Hollow Polypyrrole Nanospindles for Highly Effective Cancer Therapy

Abstract

Polypyrrole (PPy) hollow nanostructures continue to attract the interest researchers because of their good biocompatibility, high photothermal conversion efficiency, and excellent stability. The preparation of PPy hollow nanostructures by the hard templating method without complicated post-synthetic treatment and additional oxidizing agents remains a challenge. In this work, we report a facile and novel hard templating method to fabricate hollow PPy nanospindles in which MIL-88(Fe) serves as the template. Fe 3 + centers in MIL-88(Fe) could induce the polymerization of pyrrole to construct the shell, and MIL-88(Fe) would be decomposed by solvent water. This method did not require any extra oxidizing agents and post-synthetic treatment. Hollow PPy nanospindles exhibit excellent photothermal and drug loading ability, and the therapy effect of cancer was significant. This method provides a new hard templating approach for the synthesis of polymer hollow nanostructures.[a] Y.

Polypyrrole Nanomaterials: Structure, Preparation and Application

“…The application of hollow PPy nanomaterials in the field of photothermal therapy has also been reported [ 187 , 188 , 189 ]. Bhattarai et al [ 188 ] prepared PPy hollow fibers by polymerization of pyrrole on the sacrificial templates of electrospun polycaprolactone fibers.…”

Fully Programmable Collective Behavior of Light‐Powered Chemical Microrobotics: pH‐Dependent Motion Behavior Switch and Controlled Cancer Cell Destruction

“…In accordance with a modified version of the previously reported method, a standard etching procedure was started by mixing the MIL dispersion in ethanol (1 mL) with demineralized water (25 mL) and 1 mL of pyrrole monomer with the subsequent addition of 10 mM aqueous Methylene Blue (MB, 1 mL) 1 h after the start of the etching reaction. [ 60 ] To study the basic physical properties of the MIL/PPy composite, batches without MB were also fabricated. In all cases, the components (MIL, demineralized water, and pyrrole) were intensively mixed (1500 rpm; 15 min) prior to reaction.…”

“…Then the cells were washed with PBS and fixed in 4% formaldehyde for 20 min at 37 °C. The cells were then chemically dried using increasing concentrations of absolute ethanol (20,40,50,60,80,and 100%) and sputtered with a 5 nm layer of gold.…”