Holtzman Inkblot Technique

Holtzman, Wayne H.

doi:10.1007/978-3-662-39575-2_6

Cited by 70 publications

(109 citation statements)

References 33 publications

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“…[11] In the past it was used an emetic agent, but is now considered too toxic for ingestion. [12] Copper sulfate (insoluble in DMSO) was dissolved in H 2 O, and the copper sulfate data is presented relative to a H 2 O control. Copper sulfate inhibits Hs PBGS with comparable potency to Nitrofurazone and exhibits an IC 50 of 2.2 ± 0.1 μM (Table 1), and yields conversion to greater than 50% hexamer in the native PAGE assay at the highest concentration tested (Supplemental Fig.…”

Section: Resultsmentioning

confidence: 99%

Diverse Clinical Compounds Alter the Quaternary Structure and Inhibit the Activity of an Essential Enzyme

2011

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An in vitro evaluation of the Johns Hopkins Clinical Compound Library demonstrates that certain drugs can alter the quaternary structure of an essential human protein. Human porphobilinogen synthase (HsPBGS) is an essential enzyme involved in heme biosynthesis; it exists as an equilibrium of high activity octamers, low activity hexamers, and alternate dimer configurations that dictate the stoichiometry and architecture of further assembly. Reduced HsPBGS activity is implicated in toxicities associated with lead poisoning and ALAD porphyria, the latter of which involves hexamer-favoring HsPBGS variants. A medium-throughput native PAGE mobility shift screen, coupled with evaluation of hits as HsPBGS inhibitors, revealed twelve drugs that stabilize the HsPBGS hexamer and inhibit HsPBGS activity in vitro. A detailed characterization of these effects is presented. Drug inhibition of HsPBGS in vivo by inducing hexamer formation would constitute an unprecedented mechanism for side effects. We suggest that small molecule perturbation of quaternary structure equilibria be considered as a general mechanism for drug action and side effects.

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Section: Resultsmentioning

confidence: 99%

Diverse Clinical Compounds Alter the Quaternary Structure and Inhibit the Activity of an Essential Enzyme

2011

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“…We used the ‘Union‐2’ compilation by Amanullah et al (2010) as our SNe data set, obtained from the web site http://supernova.lbl.gov/Union. This compilation of 557 SNe includes data from Hamuy et al (1996), Riess et al (1999, 2007), Astier et al (2006), Jha et al (2006), Wood‐Vasey et al (2007), Holtzman et al (2008), Hicken et al (2009) and Kessler et al (2009).…”

Section: Determination Of the Cosmic Expansion Historymentioning

confidence: 99%

The WiggleZ Dark Energy Survey: measuring the cosmic expansion history using the Alcock-Paczynski test and distant supernovae

Blake¹,

Glazebrook²,

Davis³

et al. 2011

Monthly Notices of the Royal Astronomical Society

143

128

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Astronomical observations suggest that today's Universe is dominated by a dark energy of unknown physical origin. One of the most notable results obtained from many models is that dark energy should cause the expansion of the Universe to accelerate: but the expansion rate as a function of time has proved very difficult to measure directly. We present a new determination of the cosmic expansion history by combining distant supernovae observations with a geometrical analysis of large-scale galaxy clustering within the WiggleZ Dark Energy Survey, using the Alcock-Paczynski test to measure the distortion of standard spheres. Our result constitutes a robust and non-parametric measurement of the Hubble expansion rate as a function of time, which we measure with 10-15 per cent precision in four bins within the redshift range 0.1 < z < 0.9. We demonstrate, in a manner insensitive to the assumed cosmological model, that the cosmic expansion is accelerating. Furthermore, we find that this expansion history is consistent with a cosmological-constant dark energy.

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“…This sample has increased the number of well‐measured Type Ia SN of the previous Union (Kowalski et al 2008) at high redshifts by the combination of different data sets. The Union sample has been extended with six Type Ia SN presented in Amanullah et al (2010), the SN from Amanullah et al (2008) and the low‐ and intermediate‐ z data from Hicken et al (2009) and Holtzman et al (2008) respectively.…”

Section: Observational Datamentioning

confidence: 99%

Supernova and baryon acoustic oscillation constraints on (new) polynomial dark energy parametrizations: current results and forecasts

Sendra¹,

Lazkoz²

2012

Monthly Notices of the Royal Astronomical Society

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In this work we introduce two new polynomial parametrizations of dark energy and explore their correlation properties. The parameters to fit are the equation-of-state values at z = 0 and z = 0.5, which have naturally low correlation and have already been shown to improve the popular Chevallier-Polarski-Linder (CPL) parametrization. We test our models with low-redshift astronomical probes: type Ia supernovae and baryon acoustic oscillations (BAO), in the form of both current and synthetic data. Specifically, we present simulations of measurements of the radial and transversal BAO scales similar to those expected in a BAO high-precision spectroscopic redshift survey such as EUCLID. According to the Bayesian deviance information criterion (DIC), which penalizes large errors and correlations, we show that our models perform better than the CPL reparametrization proposed by Wang (in terms of z = 0 and z = 0.5). This is due to the combination of lower correlation and smaller relative errors. The same holds for a frequentist perspective: the figure-of-merit is larger for our parametrizations.

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Holtzman Inkblot Technique

Cited by 70 publications

References 33 publications

Diverse Clinical Compounds Alter the Quaternary Structure and Inhibit the Activity of an Essential Enzyme

Diverse Clinical Compounds Alter the Quaternary Structure and Inhibit the Activity of an Essential Enzyme

The WiggleZ Dark Energy Survey: measuring the cosmic expansion history using the Alcock-Paczynski test and distant supernovae

Supernova and baryon acoustic oscillation constraints on (new) polynomial dark energy parametrizations: current results and forecasts

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