Hodgkin's disease in Western India review of 1082 cases

Talvalkar, G V; Sampat, M. B.; Gangadharan, P

doi:10.1002/1097-0142(19820715)50:2<353::aid-cncr2820500232>3.0.co;2-#

Cited by 19 publications

(13 citation statements)

References 2 publications

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“…Primary lymph nodeneoplasm, i.e., Hodgkin's disease and non-Hodgkin's lymphoma, constitutes more than 50% of these cases, with metastatic carcinoma or sarcoma accounting for the remainder. Hodgkin's disease constituted 48.8% of all the primary neoplasms, in agreement with the statistics reported for other countries, [26][27][28][29][30] though higher than earlier findings in Saudi Arabia. 31 Mixed cellularity was the most common type, and this is the finding for other developing countries [30][31][32][33][34][35] but is in contrast to that reported for developed countries where the nodular sclerosis is the most common type.…”

Section: Discussionsupporting

confidence: 90%

Histologic Patterns of Lymphadenopathy in the Eastern Province of Saudi Arabia

et al. 1990

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Section: Discussionsupporting

confidence: 90%

Histologic Patterns of Lymphadenopathy in the Eastern Province of Saudi Arabia

et al. 1990

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“…The most common histopathological types occurring in our region are the MC and LP types, as documented in earlier publications [7,8]. Thus the inclusion in this study of 42% of the MC and 38% of LP subtypes has clinical relevance.…”

Section: Discussionsupporting

confidence: 61%

The relevance of a staging laparotomy for Hodgkin's disease in India

Dinshaw

Pande

Shrivastava

et al. 1992

Journal of Surgical Oncology

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A retrospective analysis of 328 cases of Hodgkin's Disease (HD) subjected to a staging laparotomy at the Tata Memorial Hospital, Bombay, India, from 1974 to 1986 was undertaken to assess its relevance to our setup. Eighty percent of the patients were from clinical stages (CS) I and II, 38% with lymphocyte predominance (LP), and 41% with mixed cellularity (MC) histologies. Staging laparotomy was positive in 60% cases overall, including 50% from CS IA and IIA, 68% from CS IB and IIB, and 53% and 67%, respectively, from LP and MC histologies. Splenic involvement was seen in 54% cases. Operative complications were encountered in 2% of cases and deaths in two cases only. In view of the high propensity for abdominal spread, only selected CS IA and IIA cases would merit a staging laparotomy within which, nearly 50% cases with a negative yield could be offered radical segmental irradiation alone for cure. The majority of our patients would, however, require combination therapy.

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“…These fi ndings were in contrast to the observation of Ramani et al [4] where mediastinal lymph node involvement was found to be more common. The most common subtype of HL noted in our study was mixed cellularity followed by [3,4,7]. In contrast nodular sclerosis variant is the most common subtype (51%) followed by mixed cellularity (23.8%) in a large western registry [8].…”

Section: Discussionmentioning

confidence: 62%

“…HL have been classifi ed separately from other lymphomas because of its specifi c identifying cell, limited morphological range together with its distinctive clinical features, and difference in classifi cation, staging and outcome. Even among the patients of HL, geographic variation in respect of histologic sub-types, extent of disease at the time of diagnosis, and consequent variations in the treatment responses are well-documented [2,3]. Only a few studies have been undertaken in India that describes the clinicopathologic profi le of lymphomas among the rural population [4].…”

Section: Introductionmentioning

confidence: 99%

Clinico-pathologic profile of Hodgkin’s lymphoma in a rural medical college

Goswami

Sarkar

Chakrabarti

et al. 2008

Indian J Hematol Blood Transfus

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Purpose of study A prospective study was done at North Bengal Medical College and Hospital (NBMCH), Darjeeling, West Bengal, which caters predominantly to the rural and hilly population. All patients diagnosed as Hodgkin's lymphoma (HL) were analyzed for clinical presentation, histological classifi ed and staging.Results Total of 48 cases reported for HL were studied (n=48). A lower median age of onset (28.1year) and higher male to female ratio (3.8:1) as compared to western countries were observed. We found neck swelling was the commonest presenting symptom (58.28%) and peripheral lymphadenopathy was the commonest sign (83.33%). "B symptoms" was noted in 79.17% cases. Cervical lymph nodes were commonly involved (79.17%), followed by inguinal (45.83%) and axillary (29.17%). Thoracic lymph nodes and abdominal lymph nodes were enlarged in 29.17% of the cases and 25% of the cases respectively. Eosinophilia was noted in 29.17% of cases. Marrow involvement by neoplastic process was observed in 8.33% of cases and reactive changes in the marrow were observed in 12.5% of cases.We found mixed cellularity subtypes was the commonest (45.83%) followed by nodular sclerosis subtypes (33.33%). At presentation 54.17% of cases were of advanced stage of disease (stage III and IV). ConclusionWe noticed a distinct geographical pattern of HL in respect of age, sex, presentation, histological typing and staging of the disease, which is comparable to some other Indian studies but is noticeably different from patterns noted in Western countries.

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Hodgkin's disease in Western India review of 1082 cases

Cited by 19 publications

References 2 publications

Histologic Patterns of Lymphadenopathy in the Eastern Province of Saudi Arabia

Histologic Patterns of Lymphadenopathy in the Eastern Province of Saudi Arabia

The relevance of a staging laparotomy for Hodgkin's disease in India

Clinico-pathologic profile of Hodgkin’s lymphoma in a rural medical college

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