Holistic Regulation of Angiogenesis with Chinese Herbal Medicines as a New Option for Coronary Artery Disease

Abstract

Effectively improving myocardial blood flow and controlling atherosclerotic plaque have always been key and difficult points in the prevention and treatment of coronary artery disease (CAD). Although “therapeutic angiogenesis” is regarded as a promising approach for ischemic heart disease by improving blood flow, angiogenesis itself can induce the destabilization of atherosclerotic plaque, which reflects the double-edged role of angiogenesis. Modulating the balance of angiogenesis can be an important target for CAD treatment. Traditional Chinese medicine (TCM) emphasizes the holistic view and dynamic balance of the body. Furthermore, the principle of activating blood circulation and removing blood stasis (ABCRS) is closely connected with angiogenesis and CAD. Recent research suggests that Chinese herbal medicines for ABCRS are effective in balancing the regulation of angiogenesis. This review presents the progress of recent research on the angiogenesis regulation with Chinese herbal medicines for ABCRS in CAD. Moreover, this review demonstrates that Chinese herbal medicines for ABCRS can not only promote angiogenesis in the ischemic area to improve myocardial blood flow but also alleviate angiogenesis to stabilize plaque in atherosclerosis, which reflects the holistic regulatory role in CAD treatment.

The efficacy and safety of Shenzhu Guanxin Recipe Granules for treatment of patients with coronary artery disease: protocol for a double-blind, randomized controlled trial

“…Although the treatment of CAD has remarkably advanced, the treatment of ICL has still remained controversial. Chinese herbs had been proved to have definite curative effects on CAD and gradually attracted scholars' attention in clinical trials [23][24][25]. Furthermore, SGR had been proved to be effective for patients with angina pectoris after PCI, and it can also upregulate the expression of platelet/endothelial cell adhesion molecule-1 (PECAM-1)/CD31 and vascular endothelial growth factor (VEGF), thereby promoting myocardium angiogenesis in myocardial infarction rats [26].In this study, we attempted to further investigate the efficacy and safety of SGR in patients with ICL, in which CCS was used as an indicator to evaluate the efficacy.…”

The efficacy and safety of Shenzhu Guanxin Recipe Granules for treatment of patients with coronary artery disease: protocol for a double-blind, randomized controlled trial

“…Although the treatment of CAD has remarkably advanced, the treatment of ICL has still remained controversial. Chinese herbs had been proved to have definite curative effects on CAD and gradually attracted scholars' attention in clinical trials [23][24][25]. Furthermore, SGR had been proved to be effective for patients with angina pectoris after PCI, and it can also upregulate the expression of platelet/endothelial cell adhesion molecule-1 (PECAM-1)/CD31 and vascular endothelial growth factor (VEGF), thereby promoting myocardium angiogenesis in myocardial infarction rats [ 26].In this study, we attempted to further investigate the efficacy and safety of SGR in patients with ICL, in which CCS was used as an indicator to evaluate the efficacy.…”

The efficacy and safety of Shenzhu Guanxin Recipe Granules for treatment of patients with coronary artery disease: protocol for a double-blind, randomized controlled trial

“…The database will be built by EpiData 3.1 software. In this study, SPSS 22.0 software (IBM, Armonk, NY, USA) was used to perform statistical analysis. Continuous variables were expressed as mean ± standard deviation (SD) or median, and categorical variables were reported as numbers and percentages.…”

“…Although the treatment of CAD has remarkably advanced, the treatment of ICL has still remained controversial. Chinese herbs had been proved to have definite curative effects on CAD and gradually attracted scholars' attention in clinical trials [20][21][22]. Furthermore, SGR had been proved to be effective for patients with angina pectoris after PCI, and it can also upregulate the expression of platelet/endothelial cell adhesion molecule-1 (PECAM-1)/CD31 and vascular endothelial growth factor (VEGF), thereby promoting myocardium angiogenesis in myocardial infarction rats [23].In this study, we attempted to further investigate the efficacy and safety of SGR in patients with ICL, in which CCS was used as an indicator to evaluate the efficacy.…”