The upper catchment of the Claro river is located within the Transitional Southern Volcanic Zone in the Maule Region of Chile (35.5°S), at the foothills of Manantial Pelado volcano, a Pleistocene stratovolcano whose morphology suggests the occurrence of important glacial processes in the area. The observed glacial landforms can be sequenced and associated with episodes of volcanic activity. Different units of volcanic and glacial origin were identified based on field observations, detailed mapping, and digital elevation model and satellite image analysis. The contact relations between them made it possible to discern four events that can be linked to Marine Isotope Stages 8, 6, 4‐2, and to the Neoglacial. We propose seven stages in the geomorphological evolution from the late Pleistocene to the late Holocene, where there is coexistence between volcanic and glacial episodes, such as the emplacement of the Manantial Pelado volcano overlying the Abanico and Cola de Zorro formations; a subsequent debris avalanche; the enlargement of the Del Indio valley during the Penultimate Glaciation; the construction of Cerro Redondo (a minor eruptive center at the head of Del Indio valley); ongoing fluvial incision; and Neoglacial advances. The relative chronology proposed in this work contributes to clarifying the Pleistocene–Holocene geomorphological history in this catchment and to further understand the interplay between volcanic and glacial processes in the central Chilean Andes during the Quaternary.