Hodgkin's disease in Indian children: Outcome with chemotherapy alone

Abstract

Chemotherapy alone with alternating COPP/ABVD, without additional radiotherapy, provides high rates of durable remission and is an effective therapy in childhood HD, even in case of large mediastinal mass and peripheral or abdominal bulky disease.

A Clinicopathological Study of Spectrum of Pediatric Malignancies in North India Region

“…Lymphoma and leukemia (28.33 % each) having equal incidence followed by retinoblastoma and bone tumor (11.66 %), soft tissue tumor (8.33 %) CNS tumors (5.0 %). Our results were comparable to most other Indian studies as shown in (5) , 6.15 % Bangalore Registry, 4.65 % by Mumbai Registry, 5.70 % by Delhi Registry). Similarly incidence of malignant soft tissue tumor in our study were comparable with other Indian studies as shown in Table 6.…”

The treatment of childhood Hodgkin lymphoma: Improved survival in a developing country

“…In some studies, chemotherapy alone was used as the initial treatment [3,12,24]. In a study by Ertem et al [3] every patient received chemotherapy for the initial treatment, including the COPP, ABVD, and ABVD regimens alternating with COPP, to be given as a total of 12 courses.…”

Risks and diagnosis of coronary artery disease in Hodgkin lymphoma survivors

“…In contrast, in our country and most of the developing parts of the World lymphomas just follow the leukemias in frequency [32] . With advanced diagnostic and therapeutic facilities the survival rates in low and high risk patients with HL increased to 95% and 90% respectively [33,34] . Similarly, improved results after HL treatment were also published in articles from Turkey in recent years [35,36] .…”

“…The mostly used chemotherapeutic regimens in HL are mechlorethamine, vincristine, prednisone and procarbazine (MOPP), cyclophosphamide, vincristine, prednisone and procarbazine (COPP), doxorubicin, bleomycin, vinblastine, dacarbazine (DBVD), OPPA (vincristine, procarbazine, prednisone, adriamycin), and MOPP/DBVD alternating protocols [33,34] . Among the acute side effects of multiagent chemotherapy protocols nausea and vomiting are the leading ones.…”

“…Radiation pneumonitis, pulmonary fibrosis, spontaneous pnemothorax, abnormalities in growing soft tissues and bones, cardiovascular, and endocrine abnormalities constitute the late effects of treatment. Second malignant neoplasms, especially ALL, are also among the late effects of therapy [33,34,[37][38][39] . Antineoplastic drugs, especially anthracyclines and mediastinal radiotherapy can cause decrease in cardiac contractility, heart insufficiency, pericardial effusion, constrictive pericarditis, coronary artery disease, myocardial infarction, and arrhythmias [15][16][17][18][19]40] .…”