The beginning of plant cultivation is one of the most important cultural
transitions in human history
1
–
4
. Based on
molecular markers showing the genetic similarities between domesticated plants
and wild relatives, south-western Amazonia has been proposed as one of the early
centres of plant domestication
4
–
6
. However,
the nature of the early human occupation and the history of plant cultivation in
south-western Amazonia are still little understood. Here, we document the
cultivation of
Cucurbita
at ca. 10,250 cal yr BP,
Manihot
at ca. 10,350 cal yr BP and
Zea
mays
at ca. 6,850 cal yr BP in the Llanos de Moxos. We show that,
starting ca. 10,850 cal yr BP, pre-Columbians created an anthropic landscape
made of approximately 4,700 artificial forest islands within a treeless
seasonally flooded savannah. Our results confirm the Llanos de Moxos as a
hotspot for early plant cultivation and demonstrate that ever since their
arrival, humans have caused a profound alteration of Amazonian landscapes, with
lasting repercussions for habitat heterogeneity and species conservation.