Hollow-adjustable polymer microneedles for prolonged hypoglycemic effect on diabetic rats

Liu, Tianqi; Sun, Yanfang; Zhang, Wenjing; Wang, Rui; Lv, Xinyu; Nie, Lei; Shavandi, Amin; Yunusov, Khaydar E.; Jiang, Guohua

doi:10.1016/j.cej.2024.148670

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.148670

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Hollow-adjustable polymer microneedles for prolonged hypoglycemic effect on diabetic rats

Tianqi Liu,

Yanfang Sun,

Wenjing Zhang

et al.

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2024

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Cited by 4 publications

References 69 publications

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Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging

Chen,

Zhang,

Zhang

et al. 2024

Advanced Therapeutics

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Skin aging is characterized by a deterioration of skin quality over time resulting from physiological changes and oxidative stress (OS). Superoxide dismutase (SOD) is an effective antioxidant enzyme widely used as a food supplement and cosmetic additive to alleviate OS and retard skin aging. However, conventional SOD delivery routes commonly yield unsatisfactory results due to limited stability, compromised bioavailability, and low absorption efficiency in the gastrointestinal (GI) tract. These issues are addressed by developing SOD‐encapsulated polymeric microneedle (PMN) patches for efficient transdermal delivery. The use of a highly stable SOD isolated from a hot spring microbe ensures its reactivity throughout PMN fabrication and application. This SOD vehicle demonstrated excellent effectiveness through inhibiting skin‐aging and promoting hair growth as validated by extensive in vivo experiments using D‐galactose (D‐gal) induced aging‐mouse model. SOD‐PMNs promoted excellent regeneration of hair follicles, increased melanin synthesis, decreased lipid oxidation, and elevated antioxidative capacity of skin tissue. The success in effective transdermal delivery of SOD promises wide applicability in pharmaceutical and cosmetic industries.

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Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging

Chen,

Zhang,

Zhang

et al. 2024

Advanced Therapeutics

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Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Haidari,

Bright,

et al. 2024

Small Science

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Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug delivery while complemented with noninvasiveness and patient compliance. Currently, the topical application of antimicrobials restricts the delivery of drugs to the critical areas of the wound bed, largely due to barriers posed by the necrotic tissue, scab formation, and bacterial biofilms, which severely diminish the bioavailability of the therapeutics. MNs have enabled efficient and targeted delivery to overcome many chronic wound challenges. Over the past decade, significant progress has been made to develop MNs with unique properties tailored for the delivery of vaccines, anticancer, and antimicrobials. As ongoing research continues to refine MN design, material properties, and drug formulations, the potential for revolutionizing antimicrobial drug delivery for efficacy, patient experience, and therapeutic outcomes remains at the forefront of scientific research. In this review, insights are provided into the latest progress, current developments, and the diverse applications of MNs for antimicrobial drug delivery. Herein, the translational potential of MNs is highlighted and a perspective on the current challenges associated with clinical translation is provided. Furthermore, this review aids in identifying research gaps while empowering and contributing to the future implementation of cutting‐edge delivery systems to effectively tackle antimicrobial resistance.

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Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

Zhao,

Chen,

Gan

et al. 2024

Nano Res.

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Hollow-adjustable polymer microneedles for prolonged hypoglycemic effect on diabetic rats

Cited by 4 publications

References 69 publications

Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging

Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging

Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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