Hollow polymer nanoparticles with S-nitrosothiols as scaffolds for nitric oxide release

Liu, Tuanwei; Zhang, Wei; Yang, Xinlin; Li, Chenxi

doi:10.1016/j.jcis.2015.08.011

Cited by 18 publications

(15 citation statements)

References 31 publications

(55 reference statements)

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“…Eudragit ® RL was used to prepare GSNO-loaded nanoparticles (GSNO-NP). Their release kinetics showed that C max was reached within 3 h and remained stable till 6 h. In another study, hollow S -nitrosothiol polymer nanoparticles as scaffolds for NO release were prepared were the release of NO was controlled by changing the polymer ratio and composition to reach a half-life reaching 225 min [45] , [46] . Thus, a viable approach to tuning SNOPC decomposition in vivo may be to conjugate the compounds with a suitable polymeric system.…”

Section: Resultsmentioning

confidence: 99%

In vivo pharmacological activity and biodistribution of S-nitrosophytochelatins after intravenous and intranasal administration in mice

et al. 2016

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S-nitrosophytochelatins (SNOPCs) are novel analogues of S-nitrosoglutathione (GSNO) with the advantage of carrying varying ratios of S-nitrosothiol (SNO) moieties per molecule. Our aim was to investigate the in vivo pharmacological potency and biodistribution of these new GSNO analogues after intravenous (i.v.) and intranasal (i.n.) administration in mice. SNOPCs with either two or six SNO groups and GSNO were synthesized and characterized for purity. Compounds were administered i.v. or i.n. at 1 μmol NO/kg body weight to CD-1 mice. Blood pressure was measured and biodistribution studies of total nitrate and nitrite species (NOx) and phytochelatins were performed after i.v. administration. At equivalent doses of NO, it was observed that SNOPC-6 generated a rapid and significantly greater reduction in blood pressure (∼60% reduction compared to saline) whereas GSNO and SNOPC-2 only achieved a 30–35% decrease. The reduction in blood pressure was transient and recovered to baseline levels within ∼2 min for all compounds. NOx species were transiently elevated (over 5 min) in the plasma, lung, heart and liver. Interestingly, a size-dependent phytochelatin accumulation was observed in several tissues including the heart, lungs, kidney, brain and liver. Biodistribution profiles of NOx were also obtained after i.n. administration, showing significant lung retention of NOx over 15 min with minor systemic increases observed from 5 to 15 min. In summary, this study has revealed interesting in vivo pharmacological properties of SNOPCs, with regard to their dramatic hypotensive effects and differing biodistribution patterns following two different routes of administration.

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Section: Resultsmentioning

confidence: 99%

In vivo pharmacological activity and biodistribution of S-nitrosophytochelatins after intravenous and intranasal administration in mice

et al. 2016

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“…Li and co-workers developed NO-releasing silica/polymer core shell particles using distillation precipitation polymerization. [53a, 54] Hollow polymeric particles were obtained by removing the silica core with a hydrofluoric acid solution. Nitric oxide storage was increased for N -diazeniumdiolate-modified hollow polymeric particles (5.5 μmol NO mg −1 ) relative to their non-hollow silica/polymer counterparts (3.6 μmol NO mg −1 ).…”

Section: Macromolecular Nitric Oxide Donorsmentioning

confidence: 99%

Nitric Oxide–Releasing Macromolecular Scaffolds for Antibacterial Applications

Yang

Feura

Ahonen

et al. 2018

Adv Healthcare Materials

160

124

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Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO-releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO-releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti-biofilm activity.

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“…In recent years, nanoparticle systems for intracellular NO delivery have attracted significant attention [12] to address problems associated with traditional NO donors such as low stability, burst release, and low intracellular delivery efficiency. [7,13] For examples, polymer, [14][15][16] silica, [17,18] and metal based [19] nanoparticles have been reported for NO delivery, either by encapsulation of commercial NO donors or post modification of NO donating moieties. Porous silica nanoparticles are reported to increase the stability of SNO compared to nonporous counterparts due to the so-called "cage effect".…”

Section: Introductionmentioning

confidence: 99%

Nanochemistry Modulates Intracellular Decomposition Routes of S‐Nitrosothiol Modified Silica‐Based Nanoparticles

Theivendran

2021

Small

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Cellular delivery of nitric oxide (NO) using NO donor moieties such as S‐nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH3) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, ≈10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH3 to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems.

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Hollow polymer nanoparticles with S-nitrosothiols as scaffolds for nitric oxide release

Cited by 18 publications

References 31 publications

In vivo pharmacological activity and biodistribution of S-nitrosophytochelatins after intravenous and intranasal administration in mice

In vivo pharmacological activity and biodistribution of S-nitrosophytochelatins after intravenous and intranasal administration in mice

Nitric Oxide–Releasing Macromolecular Scaffolds for Antibacterial Applications

Nanochemistry Modulates Intracellular Decomposition Routes of S‐Nitrosothiol Modified Silica‐Based Nanoparticles

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