Cognitive behaviour therapy (CBT) and selective serotonin reuptake inhibitors have both been established as effective interventions for paediatric obsessive-compulsive disorder (OCD), with CBT being the recommended first-line treatment in most cases. While the majority of young people respond well to these treatments, a significant proportion remain symptomatic. Although the research on treatment-resistant OCD remains limited, increasing empirical attention is being paid to predictors of treatment outcome in young people with OCD, and efforts are being made to identify the factors that hinder recovery. This article outlines potential barriers in treatment and highlights strategies for optimising outcome, with particular focus on cognitive behavioural techniques.
Key Practitioner Message:• Treatment-resistance in obsessive-compulsive disorder (OCD) should initiate a reformulation of the case, which could include a review of diagnosis, comorbidity, and environmental factors • Failure to respond to cognitive behaviour therapy (CBT) may reflect a characteristic of the treatment rather than the individual • Motivation enhancement strategies, intensive CBT or home-based CBT may be effective interventions in treatment-resistant cases • Young people who have not responded to serotonergic medication may benefit from augmentation with a lowdose of an atypical antipsychotic medication