Hollow Mesoporous Silica Nanoparticles Gated by Chitosan-Copper Sulfide Composites as Theranostic Agents for the Treatment of Breast Cancer

Niu, Shiwei; Zhang, Xintong; Williams, Gareth R.; Wu, Jianrong; Gao, Feng; Fu, Zi; Chen, Xia; Lü, Sheng; Zhu, Li‐Min

doi:10.1016/j.actbio.2021.03.024

Cited by 79 publications

(36 citation statements)

References 51 publications

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“…4D) . In this research, the role of CuS is introduced to prevent the sudden release of drugs into systemic circulations. 72 This targeted delivery was achieved by CuS NPs as gatekeepers attached to the surface of hollow silica. When exposed to near-infrared laser irradiation, the metal composites generated energy that causes the S–S bond to break and accelerates drug release.…”

Section: Metal Oxides Materials and Chalcogenides As Functional Compo...mentioning

confidence: 99%

“…CS is a material suitable for drug delivery systems: widely available, low-cost, biodegradable, biocompatible and pH sensitive. 73,74 Therefore, CS can be used to improve the biocompatibility and solubility of materials. Here, the anticancer drug was encapsulated on CS modified hollow structures with unreacted sulfhydryl groups bound to CuS via disulfide bonds.…”

Section: Metal Oxides Materials and Chalcogenides As Functional Compo...mentioning

confidence: 99%

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Utilization of metal or non-metal-based functional materials as efficient composites in cancer therapies

Chen

2022

RSC Adv.

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Section: Metal Oxides Materials and Chalcogenides As Functional Compo...mentioning

confidence: 99%

Section: Metal Oxides Materials and Chalcogenides As Functional Compo...mentioning

confidence: 99%

Utilization of metal or non-metal-based functional materials as efficient composites in cancer therapies

Chen

2022

RSC Adv.

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“…However, the effectiveness of traditional chemotherapy is limited by its poor selectivity, poor aqueous solubility, high systemic toxicity, and multidrug resistance [ 91 , 366 , 367 ]. MSNs have emerged as a potential drug delivery system that can both improve chemotherapy on its own [ 368 , 369 , 370 ] as well as in combination with other cancer therapies [ 90 , 371 , 372 ]. One of the major challenges of chemotherapy is the multidrug resistance (MDR) that is commonly attributed to the overexpression of the transmembrane efflux pump P-glycoprotein (P-gp) in cancer cells.…”

Section: Update On Msn Applications In Nanomedicinesmentioning

confidence: 99%

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

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“…The common trend is that the systems combining chemotherapy and PTT appear more efficient than protocols employing a single treatment. Niu et al described DDS combining PTT and chemotherapy approaches in a single formulation [159]. In particular, they employed hollow mesoporous silica nanoparticles selectively modified with chitosan conjugated with thioglycolic acid within the cavity.…”

Section: Exposure Limits Correction Factor Cmentioning

confidence: 99%

Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

Voronin

Abalymov

Svenskaya

et al. 2021

IJMS

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The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed.

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Hollow Mesoporous Silica Nanoparticles Gated by Chitosan-Copper Sulfide Composites as Theranostic Agents for the Treatment of Breast Cancer

Cited by 79 publications

References 51 publications

Utilization of metal or non-metal-based functional materials as efficient composites in cancer therapies

Utilization of metal or non-metal-based functional materials as efficient composites in cancer therapies

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

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