Holographic glucose sensors

Kabilan, Satyamoorthy; Marshall, Alexander J.; Sartain, Felicity K.; Lee, Mei‐Ching; Hussain, Abid; Yang, Xiaoping; Blyth, Jeff; Karangu, N.; James, K.; Zeng, Jimmy; Smith, Dawn A.; Domschke, Angelika; Lowe, Christopher R.

doi:10.1016/j.bios.2004.07.005

Cited by 158 publications

(121 citation statements)

References 27 publications

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“…Previously in acrylamide-based hydrogel sensors, 20 mol% 3-APBA was found to be the optimum in hydrogel-based glucose sensors. [27] Supporting Information Figure S8 shows that light attenuation did not change between precursors (AM:PEGDA:3-APBA, 77/3/20 mol% in DMSO) before and after filtering (0.22 μm), indicating that 3-APBA completely dissolves in DMSO. The attenuation decreased 4.6% after polymerization in DMSO.…”

Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

“…, (3-acrylamidopropyl)trimethylammonium) with PBA derivatives. [35] Alternatively, PBA derivatives such as 2-acrylamido-5-fluorophenylboronic acid, [8] 2-(acrylamido)phenylboronate, [36] 4-vinylphenylboronic acid (4-VPBA), [37] or their copolymerized combinations [38] can be used to improve the selectivity of the hydrogel fiber sensors to glucose. Electron-withdrawing substituents may increase the sensor response by decreasing the p K a of PBA.…”

Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

“…[1b, 5] Optical sensors offer advantages over electrochemical assays since they can be constructed to be label-free, provide real-time continuous monitoring for long periods of time, are immune to electromagnetic interference, and can be calibrated internally. [6] One of the promising approaches for optical glucose sensors is to covalently incorporate glucose-sensitive chelating agents such as phenylboronic acid (PBA) derivatives [7] into matrixes such as or micro- and nanostructures including holographic thin films, [8] crystalline colloidal arrays, [9] plasmonic nanoantennas, [10] Fabry-Perot cavities, [11] fluorescent dyes, [12] and quantum dots (QDs). [13] Optical monitoring systems have also been developed in the form of solid-state optodes that report on the glucose concentration via refractive index (RI) changes.…”

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confidence: 99%

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Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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Optical fibers are widely used in biomedical applications for sensing, imaging, and therapies. Unlike existing solid-state optical fibers, soft polymer and hydrogel fibers offer physical and chemical properties well suited for functionalization with biomolecules and long-term implantation in the body. Here, hydrogel optical fibers are fabricated with glucose-sensitive moieties and the swelling-induced sensing is demonstrated. The core of the fiber is made of poly(acrylamide-co-poly(ethylene glycol) diacrylate) (p(AM-co-PEGDA)) hydrogel functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis diols of glucose molecules lowers the apparent pKa of the hydrogel network and increases the concentration of the boronate anions that enhances the Donnan osmotic pressure to swell and change the physical size of the hydrogel optical fiber. This mechanism is reversible through ester group dynamic covalent binding of the phenylboronic acid with glucose molecules. Dynamic changes in the effective RI of the hydrogel optical fiber are measured through light propagation loss. The sensor sensitivity to glucose concentration is 1.2 mmol L−1 over a physiological range of 1–12 mmol L−1. The biocompatible hydrogel optical fibers may be subcutaneously implanted for continuous monitoring of interstitial glucose concentrations.

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Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

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confidence: 99%

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Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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“…Changes in swelling can also be sensed by attaching the gel to a pressure sensor. Sensors can also be based on fluorescence changes in sensitive molecules in the gel [191], on volume changes of gel particles changing the diffraction angle from a colloidal crystal [192,193], by color changes in a gel hologram [194,195] and other responses [196].…”

Section: Gel Sensorsmentioning

confidence: 99%

Polymer Gel Actuators: Fundamentals

Calvert

2009

Biomedical Applications of Electroactive Polymer Actuators

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One view of materials development is to search for what materials correspond to empty spaces on a hypothetical multi-dimensional map of the properties of available materials. Following a biomimetic philosophy, for instance, it can be seen that tough ceramics and moldable short fiber composites with high moduli are possible but absent from the list of available synthetic materials. Likewise artificial muscle is missing, where the properties are defined as a developed stress of over 300 kPa, a linear contraction of 25 % and a response time of below one second. Currently dielectric elastomers come closest but have disadvantages [1,2].The actin-myosin muscle system provides the performance target for electroactive polymer actuators [3,4]. The process is driven chemically by the energy change from hydrolysis of the polyphosphate bond as ATP (adenosine triphosphate) binds to myosin and is converted to ADP (adenosine diphosphate) and phosphate. A simple chemical analogy suggests that muscle-like gels should be feasible but it is now clear that the task is much harder than it seems.Early work on gel actuation by Katchalsky-Katzir demonstrated that engines could be built using the chemical energy in diluting a lithium bromide solution to drive contraction and expansion of a collagen belt [5]. In essence, the collagen expands to take up the salt solution or contract to exclude the water. This change is both a molecular conformation change and a volume change. Other chemically driven gels, for instance polyacrylic acid fibers [6] which respond to a pH change, also rely on a solubility change giving rise to a volume change.

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“…One of the most commonly researched derivatives of boronic acids for binding glucose is phenylboronic acid (PBA) or its derivatives, with the pK a value of PBA being 8.9. Lowe et al constructed a holographic sensor for monitoring glucose using a PBA derivative, namely 4-vinylphenylboronic acid, copolymerized with acrylamide using N,N′-methylenebisacrylamide as crosslinker [232]. Stable hydrogel films with pendant PBA groups were obtained.…”

Section: Glucose-sensitive Gels-mentioning

confidence: 99%

Smart polymeric gels: Redefining the limits of biomedical devices

Chaterji

Kwon

Park

2007

Progress in Polymer Science

559

364

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This review describes recent progresses in the development and applications of smart polymeric gels, especially in the context of biomedical devices. The review has been organized into three separate sections: defining the basis of smart properties in polymeric gels; describing representative stimuli to which these gels respond; and illustrating a sample application area, namely, microfluidics. One of the major limitations in the use of hydrogels in stimuli-responsive applications is the diffusion rate limited transduction of signals. This can be obviated by engineering interconnected pores in the polymer structure to form capillary networks in the matrix and by downscaling the size of hydrogels to significantly decrease diffusion paths. Reducing the lag time in the induction of smart responses can be highly useful in biomedical devices, such as sensors and actuators. This review also describes molecular imprinting techniques to fabricate hydrogels for specific molecular recognition of target analytes. Additionally, it describes the significant advances in bottom-up nanofabrication strategies, involving supramolecular chemistry. Learning to assemble supramolecular structures from nature has led to the rapid prototyping of functional supramolecular devices. In essence, the barriers in the current performance potential of biomedical devices can be lowered or removed by the rapid convergence of interdisciplinary technologies.

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Holographic glucose sensors

Cited by 158 publications

References 27 publications

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

Polymer Gel Actuators: Fundamentals

Smart polymeric gels: Redefining the limits of biomedical devices

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