Hollow mesoporous SiO2–ZnO nanocapsules and effective in vitro delivery of anticancer drugs against different cancers with low doses of drugs

Facile cost-effective green synthesis of carbon dots: selective detection of biologically relevant metal ions and synergetic efficiency for treatment of cancer

“…The IC 50 for bare DOX was calculated to be ∼4.25 ± 0.12 µg ml −1 , whereas when it was encapsulated in CDs, the IC 50 was achieved to be ∼0.625 ± 0.1 µg ml −1 , which implied that a quite lower dose of CDs-DOX is enough to assassinate the cancer cells. In our earlier results, we used DOX with different nanocapsules for the treatment of MCF-7 cells and obtained a very high IC 50 (∼4.5 µg• ml−1) [66,67], whereas, DOX used with other nanoparticles reported [68,69] having very high IC 50 compared to the present finding. Therefore, these CDs have better efficacy in the treatment of breast cancer.…”

ZnO@SiO2 Nanocapsules: Efficient Fluorescence for Latent Fingerprint Detection

“…For the ZnO@SiO 2 nanocapsules, the absorption peaks at 1040 cm −1 are justified as the asymmetric stretching vibration of the Si−O−Si bond, [32] while the absorption peak at 796 cm −1 is caused by the Si−O−Si symmetric stretching vibration contribute [33] . Moreover, this band can be cross‐checked through 1634 cm −1 , which also is attributed to the scissor‐bending vibration of molecular water (−OH) [30] …”

“…Figure 4 shows the FTIR spectra of ZnO NPs and ZnO@SiO 2 nanocapsules with different ZnO NPs contents. All samples have an absorption peak at 464 cm −1 , which is ascribed to the vibration absorption of the Zn−O bond, [30] and which have all intense absorption peaks appeared at 3600–3000 cm −1 due to the O−H stretching of H‐bonding of free moisture [31] . For the ZnO@SiO 2 nanocapsules, the absorption peaks at 1040 cm −1 are justified as the asymmetric stretching vibration of the Si−O−Si bond, [32] while the absorption peak at 796 cm −1 is caused by the Si−O−Si symmetric stretching vibration contribute [33] .…”

“…[33] Moreover, this band can be cross-checked through 1634 cm À 1 , which also is attributed to the scissorbending vibration of molecular water (À OH). [30] XPS was further clarified the surface composition and elemental chemical status of Zn, Si, and O elements in the ZnO@SiO 2 -2 nanocapsules and ZnO NPs. The high-resolution Zn 2p spectrum shown in Figure 5a displays two peaks at 1022.1 eV (Zn 2p 3/2 ) and 1045.1 eV (Zn 2p 1/2 ), confirming the Zn 2 + exists in the ZnO@SiO 2 -2 nanocapsules.…”

“…The characteristic diffraction peaks in pure ZnO NPs are well indexed to ChemistrySelect hexagonal wurtzite structure ZnO (PDF#36-1451). After ZnO embeds into the SiO 2 matrix forming the ZnO@SiO 2 nanocapsules, the distinguished broadband at 22°connects to the presence of amorphous SiO 2 NPs, [30] and the other characteristic diffraction peaks are matching well with the characteristic peaks of the ZnO crystal phase, demonstrating that the SiO 2 matrix encapsulation does not affect the crystal structure of the core ZnO. Moreover, the intensity of the characteristic peaks of ZnO@SiO 2 nanocapsules gradually increases as the volume solution of ZnO NPs increases, implying that the ZnO NPs content of the hexagonal wurtzite crystal phase gradually increases.…”