Radiocarbon dating is one of the most useful and widely used chronometric techniques available for archaeologists and other paleo-scientists. Although generally used for answering specific research questions, radiocarbon dates from archaeological sites have become increasingly used to reconstruct population change at meso and macro temporal and spatial scales, and Bayesian modeling of locally and regionally available dates is facilitating interrogating the synchronicity, correlation, and interaction among various socioecological variables. Because the results of these meta-analyses largely depend on the available data, comprehensive compilations of radiocarbon dates and their associated information are critically important. Moreover, a thorough assessment of these compilations can reveal research spatiotemporal foci, trends, and biases, which should be considered when meta-analyses are attempted. In this review, based on the recently compiled Bolivian Radiocarbon Database, I provide a general assessment of the temporal, geographic, and thematic interests that have driven archaeological and paleoecological research in Bolivia over the last seven decades. Along with a detailed review of research in three broad geographical regions (Andean highlands, inter-Andean valleys, and tropical lowlands), I encourage researchers interested in meta-analysis to critically consider biases in data compilations by means of increased engagement with local experts and interdisciplinary collaboration.