“…In a large series of 4,157,224 births, the same authors observed 370 infants with suspected holoprosencephaly (0,009%) stressing that isolated HPE was homogeneous among the 11 sampled countries, increasing from 0.5/10,000 births to 1/10,000 births between 1967 and 2000% [6]. The early embryonic occurrence may be even higher with prevalence of 1:250 in embryos [7] but may not be detected due to most fetuses aborting in early gestation [2]. In our small series of 4000 MRI explorations in children of different ages (from newborns to 15 years old) only three cases harboring HPE were diagnosed, accounting for almost 0.05%.…”