Holocaust exposure and late-life cognitive performance in men with coronary heart disease

Weinstein, Galit; Lutski, Miri; Boker, Lital Keinan; Goldbourt, Uri; Tanné, David

doi:10.1016/j.jpsychires.2020.12.044

Cited by 4 publications

(6 citation statements)

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“…The negative impact on the well-being of Holocaust survivors is consistent with the survivor-specific effect hypothesis [ 154 ], marked by loss and lack [ 143 , 163 , 167 ]. This impact manifests itself through cognitive deterioration [ 184 ], worse quality of life, worse health perception [ 174 ], and mood changes [ 143 , 173 ]. However, these survivors also show well-being, despite the Holocaust, through proactive and cognitive adaptation [ 160 ] and socio-emotional selectivity [ 165 ].…”

Section: Resultsmentioning

confidence: 99%

“…Shmotkin et al [ 180 ] found that women were more likely to be Inflated (high happiness and high suffering) whereas men were more likely to be Deflated (low happiness and low suffering); it was more probable that Holocaust survivors would be Deflated and Unhappy in the negative though not in the positive moments. Weinstein et al [ 184 ] found that concentration camp/ghetto survivors had poorer global cognitive performance and attention compared to individuals who were not exposed to Holocaust conditions. Isaacowitz et al [ 165 ] discovered that socioemotional selectivity related to positive mental health in all groups besides the Holocaust survivors, who usually exhibit high negative affect, and social networks of other survivors also undergoing distress.…”

Section: Discussionmentioning

confidence: 99%

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Dark tourism, the holocaust, and well-being: A systematic review

Magano

Brea

Leite

2023

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dark tourism, the holocaust, and well-being: A systematic review

Magano

Brea

Leite

2023

Heliyon

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“…The Holocaust's impact on aging cognition remains unclear, with some studies suggesting no increased risk for cognitive impairment in older HS, while others report poorer cognitive function and a higher prevalence of dementia than the general population 6,11–13 …”

Section: Introductionmentioning

confidence: 99%

Preoperative cognitive impairment and postoperative delirium among Holocaust survivors who achieved longevity

Weiss,

Zarour,

Kiselevich

et al. 2024

J American Geriatrics Society

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BackgroundHolocaust survivors (HS) experience higher rates of physiological and psychological morbidities, increasing their vulnerability to perioperative complications. Limited information exists regarding their perioperative neurocognitive disorders. This study aimed to assess the rates of preoperative cognitive impairment, postoperative delirium, and other complications among HS aged 75+ undergoing elective surgery.MethodsThis is a single‐center retrospective cohort study that analyzed prospectively collected data. All surgical patients born before 1945 who underwent elective noncardiac surgery at a tertiary hospital in Israel during 2020–2021 were included. The HS group was identified through the hospital's information system. Preoperative cognitive impairment was assessed using the Mini‐Cog test. Postoperative delirium was defined as a combined outcome, which included a positive 4A's‐Test (4AT) result during the postanesthesia care unit stay up to the second postoperative day, a positive 3‐Minute Diagnostic Confusion Assessment Method (3D‐CAM) test administered by the geriatric team, and identification through the medical records using the Chart‐based Delirium Identification Instrument (CHART‐DEL). We used multivariable regression to assess the risk factors for postoperative delirium.ResultsOut of 1332 eligible patients, 422 (32%) were HS, while the others served as controls. Both groups had a similar rate of preoperative cognitive impairment (24%, p = 0.89) and postoperative delirium (16%, p = 0.95). HS exhibited a higher risk of the composite adverse events (24% vs. 20%, p = 0.05, aOR [95% CI] 1.3 [1.0–1.7]), driven mainly by falls during hospitalization (4% vs. 2%, p = 0.03, aOR 2.1 [1.1–4.1]). HS patients were more likely to be childless (33% vs. 11%, p = 0.001) and had higher rates of chronic antidepressant and benzodiazepine use.ConclusionsHS achieving longevity do not face increased risks of preoperative cognitive impairment and postoperative delirium. However, special care is still warranted due to their elevated rate of other complications during hospitalization.

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“…Commonly, interventional therapy is required for patients with severe conditions. And it is imperative to utilize anti-platelet aggregation drugs after interventional therapy to avoid myocardial infarction [4][5][6]. Of which, lowmolecular-weight heparin (LMWH) is often used clinically to treat patients with coronary heart disease in interventional therapy via the manner of subcutaneous injection, and is characterized by fast decomposition and easy absorption.…”

Section: Introductionmentioning

confidence: 99%

Mitigating effect of clopidogrel and systematic management on adverse events after interventional therapy for coronary heart disease

Shao¹,

Chen²

2022

Trop. J. Pharm Res

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Purpose: To investigate the efficacy of clopidogrel combined with systemic management care in the prevention of adverse events in patients with coronary heart disease after interventional therapy.Methods: 100 patients undergoing interventional therapy after coronary heart disease admitted to Jinan Third People’s Hospital from April 2018 to April 2020 were assigned at a ratio of 1:1 either into control (low-molecular-weight heparin (LMWH) injection) or study groups randomly (clopidogrel plus system management care). Thrombin time, prothrombin time, fibrinogen, incidence of adverse events, NIHSS score and QLI score were determined for the two groups.Results: There thrombin time, prothrombin time and fibrinogen in the two groups were similar (p >0.05). The study group showed a significantly lower incidence of adverse events than the control group (p < 0.05). The treatment administered to the study group resulted in a higher QLI (quality of life) scores than those in the control group (p < 0.05). Remarkably lower National Institutes of Health Stroke Scale (NIHSS) score was reported in the study group versus control group (p < 0.05).Conclusion: Clopidogrel plus systemic management care might be a preferable therapeutic strategy for patients with coronary heart disease undergoing interventional therapy. It reduces the incidence of adverse events, significantly improves the quality of life of patients, and enhances neurological function. Thus, this therapeutic strategy has significant promise in the management of coronary heart disease.

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Holocaust exposure and late-life cognitive performance in men with coronary heart disease

Cited by 4 publications

References 36 publications

Dark tourism, the holocaust, and well-being: A systematic review

Dark tourism, the holocaust, and well-being: A systematic review

Preoperative cognitive impairment and postoperative delirium among Holocaust survivors who achieved longevity

Mitigating effect of clopidogrel and systematic management on adverse events after interventional therapy for coronary heart disease

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