In the Chinese cultural context, music is deeply intertwined with the human heart and plays a central role in both healing and governance. Guqin, an ancient Chinese zither, exemplifies holistic care throughout history, embodying heart-based empathy and resonance. This study draws on insights from traditional Chinese medicine (TCM), classic philosophy, literature, and aesthetics to trace a lineage of thinking that continues to inform contemporary music therapy. We examine the Chinese notion of xin/heart and the interdependent self, and how music facilitates individuals’ aesthetic attunement toward the natural and social orders. Our approach transcends limitations of Euro-American psychological paradigms centered on the psyche, by adopting a holistic perspective that emphasizes the interconnectedness of the heart, the body, and the cosmos. We argue for the necessity of moving beyond reductive biomedical treatment models to explore alternative ways of living and alternative care that highlight relational, moral, and aesthetic approaches to well-being.