Hollow core photonic crystal fiber surface-enhanced Raman probe

He, Yonghong; Gu, Changzhi; Yang, Changxi; Liu, Jie; Jin, Guofan; Zhang, Jiatao; Hou, Lantian; Yao, Yuan

doi:10.1063/1.2388937

Cited by 116 publications

(57 citation statements)

References 21 publications

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“…We have achieved a measured detection limit of approximately 400 pM, which is significantly lower than other reported detection limits (10 nM -1 μM) for other designs [8][9][10]. For this detection limit, it is likely that the measured Raman signal is due to no more than a few hundred target analytes on a low number of silver nanoclusters.…”

Section: Summary and Discussionmentioning

confidence: 66%

“…In recent years, microfluidic-based SERS platforms have been demonstrated in which the sample is optically excited inside a small sample delivery channel [7][8][9][10]. In references [7,8], specialized fiber cables are used as both the microfluidic sample delivery mechanism and the Raman pump/signal waveguide, while reference [9] is of particular interest for lab-on-a-chip development, as it uses a liquid core waveguide integrated onto a chip. The resulting detection limits achieved thus far with these approaches are on the order of 10 nM to 1 μM.…”

Section: Introductionmentioning

confidence: 99%

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SERS-based detection in an optofluidic ring resonator platform

2007

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The development of surface enhanced Raman scattering (SERS) detection has made Raman spectroscopy relevant for highly sensitive lab-on-a-chip bio/chemical sensors. Despite the tremendous benefit in specificity that a Raman-based sensor can deliver, development of a lab-ona-chip SERS tool has been limited thus far. In this work, we utilize an optofluidic ring resonator (OFRR) platform to develop a SERS-based detection tool with integrated microfluidics. The liquid core optical ring resonator (LCORR) serves both as the microfluidic sample delivery mechanism and as a ring resonator, exciting the metal nanoclusters and target analytes as they pass through the channel. Using this OFRR approach and R6G as the analyte, we have achieved a measured detection limit of 400 pM. The measured Raman signal in this case is likely generated by only a few hundred R6G molecules, which foreshadows the development of a SERS-based lab-on-a-chip bio/chemical sensor capable of detecting a low number of target analyte molecules.

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Section: Summary and Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

SERS-based detection in an optofluidic ring resonator platform

2007

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“…Coated fibers may be used in gas sensing devices where the fluorescence signal is affected by the concentration of several gases. Furthermore, surface-enhanced Raman scattering [12] can be established as well if metal particles are infiltrated. Furthermore, by functionalization of the core walls and infiltration of biochemical samples, various chemical reaction or biological processes might be monitored.…”

Section: Discussionmentioning

confidence: 99%

Highly efficient fluorescence sensing with hollow core photonic crystal fibers

Smolka¹,

Barth²,

Benson³

2007

Opt. Express

112

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“…This can be overcome by delivering the excitation light to the sample through a hollow-core photonic crystal fiber (PCF), which generates little or no FSB [19,20]. Hollow-core PCFs have also been used for simultaneous pump light delivery and Raman signal collection [21,22]. An alternative to PCFs is given by coaxial double-clad fibers, which combine the advantages of single-and multi-fiber geometries by providing an intrinsic separation between the excitation and collection paths (the core and inner cladding, respectively).…”

Section: Introductionmentioning

confidence: 99%

Raman probes based on optically-poled double-clad fiber and coupler

Brunetti¹,

Margulis²,

Rottwitt³

2012

Opt. Express

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Abstract:Two fiber Raman probes are presented, one based on an optically-poled double-clad fiber and the second based on an opticallypoled double-clad fiber coupler respectively. Optical poling of the core of the fiber allows for the generation of enough 532nm light to perform Raman spectroscopy of a sample of dimethyl sulfoxide (DMSO), when illuminating the waveguide with 1064nm laser light. The Raman signal is collected in the inner cladding, from which it is retrieved with either a bulk dichroic mirror or a double-clad fiber coupler. The coupler allows for a substantial reduction of the fiber spectral background signal conveyed to the spectrometer. References and links1. R. L. McCreery, M. Fleischmann, and P. Hendra, "Fiber optic probe for remote Raman spectrometry," Anal.Chem. 55 (1), 146-148 (1983). 2. I. Lewis and P. Griffiths, "Raman spectrometry with fiber-optic sampling," Appl. Spectrosc. 50, 12A-30A (1996). 3. T. Cooney, H. Skinner, and S. Angel, "Comparative study of some fiber-optic remote Raman probe designs. Part I: Model for liquids and transparent solids," Appl. Spectrosc. 50, 836-848 (1996). 4. T. Cooney, H. Skinner, and S. Angel, "Comparative study of some fiber-optic remote Raman probe designs. Part II: Tests of single-fiber, lensed, and flat-and bevel-tip multi-fiber probes," Appl. Spectrosc. 50, 849-860 (1996). 5. U. Utzinger and R. R. Richards-Kortum, "Fiber optic probes for biomedical optical spectroscopy," J. Biomed.Opt. 8, 121-147 (2003). 6. M.J. Pelletier, "Fiber optic probe with integral optical filtering," USA Patent no. 5862273 (1999). 7. A. C. Brunetti, L. Scolari, T. Lund-Hansen, J. Weirich, and K. Rottwitt, "All-in-fiber Rayleigh-rejection filter for Raman spectroscopy," Electron. Lett. 48(5), 275-276 (2012). 8. B. Redding and H. Cao, "Using a multimode fiber as a high-resolution, low-loss spectrometer," Opt. Lett. 37(16), 3384-3386 (2012). 9. V. Pruneri, G. Bonfrate, P. G. Kazansky, D. J, Richardson, N. G. Broderick, J. P. de Sandro, C. Simonneau, P.Vidakovic, and J. A. Levenson, "Greater than 20%-efficient frequency-doubling of 1532-nm nanosecond pulses in quasi-phase matched germanosilicate optical fibers," Opt. Lett. 24, 208-210 (1999 1911-1913 (2006). 20. M. Buric, K. Chen, J. Falk, and S. Woodruff, "Enhanced spontaneous Raman scattering and gas composition analysis using a photonic crystal fiber," Appl. Opt. 47, 4255-4261 (2008).

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Hollow core photonic crystal fiber surface-enhanced Raman probe

Cited by 116 publications

References 21 publications

SERS-based detection in an optofluidic ring resonator platform

SERS-based detection in an optofluidic ring resonator platform

Highly efficient fluorescence sensing with hollow core photonic crystal fibers

Raman probes based on optically-poled double-clad fiber and coupler

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