Hodgkin's Disease Involving the Central Nervous System

Central nervous system involvement in Hodgkin's lymphoma is extremely rare. We report three cases who had a relapse from the disease involving CNS. The most frequent causes are skull contiguity, meningeal invasion and via the hematogenous route. It is frequent that the association between Epstein-Barr Virus and Hodgkin's lymphoma, and a biopsy for confirmation, is always required. Diagnostic imaging tests like CT and MRI are useful. The standard treatment remains holocraneal radiotherapy combined with chemotherapy.

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“…There are few cases reported in the literature [13,[19][20][21][22][23], the biggest series of cases reported 6 patients [8].…”

Section: Discussionmentioning

confidence: 99%

Central nervous system involvement in Hodgkin’s lymphoma

et al. 2010

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“…Event hough the patient's epileptic convulsions gradually decreased in frequency and ceased following radiotherapy, other neurological symptoms persisted and were progressive; therefore the patient underwent physiotherapy for paraplegia. The patient was treated with 1 cycle of ifosfamide, carboplatin, and etopo-via cranial and meningeal involvement [6][7][8], or via the hematogenous route [9][10][11]. Neurological hydrocephaly occurred together with leptomeningeal involvement in the presented case.…”

Section: Cranial Brain Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Hodgkin's lymphoma with leptomeningeal involvement

Yildirim¹,

Gündoğdu²,

Erdem³

et al. 2011

Turk J Hematol

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A 31-year-old male patient with Hodgkin's lymphoma (Hl) and leptomeningeal involvement presented to at Hematology departments of Atatürk University . The patient developed dizziness, limb weakness, involuntary contractions of the hands and feet, incontinence, headache, fever, nausea, and vomiting following the first cycle of treatment with the ABVd protocol (adriamycin 25 mg m ⎯2, bleomycin 10 mg m ⎯2, vinblastin 6 mg m ⎯2 , and dacarbazine 375 mg m ⎯2 on d 1 and 15 of a 28-d cycle). magnetic resonance imaging (mRı) showed that there were regions with infiltration in particularly the thoracic vertebrae (T3, T4, T9, and T10-T12). ın the lumbar region leptomeningeal involvement beginning at the end of the medulla spinalis that gave rise to a separation of nerves in the cauda equine was observed. Contrast agent uptake was observed, especially at the dural sac, with edema in the nerve roots.Key Words: leptomeningeal involvement, Hodgkin's lymphoma Özet Otuz bir yaşında leptomeningeal tutulumu olan Hodgkin's lenfoma (Hl)'lı erkek hasta sunuldu. Hastada, ABVd (Adriamycin 25 mg/m2, bleomycin 10 mg/m2, vinblastine 6 mg/m2, dacarbazine 375 mg/m2 on days 1 and 15 of a 28-day cycle) tedavisinin ilk siklusundan sonra baş dönmesi, ekstremitelerde güçsüzlük, el ve ayaklarda istemsiz kasılma, inkontinans, baş ağrısı, ateş, bulantı ve kusma gelişti. magnetic resonance imaging (mRı)'da özellikle torakal vertebralarda (T3, T4, T9, T10-T12), infiltrasyon ile uyumlu alanlar görüldü. lomber bölgede medulla spinalisin son kısmından başlayan, kauda equinadaki sinirlerde ayrılmaya sebep olan leptomeningeal tutulum görüldü. Sinir köklerinde ödem ile birlikte özellikle dural kesede kontrast madde tutulumu görüldü.Anahtar Sözcükler: leptomeningeal tutulum, Hodgkin lenfoma

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“…2 Intracranial involvement is rare and presents as a late manifestation, usually with supratentorial predilection. [4][5][6] The association between Down syndrome and HL is uncommon with only six cases reported to date, most occurring in young males. 7 Risk factors for intracranial HL have not been determined, although some reports have suggested an increased involvement of CNS with mixed cellularity histology in up to 44% of cases reported.…”

Section: Hodgkin's Lymphoma Involving the Cnsmentioning

confidence: 99%