Home-based exercise improves functional performance and quality of life in women with diastolic heart failure

Gary, Rebecca; Sueta, Carla A.; Dougherty, Molly C.; Rosenberg, Beth; Cheek, Dennis J.; Preisser, John S.; Neelon, Virginia J.; McMurray, Robert G.

doi:10.1016/j.hrtlng.2004.01.004

Cited by 159 publications

(140 citation statements)

References 47 publications

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“…Overall Jehn et al 50 Radke et al 24 Alahdab et al 18 Alahdab et al 18 Rostagno et al 13 Rostagno et al 45 Ingle et al 26 Jehn et al 36 Ingle et al 26 Deuschle et al 52 Rostagno et al 46 Bagur et al 48 Zugck et al 21 Pepera et al 32 Goode et al 18 Deuschle et al 52 Faggiano et al 47 Leszek et al 35 Rostagno et al 13 Goode et al 7 Zugck et al 21 Ingle et al 26 Ingle et al 26 Rostagno et al 45 Tay et al 49 Jankowska et al 29 Bagur et al 48 Ates et al 30 Rostagno et al 46 Gary et al 25 Jehn et al 36 Karavidaset al 28 Souza et al 53 Jehn et al 50 Bosnak Güçlü et al 27 Alahdab et al 18 Forman et al 20 Zaidi et al Goscinska-Bis et al 37 Alahdab et al 18 Forman et al 20 Keast et al 31 Vrtovec et al 51 Rostagno et al 45 Souza et al 53 Tay et al 49 Jaski et al 34 Zugck et al …”

Section: Discussionmentioning

confidence: 99%

Correlation of the New York Heart Association Classification and the 6‐Minute Walk Distance: A Systematic Review

Yap

Lim

Gao

et al. 2015

Clinical Cardiology

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Background: Functional status assessment is the cornerstone of heart failure management and trials. The New York Heart Association (NYHA) classification and 6-minute walk distance (6MWD) are commonly used tools; however, the correlation between them is not well understood. Hypothesis: We hypothesised that the relationship between the NYHA classification and 6MWD might vary across studies. Methods: A systematic literature search was performed to identify all studies reporting both NYHA class and 6MWD. Two reviewers independently assessed study eligibility and extracted data. Thirty-seven studies involving 5678 patients were included. Results: There was significant heterogeneity across studies in 6MWD within all NYHA classes: I (n = 16, Q = 934.2; P < 0.001), II (n = 25, Q = 1658.3; P < 0.001), III (n = 30, Q = 1020.1; P < 0.001), and IV (n = 6, Q = 335.5; P < 0.001). There was no significant difference in average 6MWD between NYHA I and II (420 m vs 393 m; P = 0.416). There was a significant difference in average 6MWD between NYHA II and III (393 m vs 321 m; P = 0.014) and III and IV (321 m vs 224 m; P = 0

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Section: Discussionmentioning

confidence: 99%

Correlation of the New York Heart Association Classification and the 6‐Minute Walk Distance: A Systematic Review

Yap

Lim

Gao

et al. 2015

Clinical Cardiology

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“…Therefore, the importance of aggressive management of such comorbidities -both cardiac and non-cardiac -cannot be overemphasized [134,135]. There is some evidence that exercise training is effective in decreasing symptoms and improving quality of life [136]. The severity of diastolic dysfunction can serve as a useful guide to treatment.…”

Section: Treatmentmentioning

confidence: 99%

Heart Failure with Preserved Ejection Fraction

Čulić

2017

N Engl J Med

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Heart failure with preserved ejection fraction (HFpEF) has recently emerged as a major cause of cardiovascular morbidity and mortality. Contrary to initial beliefs, HFpEF is now known to be as common as heart failure with reduced ejection fraction (HFrEF) and carries an unacceptably high mortality rate. With a prevalence that has been steadily rising over the past two decades, it is very likely that HFpEF will represent the dominant heart failure phenotype over the coming few years. The scarcity of trials in this semi-discrete form of heart failure and lack of unified enrolment criteria in the studies conducted to date might have contributed to the current absence of specific therapies. Understanding the epidemiological, pathophysiological and molecular differences (and similarities) between these two forms of heart failure is cornerstone to the development of targeted therapies. Carefully designed studies that adhere to unified diagnostic criteria with the recruitment of appropriate controls and adoption of practical end-points are urgently needed to help identify effective treatment strategies.

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“…Exercise training is beneficial in patients with heart failure (40) and improves exercise tolerance (27,37), quality of life (16,43), and cardiac structure (4,46). Training-induced benefits in heart failure have been attributed predominantly to adaptations in the peripheral circulation and skeletal muscles (52,53), whereas improvements in ventricular function have largely been ascribed to reverse remodeling secondary to afterload reduction and improved endothelial function (21,22).…”

Section: Discussionmentioning

confidence: 99%

Rescue of heart lipoprotein lipase-knockout mice confirms a role for triglyceride in optimal heart metabolism and function

Khan

Yan

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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IJ.Rescue of heart lipoprotein lipase-knockout mice confirms a role for triglyceride in optimal heart metabolism and function. Am J Physiol Endocrinol Metab 305: E1339 -E1347, 2013. First published October 1, 2013; doi:10.1152/ajpendo.00349.2013.-Hearts utilize fatty acids as a primary source of energy. The sources of those lipids include free fatty acids and lipoprotein triglycerides. Deletion of the primary triglyceride-hydrolyzing enzyme lipoprotein lipase (LPL) leads to cardiac dysfunction. Whether heart LPL-knockout (hLPL0) mice are compromised due a deficiency in energetic substrates is unknown. To test whether alternative sources of energy will prevent cardiac dysfunction in hLPL0 mice, two different models were used to supply nonlipid energy. 1) hLPL0 mice were crossed with mice transgenically expressing GLUT1 in cardiomyocytes to increase glucose uptake into the heart; this cross-corrected cardiac dysfunction, reduced cardiac hypertrophy, and increased myocardial ATP. 2) Mice were randomly assigned to a sedentary or training group (swimming) at 3 mo of age, which leads to increased skeletal muscle production of lactate. hLPL0 mice had greater expression of the lactate transporter monocarboxylate transporter-1 (MCT-1) and increased cardiac lactate uptake. Compared with hearts from sedentary hLPL0 mice, hearts from trained hLPL0 mice had adaptive hypertrophy and improved cardiac function. We conclude that defective energy intake and not the reduced uptake of fat-soluble vitamins or cholesterol is responsible for cardiac dysfunction in hLPL0 mice. In addition, our studies suggest that adaptations in cardiac metabolism contribute to the beneficial effects of exercise on the myocardium of patients with heart failure. triglyceride; heart failure; glucose; lactate; energetics; glucose transporters IN THE HEALTHY ADULT HUMAN HEART, most of the energy required for normal cellular processes is derived from the uptake and oxidation of fatty acids (FAs), with the remainder being contributed by glucose, lactate, and amino acids (36). FAs are delivered to the heart either as free fatty acids (FFAs) conjugated to albumin or via lipoprotein lipase (LPL)-mediated hydrolysis of lipoproteins, with subsequent uptake by FAT/CD36, other FA transporters, and nonreceptor mediated pathways (5).Cardiomyocyte deletion of LPL (hLPL0) leading to reduced triglyceride (TG) lipolysis increased cardiac glucose uptake and reduced expression of several peroxisomal proliferatoractivated receptor (PPAR) regulated genes (1). hLPL0 hearts developed reduced ejection fraction (2) and were unable to compensate when subjected to increased afterload due to aortic coarctation or hypertension (56). These data suggest that TG is an important source of lipid for cardiac energy.In heart failure, traditional cardiac substrate usage of FAs is perturbed, and as a result the heart shifts away from FA oxidation to glucose utilization. These changes in heart energy use have been studied experimentally in isolated hearts using buffers containing FFAs (35). W...

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Home-based exercise improves functional performance and quality of life in women with diastolic heart failure

Cited by 159 publications

References 47 publications

Correlation of the New York Heart Association Classification and the 6‐Minute Walk Distance: A Systematic Review

Correlation of the New York Heart Association Classification and the 6‐Minute Walk Distance: A Systematic Review

Heart Failure with Preserved Ejection Fraction

Rescue of heart lipoprotein lipase-knockout mice confirms a role for triglyceride in optimal heart metabolism and function

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