Hodgkin's disease with leptomeningeal involvement: Report of a case with long survival

Orlowski, Edward P.; Hansen, Richard M.; Anderson, Tom; Hanson, Gerald A.; Kun, Larry E.; Pisciotta, Anthony V.

doi:10.1002/1097-0142(19840501)53:9<1833::aid-cncr2820530905>3.0.co;2-0

Cited by 19 publications

(8 citation statements)

References 6 publications

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“…8 Recurrent Hodgkin's disease or a second malignancy could show similar MRI abnormalities. 10 The absence of malignant cells on CSF cytologic examination, the slow and stabilizing course, and an unchanging MRI over time rule out malignant infiltration. 9 Furthermore, Hodgkin's disease is rarely associated with leptomeningeal dissemination.…”

mentioning

confidence: 99%

Post-irradiation polyradiculopathy mimics leptomeningeal tumor on MRI

Hsia¹,

Katz²,

Hancock³

et al. 2003

Neurology

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mentioning

confidence: 99%

Post-irradiation polyradiculopathy mimics leptomeningeal tumor on MRI

Hsia¹,

Katz²,

Hancock³

et al. 2003

Neurology

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“…Following radiotherapy, cytological analysis and cytocentrifugation of the patient's cerebrospinal fluid showed that there were no cells, whereas biochemical analysis showed an increase in microprotein levels and a decrease in the glucose level, suggesting leptomeningeal involvement. According to previous reports, remission can be achieved with intrathecal chemotherapy and cranial radiotherapy in patients with leptomeningeal involvement [15], although it was not achieved in the presented patient.…”

Section: Cranial Brain Magnetic Resonance Imaging (Mri)mentioning

confidence: 51%

Hodgkin�s Lymphoma with Leptomeningeal Involvement

Yildirim¹,

Gündoğdu²,

Erdem³

et al. 2012

Turk J Hematol

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A 31-year-old male patient with Hodgkin's lymphoma (Hl) and leptomeningeal involvement presented to at Hematology departments of Atatürk University . The patient developed dizziness, limb weakness, involuntary contractions of the hands and feet, incontinence, headache, fever, nausea, and vomiting following the first cycle of treatment with the ABVd protocol (adriamycin 25 mg m ⎯2, bleomycin 10 mg m ⎯2, vinblastin 6 mg m ⎯2 , and dacarbazine 375 mg m ⎯2 on d 1 and 15 of a 28-d cycle). magnetic resonance imaging (mRı) showed that there were regions with infiltration in particularly the thoracic vertebrae (T3, T4, T9, and T10-T12). ın the lumbar region leptomeningeal involvement beginning at the end of the medulla spinalis that gave rise to a separation of nerves in the cauda equine was observed. Contrast agent uptake was observed, especially at the dural sac, with edema in the nerve roots.Key Words: leptomeningeal involvement, Hodgkin's lymphoma Özet Otuz bir yaşında leptomeningeal tutulumu olan Hodgkin's lenfoma (Hl)'lı erkek hasta sunuldu. Hastada, ABVd (Adriamycin 25 mg/m2, bleomycin 10 mg/m2, vinblastine 6 mg/m2, dacarbazine 375 mg/m2 on days 1 and 15 of a 28-day cycle) tedavisinin ilk siklusundan sonra baş dönmesi, ekstremitelerde güçsüzlük, el ve ayaklarda istemsiz kasılma, inkontinans, baş ağrısı, ateş, bulantı ve kusma gelişti. magnetic resonance imaging (mRı)'da özellikle torakal vertebralarda (T3, T4, T9, T10-T12), infiltrasyon ile uyumlu alanlar görüldü. lomber bölgede medulla spinalisin son kısmından başlayan, kauda equinadaki sinirlerde ayrılmaya sebep olan leptomeningeal tutulum görüldü. Sinir köklerinde ödem ile birlikte özellikle dural kesede kontrast madde tutulumu görüldü.Anahtar Sözcükler: leptomeningeal tutulum, Hodgkin lenfoma

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“…There are few cases reported in the literature [13,[19][20][21][22][23], the biggest series of cases reported 6 patients [8].…”

Section: Discussionmentioning

confidence: 99%

Central nervous system involvement in Hodgkin’s lymphoma

et al. 2010

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Central nervous system involvement in Hodgkin's lymphoma is extremely rare. We report three cases who had a relapse from the disease involving CNS. The most frequent causes are skull contiguity, meningeal invasion and via the hematogenous route. It is frequent that the association between Epstein-Barr Virus and Hodgkin's lymphoma, and a biopsy for confirmation, is always required. Diagnostic imaging tests like CT and MRI are useful. The standard treatment remains holocraneal radiotherapy combined with chemotherapy.

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Hodgkin's disease with leptomeningeal involvement: Report of a case with long survival

Cited by 19 publications

References 6 publications

Post-irradiation polyradiculopathy mimics leptomeningeal tumor on MRI

Post-irradiation polyradiculopathy mimics leptomeningeal tumor on MRI

Hodgkin�s Lymphoma with Leptomeningeal Involvement

Central nervous system involvement in Hodgkin’s lymphoma

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