Holohemispheric Invasive Aspergillus Granulomatous Cerebritis of the Brain

Promising effects of corticosteroid treatment in combination with antifungal agents in a patient with Aspergillus meningitis

“…One of the patients (a known case of wegener granulomatosis) was cured with AMB (29 days) + ICZ (410 days), another individual (suffering from laryngeal cancer) receiving AMB (25 days) + ICZ (13 days) died, and the last one (a case of systemic lupus erythematosus and end‐stage renal disease) was cured by receiving liposomal AMB (44 days) + VCZ and ITZ (380 days) 10 . Taking into consideration that outcomes of monotherapy vs. combination therapy could be an important point of comparison in previous reports of neuroaspergillosis, Karthic et al reported an expired case that was treated with VCZ, 11 Haroon and colleagues mentioned another expired case who received AMB, 12 but the overall results of combination therapy were more promising; Gruter et al reported a neuroaspergillosis patient (who also had thyroid cancer) receiving VCZ+ AMB+ ISZ who was cured 5 . Leroy et al 13 and Turki et al 14 both reported cured cases of neuroaspergillosis treated with VCZ + liposomal AMB, and of 5 cases described in Tattevin and colleagues' study, 3 were cured by combination therapy 10 …”