HOMA-Estimated Insulin Resistance Is an Independent Predictor of Cardiovascular Disease in Type 2 Diabetic Subjects

Bonora, Enzo; Formentini, G.; Calcaterra, Francesco; Lombardi, Simonetta; Marini, F; Zenari, Luciano; Saggiani, F.; Poli, Maurizio; Perbellini, S.; Raffaelli, Andrea; Cacciatori, V.; Santi, Lorenza; Targher, Giovanni; Bonadonna, Riccardo C.; Muggeo, Michele

doi:10.2337/diacare.25.7.1135

Cited by 534 publications

(352 citation statements)

References 54 publications

(47 reference statements)

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“…Insulin and PTH were measured by automated chemiluminescence method 0.25(OH)D was measured by HPLC method. HOMAIR was calculated from fasting insulin and fasting glucose [28].…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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Vitamin D is recognized to serve a wide range of biological functions. The presence of vitamin D receptors on different tissues explains it's diversity of actions. Reduced levels of vitamin D is associated with insulin resistance and increased diabetes risk. The study included 50 normal healthy individuals and 49 type 2 diabetes subjects. Fasting blood glucose, total cholesterol, triglycerides, HDLc, fasting insulin, parathyroid hormone, calcium, albumin and Homeostasis model for assessment of insulin resistance (HOMAIR) were measured in all the study participants. Type 2 diabetes subjects were divided into group 1 with 25 hydroxy vitamin D (25(OH)D) B20 ng/ml and group 2 with 25(OH)D [20 ng/ml. By the results of this study, the mean 25(OH)D level was low (20.09 ng/ml) in type 2 diabetes compared to controls (23.89 ng/ml) and the p value was 0.02. The estimated insulin resistance by HOMAIR was more in group 1 than in group 2 of diabetes with p value of 0.037. The Pearson's correlation-coefficient was negative for 25(OH)D and insulin in type 2 diabetes (r = -0.294), 25(OH)D was negatively correlated with HOMAIR in total subjects. Type 2 diabetes subjects had reduced levels of vitamin D than normal individuals. The insulin resistance was more in vitamin D deficiency state. Hence vitamin D has a role in glucose metabolism, deficiency can result in insulin resistance and diabetes.

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“…Insulin and PTH were measured by automated chemiluminescence method 0.25(OH)D was measured by HPLC method. HOMAIR was calculated from fasting insulin and fasting glucose [28].…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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“…It has been shown that the HOMA-IR index was able to rank individuals according to insulin resistance in a similar way as the euglycemic hyperinsulinemic clamp. 16 …”

Section: Identification Of the Metabolic Syndromementioning

confidence: 99%

Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome

et al. 2006

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Objective: To investigate whether leukocyte count, fibrinogen, von Willebrand factor (vWF) and plasminogen activator inhibitor-1 activity (PAI-1) are increased in subjects with the metabolic syndrome as defined by the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) and the World Health Organisation (WHO). Design: Cross-sectional study. Subjects: A total of 520 overweight and obese subjects: 379 women and 141 men, visiting the weight management clinic of a University Hospital. Subjects and measurements: Waist circumference, triglycerides, HDL cholesterol, blood pressure and fasting glucose were determined, and the presence or absence of the metabolic syndrome according to the NCEP-ATPIII criteria was assessed. In 349 subjects, data on the waist-to-hip ratio (WHR) and albumin excretion rate were available and the WHO criteria were applied. Insulin resistance was defined using the HOMA-IR index. Results: Subjects with the metabolic syndrome according to the NCEP-ATPIII criteria had significantly higher levels of leukocyte count (Po0.001) and PAI-1 (Po0.001), while no significant differences were found for fibrinogen or vWF (P40.05). Using the WHO criteria, similar results were found except for vWF, where higher levels were found in subjects with the metabolic syndrome. When subjects were classified according to the number of components of the metabolic syndrome, levels of leukocyte count, vWF and PAI-1 activity were significantly different (Po0.05). In logistic regression analysis PAI-1, gender and leukocyte count were independent determinants of the metabolic syndrome (Po0.001). Conclusion: Evidence for being a true component of the metabolic syndrome is strong for PAI-1, less for leukocyte count and weak for vWF and fibrinogen.

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“…Plasma insulin concentrations were measured by radioimmunoassay. Insulin resistance was estimated by calculation of homeostasis model assessment-insulin resistance (HOMA-IR) (Bonora et al, 2002); low HOMA-IR concentrations indicate high, whereas high HOMA-IR concentrations indicate low insulin sensitivity (insulin resistance).…”

Section: Measurementsmentioning

confidence: 99%

Association of Prostate Specific Antigen Concentration with Lifestyle Characteristics in Korean Men

Woo

Park²,

Kwon³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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We investigated the relationships between demographics, lifestyle characteristics, and serum total prostate specific antigen (PSA) concentration and examined the population-based distribution of total PSA by age among 2,246 Korean men with a median age of 45 years. We obtained data about demographic and lifestyle characteristics based on self-reporting using a questionnaire. We also performed physical examinations, anthropometric measurements, and biochemical measurements. The PSA concentration increased with age and there was a significant difference in total PSA concentration between the age groups of 21-60 years and >60 years. Age >60 years, height ≥1.8 m, a low frequency of alcohol consumption, and taking nutritional supplements showed a significantly increased odds ratio for increased PSA when 3.0 ng/ mL was chosen as the PSA cut-off level. Smoking status, BMI, percent body fat, diabetes mellitus, fatty liver, herbal medicine use, vitamin use, and diet were not significantly associated with total PSA regardless of the cut-off level. When interpreting a single PSA test, height, alcohol consumption, and nutritional supplement use should be considered, in addition to age.

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HOMA-Estimated Insulin Resistance Is an Independent Predictor of Cardiovascular Disease in Type 2 Diabetic Subjects

Cited by 534 publications

References 54 publications

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome

Association of Prostate Specific Antigen Concentration with Lifestyle Characteristics in Korean Men

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