001).…”

Section: Resultsmentioning

confidence: 99%

Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis<span style="font-size: 12px"> Running title: epidemiology of cancer in Saudi Arabia thru 2010–2019</span>

et al. 2020

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Background Cancer is emerging as a major global health-care system challenge with a growing burden worldwide. Due to the inconsistent cancer registry system in Saudi Arabia, the epidemiology of cancer is still dispersed in the country. Consequently, this review aimed to assemble the epidemiological metrics of cancer in Saudi Arabia in light of the available published data during the period from (2010–2019). Methods Published literature from Saudi Arabia relating to cancer incidence, prevalence, risk factors, and other epidemiological metrics were accessed through electronic search in Medline/PubMed, Cochrane, Scopus, Web of Knowledge, Google Scholar, and public database that meet the inclusion criteria. Relevant keywords were used during the electronic search about different types of cancers in Saudi Arabia. No filters were used during the electronic searches. Data were pooled and odds ratios (ORs) and 95% confidence interval (95%CI) were calculated. A random-effects meta-analysis was performed to assess the well-determined risk factors associated with different types of cancers. Results The most common cancers in Saudi Arabia are breast, colorectal, prostate, brain, lymphoma, kidney and thyroid outnumbering respectively. Their prevalence rates and OR (95%CI) as follow: breast cancer 53% and 0.93 (0.84–1.00); colon-rectal cancer (CRC) 50.9% and 1.2 (0.81–1.77); prostate cancer 42.6% and 3.2 (0.88–31.11); brain/Central Nervous System cancer 9.6% and 2.3 (0.01–4.2); Hodgkin and non-Hodgkin's lymphoma 9.2% and 3.02 (1.48–6.17); kidney cancer 4.6% and 2.05 (1.61–2.61), and thyroid cancer 12.9% and 6.77 (2.34–19.53). Conclusion Within the diverse cancers reported from Saudi Arabia, the epidemiology of some cancers magnitude 3-fold in the latest years. This increase might be attributed to the changing in the Saudi population lifestyle (adopting western model), lack of cancer awareness, lack of screening & early detection programs, social barriers toward cancer investigations. Obesity, genetics, sedentary lifestyle, tobacco use, viral infection, and iodine & Vit-D deficiency represent the apparent cancer risk factors in Saudi Arabia.

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“…Other studies from Europe have reported similar figures [ 7 , 32 ]. In contrary, at least more than half of HL patients in developing countries are diagnosed with advanced stage disease [ 9 , 10 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Overview and outcome of Hodgkin’s Lymphoma: Experience of a single developing country’s oncology centre

Shamoon

Ali²,

Shabila

2018

PLoS ONE

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Hodgkin’s Lymphoma (HL) reveals variable epidemiological and clinico-pathological features in different geographical locations. In this retrospective study, we aimed to assess the epidemiological and clinic-pathological features, and outcome of HL patients treated at one hemato-oncology centre in Erbil, northern Iraq. Medical records of 103 HL patients treated over more than six years were reviewed. Treatment outcome was evaluated by measuring the 5-year overall and progression-free survival rates. The median age of patients was 23 years, children up to 17 years constituted 31.1%, and male to female ratio was 1:1.05. The majority (96.1%) of patients presented with lymphadenopathy. Nodular sclerosis subtype was the mostly encountered histologic type (48.5%); about half of the patients (49.5%) had stage II disease. Relapse occurred in 20 patients; the 5-year overall survival for children was better (89%) compared to adult patients (79%). The associated risk features found to have adverse effects on the survival, however, only high LDH level and presence of B-symptoms at presentation showed significant correlation. The epidemiological and clinical characteristics of HL in our locality followed the pattern in the western world. The 5-year overall and progression-free survivals were far below the international rates, a matter which may necessitate a revision to HL treatment strategy at our centre.

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Hodgkin Lymphoma Outcome: A Retrospective Study from 3 Tertiary Centers in Saudi Arabia

Cited by 15 publications

References 37 publications

Epidemiology and Patterns of Malignant Lymphoma in Northern Saudi Arabia

Epidemiology and Patterns of Malignant Lymphoma in Northern Saudi Arabia

Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis<span style="font-size: 12px"> Running title: epidemiology of cancer in Saudi Arabia thru 2010–2019</span>

Overview and outcome of Hodgkin’s Lymphoma: Experience of a single developing country’s oncology centre

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