Hodgkin lymphoma presenting with exclusive or preponderant pulmonary involvement: a clinicopathologic study of 5 new cases

Rodríguez, J. M. Martínez; Tirabosco, Roberto; Pizzolitto, Stefano; Rocco, Maurizio; Falconieri, Giovanni

doi:10.1016/j.anndiagpath.2005.07.014

Cited by 29 publications

(26 citation statements)

References 13 publications

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“…In addition, immunocytochemistry (ICC) for cytokeratin, S100 protein, and CD30 may help resolve these differentials. 5,6 Even though we could not do ICC for CD30 on the air-dried smears, we have seen CD30 positivity in wet-fixed smears in nodal aspirates from HL. We suggest that performing ICC could help in confusing cases when sufficient material is available.…”

Section: Discussionmentioning

confidence: 85%

“…4,5 Some nonneoplastic conditions like Wegener granulomatosis, hypersensitivity pneumonia, lymphoid interstitial pneumonia, eosinophilic pneumonia, and extrinsic allergic alveolitis show reactive type II pneumocytes that could be mistaken for RS cells. [4][5][6] Correlating with clinical presentation will help in the correct diagnosis in these cases.…”

Section: Discussionmentioning

confidence: 96%

“…[16][17][18][19][20] If the RS cells are identified they may be interpreted as reactive pneumocytes or bronchiolar epithelial cells and sometimes even as large cell carcinoma or melanoma given their large atypical nuclei. 6 However, the presence of a polymorphous background, large connective tissue fragments with entrapped large nucleolated (RS) cells with discohesion, and apoptosis help in the correct diagnosis. Absence of cohesive sheets and background mucin are negative pointers toward the cytologic diagnosis of carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…On radiology a PPHL has propensity to arise in the superior portions of the lung, whereas secondary pulmonary involvement by a systemic HL shows random miliary distribution without zonal predilection. 5,6 HL has always been a difficult cytologic diagnosis even at nodal locations.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6] Fewer than 100 cases of PPHL have been reported in the literature, either as individual case reports or as small series. [2][3][4][5][6][7][8][9][10][11] Transthoracic fine needle aspiration cytology (FNAC) plays a crucial role in the diagnosis and management of patients with hematolymphoid malignancies, helping to avoid unnecessary excisions. PPHL needs to be distinguished from the commonly encountered neoplastic and nonneoplastic conditions of the lung.…”

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confidence: 97%

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Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Kumar

Sidhu

Mistry

et al. 2008

Diagnostic Cytopathology

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Primary pulmonary Hodgkin's lymphoma (PPHL) is extremely rare. At an extranodal location such as the lung this lymphoma is likely to be confused with the more commonly occurring carcinomas at this site. We report the fine needle aspiration cytology (FNAC) findings of a PPHL in a 36-year-old male with a view to discuss the pitfalls and clues to the accurate cytologic diagnosis. This patient presented with a large, heterogeneously enhancing mass involving the anterior segment of right upper lobe without any evidence of nodal involvement. A CT-guided transthoracic FNAC of this mass revealed large connective tissue fragments with entrapped voluminous cells amidst a polymorphous population of eosinophils, polymorphs, and lymphocytes. The large cells showed abundant often stripped off cytoplasm, an irregular nucleus with nucleolus and were initially diagnosed as non-small cell carcinoma of the lung. In view of the locally advanced stage, patient received a carboplatin and gemcite-based chemotherapy with complete response but postchemotherapy patient refused local surgery. Two years later, the patient developed enlarged nodes which were diagnosed as Hodgkin's lymphoma, and a review of prior lung tumor confirmed the diagnosis of PPHL. Hence the rare diagnosis of PPHL should be kept in mind when a cytopathologist observes large cells embedded in collagenous tissue fragments with dominant cell dispersal amidst an inflammatory infiltrate in an aspirate from a primary lung tumor.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

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Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Kumar

Sidhu

Mistry

et al. 2008

Diagnostic Cytopathology

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Primary pulmonary classical Hodgkin lymphoma: A case report

Schild

Wong

Valdez

et al. 2014

Journal of Surgical Oncology

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Primary pulmonary Hodgkin lymphoma (PPHL) is a rare entity. Most reported cases occurred before the availability of PET scan for accurate staging of the disease. We report a case of PPHL for which PET/CT scan was used and surgery was performed to confirm the diagnosis. A review of cases of PPHL since 1990 suggests that adjuvant chemotherapy and/or radiation therapy after surgical resection of the lung lesions achieve better disease control than surgical resection alone. J. Surg. Oncol. 2014 110:341–344. © 2014 Wiley Periodicals, Inc.

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Respiratory tract

2011

Rosai and Ackerman's Surgical Pathology

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Hodgkin lymphoma presenting with exclusive or preponderant pulmonary involvement: a clinicopathologic study of 5 new cases

Cited by 29 publications

References 13 publications

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Primary pulmonary classical Hodgkin lymphoma: A case report

Respiratory tract

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