Hollow silver–gold alloy nanoparticles for enhanced photothermal/photodynamic synergetic therapy against bacterial infection and acceleration of wound healing

Lin, Shanshan; Chen, Hui; Jiang, Tongmeng; Wang, Rui; Yu, Fabiao

doi:10.1039/d3bm00567d

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…Recently, hollow silver–gold alloy nanoparticles immobilized with the photosensitising molecule Ce6 (Ag@Au-Ce6 NPs) integrated with PTT at 808 nm (800 mW/cm 2 for 5 min) and a 660 nm laser (200 mW/cm 2 for 5 min) were designed to accelerate wound healing in the context of infection by S. aureus (ATCC 25923) or E. coli (ATCC 25922). As a result of the heat effect provided by an NIR laser, Ag@Au-Ce6 NPs at 0.25 nM could effectively kill the free and colonized bacteria on the surface of the injured skin via the release of ROS, thereby promoting the vascularization of the skin epithelium and wound healing [ 101 ].…”

Section: Ptt Combined With Metal or Metal Oxide Nanoparticles As Anti...mentioning

confidence: 99%

Photothermal/Photoacoustic Therapy Combined with Metal-Based Nanomaterials for the Treatment of Microbial Infections

Duval

2023

Microorganisms

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The increased spread and persistence of bacterial drug-resistant phenotypes remains a public health concern and has contributed significantly to the challenge of combating antibiotic resistance. Nanotechnology is considered an encouraging strategy in the fight against antibiotic-resistant bacterial infections; this new strategy should improve therapeutic efficacy and minimize side effects. Evidence has shown that various nanomaterials with antibacterial performance, such as metal-based nanoparticles (i.e., silver, gold, copper, and zinc oxide) have intrinsic antibacterial properties. These antibacterial agents, such as those made of metal oxides, carbon nanomaterials, and polymers, have been used not only to improve antibacterial efficacy but also to reduce bacterial drug resistance due to their interaction with bacteria and their photophysical properties. These nanostructures have been used as effective agents for photothermal therapy (PTT) and photodynamic therapy (PDT) to kill bacteria locally by heating or the controlled production of reactive oxygen species. Additionally, PTT or PDT therapies have also been combined with photoacoustic (PA) imaging to simultaneously improve treatment efficacy, safety, and accuracy. In this present review, we present, on the one hand, a summary of research highlighting the use of PTT-sensitive metallic nanomaterials for the treatment of bacterial and fungal infections, and, on the other hand, an overview of studies showing the PA-mediated theranostic functionality of metal-based nanomaterials.

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Section: Ptt Combined With Metal or Metal Oxide Nanoparticles As Anti...mentioning

confidence: 99%

Photothermal/Photoacoustic Therapy Combined with Metal-Based Nanomaterials for the Treatment of Microbial Infections

Duval

2023

Microorganisms

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“…At present, multidrug-resistant (MDR) bacterial infections remain a serious public health threat and may have lasting effects on the normal functioning of affected organs. − The common clinical approach to eliminating bacterial infections relies heavily on antibiotic therapy. − However, the therapeutic efficacy is inevitably undermined, and the bacterial resistance has increased with the irrational and indiscriminate use of antibiotics. , In addition, most pathogenic bacteria do not typically exist in the human environment as individual organisms or in planktonic states. Instead, they tend to form populations known as biofilms, making it difficult for small-molecule antimicrobial agents to penetrate effectively and ultimately leading to insensitivity to antimicrobial agents. − Therefore, the development of a new antimicrobial nanomaterial targeting biofilms formed by drug-resistant bacteria is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Quaternized Silk Fibroin Nanocarriers Loaded with Chlorin e6 for Photodynamic Elimination of Drug-Resistant Bacteria and Biofilms

Xu,

Cui,

Wang

et al. 2024

ACS Appl. Nano Mater.

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The increasing prevalence of multidrug-resistant (MDR) bacteria primarily due to the emergence of drug-resistant biofilms that have rendered current antimicrobial agents ineffective poses a significant concern in public health. Therefore, innovative antimicrobial agents need to be urgently developed. This study aimed to design a photodynamic antimicrobial nanocomposite (Ce6/HSF) based on chitosan quaternary ammonium salt (HTCC)-functionalized silk fibroin (SF) loaded with chlorin e6 (Ce6) for eliminating drug-resistant biofilms and bacteria. The prepared Ce6/HSF had low toxicity, good biocompatibility, and excellent ability to generate single-linear-state oxygen. In addition, Ce6/HSF can enter multidrug-resistant bacteria by electrostatic adsorption due to its small size and cationic nature. Furthermore, it effectively promoted wound healing in mice infected with MDR Staphylococcus aureus.

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“…Silver nanoparticle-conjugated graphene quantum dots have been demonstrated for the enhancement of bactericidal efficacy through blue light-activated photothermal therapy [ 18 ]. Hollow silver–gold alloy nanoparticles immobilized with a photosensitizer have been applied to combine photothermal therapy and photodynamic therapy to effectively eliminate bacteria and enhance wound healing by inducing mild hyperthermia and controlled singlet oxygen generation upon near-infrared laser activation [ 19 ]. Numerous studies have been undertaken to validate the photothermal therapy of plasmonic silver-based nanomaterials, renowned for their potent photothermal effects [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Au@Ag Core–Shell Nanoisland Film for Photothermal Inactivation and Surface-Enhanced Raman Scattering Detection of Bacteria

Husain,

Mutalik,

Yougbaré

et al. 2024

Nanomaterials

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Plasmonic metal nanomaterials have been extensively investigated for their utilizations in biomedical sensing and treatment. In this study, plasmonic Au@Ag core–shell nanoisland films (Au@AgNIFs) were successfully grown onto a glass substrate using a seed-mediated growth procedure. The nanostructure of the Au@AgNIFs was confirmed through scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and atomic force microscopy (AFM). The UV-Vis spectra of the Au@AgNIFs exhibited a broad absorption in the visible range from 300 to 800 nm because of the surface plasmon absorption. Under simulated sunlight exposure, the temperature of optimal Au@AgNIF was increased to be 66.9 °C to meet the requirement for photothermal bacterial eradication. Furthermore, the Au@AgNIFs demonstrated a consistent photothermal effect during the cyclic on/off exposure to light. For photothermal therapy, the Au@AgNIFs revealed superior efficiency in the photothermal eradication of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). With their unique nanoisland nanostructure, the Au@AgNIFs exhibited excellent growth efficiency of bacteria in comparison with that of the bare glass substrate. The Au@AgNIFs were also validated as a surface-enhanced Raman scattering (SERS) substrate to amplify the Raman signals of E. coli and S. aureus. By integrating photothermal therapy and SERS detection, the Au@AgNIFs were revealed to be a potential platform for bacterial theranostics.

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Hollow silver–gold alloy nanoparticles for enhanced photothermal/photodynamic synergetic therapy against bacterial infection and acceleration of wound healing

Abstract: Bacterial infection seriously restricts the wound healing process due to the severe inflammations and delayed wound healing. Unfortunately, the over or improper use of antibiotics leads to the advent of...

Cited by 12 publications

References 46 publications

Photothermal/Photoacoustic Therapy Combined with Metal-Based Nanomaterials for the Treatment of Microbial Infections

Photothermal/Photoacoustic Therapy Combined with Metal-Based Nanomaterials for the Treatment of Microbial Infections

Quaternized Silk Fibroin Nanocarriers Loaded with Chlorin e6 for Photodynamic Elimination of Drug-Resistant Bacteria and Biofilms

Plasmonic Au@Ag Core–Shell Nanoisland Film for Photothermal Inactivation and Surface-Enhanced Raman Scattering Detection of Bacteria

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