Abstract:The thermal decomposition of tetraalkylammonium hydroxide to form an olefin and a tertiary amine is generally known as the Hofmann elimination. As the nature of pyrolysis, the Hofmann elimination is often carried out in a solvent with a high boiling point. The anti‐elimination predominates on six‐membered rings. However, a few exceptions that proceed E2 elimination via the
cis
transition state are also known due to the enhanced acidity of proton, or conformational or steric hindrance. F… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.