Thermomechanical fatigue (TMF) crack growth of Alloy 718 when the cycle includes long high‐temperature tensile dwells is often accelerated because sustained‐load crack growth occurs during the dwells and a temperature affected zone (TAZ) develops ahead of a crack tip that reduces fatigue crack growth resistance upon application of a cycle after the long dwell. This paper presents new TMF and sustained‐load tests that aim to study and characterize the TAZ development and growth ahead of semi‐elliptical and single‐edge cracks. The influence of constraint on crack growth is assessed. This investigation focuses on a coarse‐grained (CG) Alloy 718 at 650°C. By comparing the crack growth behavior between a fine‐grained and CG microstructure after a long tensile dwell, a modification of the TAZ growth prediction model that includes the influence of grain size is proposed. Using this improved model for TAZ growth and acceleration, the TMF crack growth prediction of surface cracks is improved.